Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

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Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection

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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

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Revealing the History of Sheep Domestication Using Retrovirus Integrations

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The sheep genome illuminates biology of the rumen and lipid metabolism

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Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits

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Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

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Life history trade-offs at a single locus maintain sexually selected genetic variation

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Convergent genomic signatures of domestication in sheep and goats

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A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheepPreprint

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Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition

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Polar Overdominance at the Ovine callipyge Locus

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Genome‐wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population

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Identification of the Single Base Change Causing the Callipyge Muscle Hypertrophy Phenotype, the Only Known Example of Polar Overdominance in MammalsPreprint

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Molecular and pharmacological characterization of dominant black coat color in sheep

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Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system

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Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers.

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The Genome Landscape of Tibetan Sheep Reveals Adaptive Introgression from Argali and the History of Early Human Settlements on the Qinghai–Tibetan Plateau

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Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight

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Genetic basis of ruminant headgear and rapid antler regeneration

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Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds

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Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci

Lv, F., Cao, Y.-H., Liu, G., Luo, L.-Y., Lu, R., Liu, M., Li, W., Zhou, P., Wang, X., Shen, M., et al. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab353 · Cited by 185

Revealing the selection history of adaptive loci using genome-wide scans for selection: an example from domestic sheep

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A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries)

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Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization

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Compelling evidence that a single nucleotide substitution inTYRP1is responsible for coat-colour polymorphism in a free-living population of Soay sheep

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Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep

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Genome-Wide Association Study for Wool Production Traits in a Chinese Merino Sheep Population

Wang, Z., Zhang, H., Yang, H., Wang, S., Rong, E., Pei, W., Li, H., & Wang, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107101 · Cited by 127

Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds

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A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypesPreprint

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Wool Keratin-Associated Protein Genes in Sheep—A Review

Gong, H., Zhou, H., Forrest, R., Li, S., Wang, J., Dyer, J., Luo, Y., & Hickford, J. (2016) · Genes · doi:10.3390/genes7060024 · Cited by 124

A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis aries)

Boman, I. A., Klemetsdal, G., Blichfeldt, T., Nafstad, O., & Våge, D. I. (2009) · Animal Genetics · doi:10.1111/j.1365-2052.2009.01855.x · Cited by 117

Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition

Li, B., Qiao, L., An, L., Wang, W., Liu, J., Ren, Y., Pan, Y., Jing, J., & Liu, W. (2018) · BMC Genomics · doi:10.1186/s12864-018-4747-1 · Cited by 116

A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model

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Genomic selection signatures in sheep from the Western Pyrenees

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A 1.8‐kb insertion in the 3′‐UTR of RXFP2 is associated with polledness in sheep

Wiedemar, N., & Drögemüller, C. (2015) · Animal Genetics · doi:10.1111/age.12309 · Cited by 111

Xanthophyll Pigmentation in Sheep Fat

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Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

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A Localized Negative Genetic Correlation Constrains Microevolution of Coat Color in Wild Sheep

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Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep

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Genome-wide association reveals QTL for growth, bone and in vivo carcass traits as assessed by computed tomography in Scottish Blackface lambs

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Using comparative genomics to reorder the human genome sequence into a virtual sheep genome

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Lipoprotein Lipase Activity and mRNA Are Up-Regulated by Refeeding in Adipose Tissue and Cardiac Muscle of Sheep

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Genome-Wide Variation, Candidate Regions and Genes Associated With Fat Deposition and Tail Morphology in Ethiopian Indigenous Sheep

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Paternal Origins and Migratory Episodes of Domestic Sheep

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Runs of homozygosity and signatures of selection: a comparison among eight local Swiss sheep breeds

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Deep transcriptome analysis using RNA-Seq suggests novel insights into molecular aspects of fat-tail metabolism in sheep

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The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep

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Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes

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An improved ovine reference genome assembly to facilitate in-depth functional annotation of the sheep genome

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Mapping the Horns (Ho) Locus in Sheep: A Further Locus Controlling Horn Development in Domestic Animals

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Transcriptome profile analysis of adipose tissues from fat and short-tailed sheep

