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Cited by 59Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsDiet and metabolism studies

Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome?

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Shishehgar, Farnaz, Mirmiran, Parvin, Rahmati, Maryam, Tohidi, Maryam, Ramezani Tehrani, Fahimeh·2019·BMC Endocrine Disorders
DOI 10.1186/s12902-019-0420-1PMC PMC6720418
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Abstract

BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the effect of this diet on the clinical and hormonal features of PCOS women. METHODS: This interventional study was carried out at the Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Of 108 women invited for the purpose of the present study, 62 participants (PCOS = 28, non-PCOS = 34) followed a 24-week energy restricted LGI diet. Anthropometric, biochemical, hormonal and clinical measurements were documented at baseline, 12 weeks and 24 weeks with intervention. RESULTS: The percentages of weight loss achieved by both the PCOS and non-PCOS groups did not differ significantly (PCOS: -8.04% vs. non-PCOS: -8.09%). No significant difference in decrease of homeostatic model assessment of insulin resistance (HOMA-IR) was observed between the two groups (PCOS = - 0.83 ± 0.33, non PCOS = - 0.79 ± 0.28, P = 0.83). In PCOS women, significant reduction in total testosterone (- 0.91 ± 0.33 nmol/L, P = 0.006), FAI (- 4.47 ± 1.1, P < 0.001) and increase in SHBG (38.98 ± 11.02 nmol/L, P < 0.001) were observed. Menstrual irregularity was improved in 80% of women with PCOS and a significant decrease (32.1%) in occurrence of acne was reported. CONCLUSIONS: This diet has equally beneficial effects on anthropometric and metabolic characteristics of overweight women with and without PCOS. TRIAL REGISTRATION: This study is registered in the Iranian Randomized Clinical Trials Registry (IRCT, code: IRCT2016092129909N1 ).

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  • Some studies lacked a control group, used different measures of cardiometabolic risk, and had an inability to determine what is driving the relationship of improvement in cardiometabolic risk factors.

    “include the lack of a control group [97,98], different measures of cardiometabolic risk [96], and the inability to determine what is driving the relationship of the improvement in cardiometabolic risk factors”

    From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [96]

    The citing sentence attributes a lack of a control group to the studies cited at that point. This paper says the opposite in Discussion, “Strengths and limitations” (page unavailable): it identifies having a control group as a study strength. That section lists other measurement limitations, but does not describe the study as lacking controls. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Shishehgar, F., Mirmiran, P., Rahmati, M., Tohidi, M., & Ramezani Tehrani, F.
Affiliations
  • Islamic Azad University, Tehran (IR)
  • Research Institute for Endocrine Sciences (IR)
  • Tehran University of Medical Sciences (IR)
ORCID
Venue
BMC Endocrine Disorders
Publisher
Springer Science and Business Media LLC
Published
2019-09-02
Volume
19
Issue
1
Pages
93-93
ISSN
1472-6823 (ISSN-L)
DOI
10.1186/s12902-019-0420-1
PMC
PMC6720418
OpenAlex
W2971934744
Cited by
59
References
10
Citations by year
2026: 7 · 2025: 3 · 2024: 8 · 2023: 15 · 2022: 10 · 2021: 11 · 2020: 5
FWCI
6.22
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Endocrine Disorders (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
  • Core Research for Evolutional Science and Technology
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
polycystic ovary syndrome, low glycemic index diet, caloric restriction, weight loss, insulin resistance, testosterone, sex hormone-binding globulin, free androgen index, menstrual irregularity, acne, overweight women, dietary intervention
MeSH terms
Adolescent, Adult, Diet, Reducing, Female, Follow-Up Studies, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Prognosis, Weight Loss, Body Mass Index, Case-Control Studies, Caloric Restriction, Glycemic Index, Overweight, Young Adult

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