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Signatures of selection identify loci associated with fat tail in sheep1

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Genetic Parameters of Udder Traits, Somatic Cell Score, and Milk Yield in Latxa Sheep

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Major genes and QTL influencing wool production and quality: a review

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Genome-Wide Identification of the Mutation Underlying Fleece Variation and Discriminating Ancestral Hairy Species from Modern Woolly Sheep

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Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles

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Skin transcriptome profiles associated with coat color in sheep

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Detailed phenotyping identifies genes with pleiotropic effects on body composition

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Transcriptome Profile at Different Physiological Stages Reveals Potential Mode for Curly Fleece in Chinese Tan Sheep

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Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9

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Development of a Linkage Map and Mapping of Phenotypic Polymorphisms in a Free-Living Population of Soay Sheep (Ovis aries)

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Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays

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CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep

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Impact of two myostatin (MSTN) mutations on weight gain and lamb carcass classification in Norwegian White Sheep (Ovis aries)

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A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep.

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Genome‐wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries)

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Underlying functional genomics of fat deposition in adipose tissue

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Genome-wide detection of copy number variation in Chinese indigenous sheep using an ovine high-density 600 K SNP array

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Evidence of linkage between high‐glycine‐tyrosine keratin gene loci and wool fibre diameter in a Merino half‐sib family

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Genomic Scan for Selection Signature Reveals Fat Deposition in Chinese Indigenous Sheep with Extreme Tail Types

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Horn type and horn length genes map to the same chromosomal region in Soay sheep

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Genome-wide mRNA-seq profiling reveals predominant down-regulation of lipid metabolic processes in adipose tissues of Small Tail Han than Dorset sheep

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Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep

Zhang, R., Li, Y., Jia, K., Xu, X., Li, Y., Zhao, Y., Zhang, X., Zhang, J., Liu, G., Deng, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2622-x · Cited by 69

A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries)

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Genomic analysis of worldwide sheep breeds reveals PDGFD as a major target of fat-tail selection in sheep

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Multiple-trait QTL mapping and genomic prediction for wool traits in sheep

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RNA-Seq based genetic variant discovery provides new insights into controlling fat deposition in the tail of sheep

Bakhtiarizadeh, M. R., & Alamouti, A. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-70527-8 · Cited by 64

Mapping and Characterization of the Dominant Black Colour Locus in Sheep

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Genome‐wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep

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Differences in the expression of the ASIP gene are involved in the recessive black coat colour pattern in sheep: evidence from the rare Xalda sheep breed

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Comparative Transcriptome Profiling of mRNA and lncRNA Related to Tail Adipose Tissues of Sheep

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Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype

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Genetic (co)variances between wrinkle score and absence of breech strike in mulesed and unmulesed Merino sheep, using a threshold model

Scholtz, A. J., Cloete, S. W. P., van Wyk, J. B., Misztal, I., Toit, E. D., & van der Linde, T. C. D. K. (2010) · Animal Production Science · doi:10.1071/an09033 · Cited by 29

Physiological and genetic characteristics of black‐boned sheep (Ovis aries)

Deng, W., Yang, S., Huo, Y. Q., Gou, X., Shi, X. W., & Mao, H. (2006) · Animal Genetics · doi:10.1111/j.1365-2052.2006.01530.x · Cited by 29

Effects of vertebral number variations on carcass traits and genotyping of Vertnin candidate gene in Kazakh sheep

Zhang, Z., Sun, Y., Du, W., He, S., Liu, M., & Tian, C. (2017) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.16.0959 · Cited by 29

Analysis of polymorphisms in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes and association with coat colours in two Pramenka sheep types

Fontanesi, L., Rustempasic, A., Brka, M., & Russo, V. C. (2012) · Small Ruminant Research · doi:10.1016/j.smallrumres.2012.02.008 · Cited by 28

Polyceraty (multi‐horns) in Damara sheep maps to ovine chromosome 2

Greyvenstein, O., Reich, C. M., van Marle-Köster, E., Riley, D. G., & Hayes, B. J. (2016) · Animal Genetics · doi:10.1111/age.12411 · Cited by 28

GLIS1, a potential candidate gene affect fat deposition in sheep tail

Luo, R., Zhang, X., Wang, L., Zhang, L., Li, G., & Zheng, Z. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06468-w · Cited by 28

Natural adaptation and human selection of northeast African sheep genomes

Ahbara, A., Musa, H. H., Robert, C., Abebe, A., Al-Jumaili, A. S., Kebede, A., Latairish, S., Agoub, M. O., Clark, E. L., Hanotte, O., et al. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110448 · Cited by 28

ORIGINAL ARTICLE: mRNA abundance of adiponectin and its receptors, leptin and visfatin and of G-protein coupled receptor 41 in five different fat depots from sheep

Lemor, A., Mielenz, M., Altmann, M., von Borell, E., & Sauerwein, H. (2010) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2010.00987.x · Cited by 27

Hornedness and polledness in sheep. II. The inheritance of horns in Merino ewes

Dolling, C. (1960) · Australian Journal of Agricultural Research · doi:10.1071/ar9600618 · Cited by 27

Dag score is negatively correlated with breech bareness score of sheep

Scobie, D. R., O’Connell, D., Morris, C. A., & Hickey, S. M. (2008) · Australian Journal of Experimental Agriculture · doi:10.1071/ea07397 · Cited by 27

Mapping the four‐horned locus and testing the polled locus in three Chinese sheep breeds

He, X., Zhou, Z., Pu, Y., Chen, X., Ma, Y., & Jiang, L. (2016) · Animal Genetics · doi:10.1111/age.12464 · Cited by 27

Association Between BMP2 Functional Polymorphisms and Sheep Tail Type

Lu, Z., Liu, J., Han, J., & Yang, B. (2020) · Animals · doi:10.3390/ani10040739 · Cited by 27

Regulatory Roles of SREBF1 and SREBF2 in Lipid Metabolism and Deposition in Two Chinese Representative Fat-Tailed Sheep Breeds

Liang, C., Qiao, L., Han, Y., Liu, J., Zhang, J., & Liu, W. (2020) · Animals · doi:10.3390/ani10081317 · Cited by 27

Transcriptome reveals key microRNAs involved in fat deposition between different tail sheep breeds

Fei, X., Jin, M., Wang, Y., Li, T., Lu, Z., Yuan, Z., Wang, H., Lü, J., Quan, K., Di, R., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264804 · Cited by 27

Identification of SNPs within the sheep PROP1 gene and their effects on wool traits

Zeng, X.-C., Chen, H.-Y., Jia, B., Zhao, Z., Hui, W., Wang, Z., & Du, Y. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0416-4 · Cited by 26

Multi-vertebrae variation potentially contribute to carcass length and weight of Kazakh sheep

Li, C., Zhang, X., Cao, Y., Wei, J., You, S., Jiang, Y., Cai, K., Wumaier, W., Guo, D., Qi, J., et al. (2017) · Small Ruminant Research · doi:10.1016/j.smallrumres.2017.02.021 · Cited by 26

Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep

Liu, Y., Zhang, J., Xu, Q., Kang, X., Wang, K., Wu, K., & Fang, M. (2018) · BMC Genomics · doi:10.1186/s12864-018-4736-4 · Cited by 26

Bioinformatics analysis of evolutionary characteristics and biochemical structure of FGF5 Gene in sheep

Zhang, R., Wu, H., & Lian, Z. (2019) · Gene · doi:10.1016/j.gene.2019.03.040 · Cited by 26

Verification and Analysis of Sheep Tail Type-Associated PDGF-D Gene Polymorphisms

Li, Q., Lu, Z., Jin, M., Fei, X., Quan, K., Liu, Y., Ma, L., Chu, M., Wang, H., & Wei, C. (2020) · Animals · doi:10.3390/ani10010089 · Cited by 26

Ovine ELOVL5 and FASN genes polymorphisms and their correlations with sheep tail fat deposition

Zhao, L., Li, F., Liu, T., Yuan, L., Zhang, X., Zhang, D., Li, X., Zhang, Y., Zhao, Y., Song, Q., et al. (2021) · Gene · doi:10.1016/j.gene.2021.145954 · Cited by 26

Colour inheritance in sheep

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Production of Brown/Yellow Patches in the SLC7A11 Transgenic Sheep via Testicular Injection of Transgene

He, X., Li, H., Zhou, Z., Zhao, Z., & Li, W. (2012) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2012.04.005 · Cited by 25

Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3.

Smith, L. B., Dally, M., Sainz, R., Rodrigue, K., & Oberbauer, A. (2006) · Journal of Animal Science · doi:10.2527/jas.2006-255 · Cited by 25

The Agouti gene: a positional candidate for recessive self-colour pigmentation in Australian Merino sheep

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Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter

Bai, L., Wang, J., Zhou, H., Gong, H., Tao, J., & Hickford, J. G. H. (2019) · Animals · doi:10.3390/ani9040142 · Cited by 25

Discovery of SNPs in RXFP2 related to horn types in sheep

Wang, X., Zhou, G., Li, Q., Zhao, D., & Chen, Y. (2013) · Small Ruminant Research · doi:10.1016/j.smallrumres.2013.10.022 · Cited by 24

THE ANCON OR OTTER SHEEP

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Application of genomic data to assist a community-based breeding program: A preliminary study of coat color genetics in Morada Nova sheep

Muniz, M. M. M., Caetano, A. R., Mcmanus, C. M., Cavalcanti, L. C. G., Façanha, D. A. E., Leite, J. H. G. M., Facó, O., & Paiva, S. R. (2016) · Livestock Science · doi:10.1016/j.livsci.2016.06.006 · Cited by 24

Whole-body adipose tissue multi-omic analyses in sheep reveal molecular mechanisms underlying local adaptation to extreme environments

Xu, Y., Wang, B., Jing, J.-N., Ma, R., Luo, Y.-H., Li, X., Yan, Z., Liu, Y.-J., Gao, L., Ren, Y., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04523-9 · Cited by 83

Heritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs

Wang, W., Zhang, Y., Zhang, X., Li, C., Yuan, L., Zhang, D., Zhao, Y., Li, X., Cheng, J., Lin, C., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01642-7 · Cited by 73

Meat of Sheep: Insights into Mutton Evaluation, Nutritive Value, Influential Factors, and Interventions

Ding, W., Yanan, L., Xu, B., Chen, P., Li, J., Jian, F., Yu, G., & Huang, S. (2024) · Agriculture · doi:10.3390/agriculture14071060 · Cited by 59

Phenotype transition from wild mouflon to domestic sheep

Mereu, P., Pirastru, M., Sanna, D., Bassu, G., Naitana, S., & Leoni, G. G. (2024) · Genetics Selection Evolution · doi:10.1186/s12711-023-00871-6 · Cited by 35

Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness

Zhang, W., Jin, M., Li, T., Lu, Z., Wang, H., Yuan, Z., & Wei, C. (2023) · Animals · doi:10.3390/ani13182944 · Cited by 30

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Xu, S., & Li, M.-H. (2017) · Frontiers of Agricultural Science and Engineering · doi:10.15302/j-fase-2017151 · Cited by 37

Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

Li, X., Yang, J. H., Shen, M., Xie, X.-L., Liu, G., Xu, Y., Lv, F., Yang, H., Yang, Y., Liu, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16485-1 · Cited by 374

From markers to mechanisms: a comprehensive review of major genes and quantitative trait loci shaping the modern sheep (Ovis aries)

Ghaderi‐Zefrehei, M., Esfahani, E. N., Pozveh, H. A., Hashemi, M., Dolati, P., Zakizadeh, S., Montazeri‐Najafabadi, M., Dolatabady, M. M., Imumorin, I. G., & Banabazi, M. H. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1865980

Additional file 1 of Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

Kalds, P., Zhou, S., Gao, Y., Cai, B., Huang, S., Chen, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.21076767

Trends towards revealing the genetic architecture of sheep tail patterning: Promising genes and investigatory pathways

Kalds, P., Luo, Q., Sun, K., Zhou, S., Chen, Y., & Wang, X. (2021) · Animal Genetics · doi:10.1111/age.13133 · Cited by 51