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Cited by 82Ovarian function and disordersObesity, Physical Activity, DietHypothalamic control of reproductive hormones

Effect of weight loss on menstrual function in adolescents with polycystic ovary syndrome

Ornstein, Rollyn M., Copperman, Nancy M., Jacobson, Marc S.·2011·Journal of Pediatric and Adolescent Gynecology
DOI 10.1016/j.jpag.2011.01.002
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Abstract

Study objective To compare the effects of a hypocaloric low-fat diet with those of a very low carbohydrate diet on body mass index (BMI), waist circumference (WC), and menstrual function in overweight adolescent females with polycystic ovary syndrome (PCOS).Design Randomized pilot trial of two diets in a prospective, 12-week study.Setting A hospital-based, academic adolescent medicine division.Participants 24 females, age 12-22 years (mean 15.8 ± 2.2), with PCOS and a BMI above the 85(th) percentile for age (mean 35.7 ± 6.0 kg/m(2)).Interventions Nutrition counseling was given biweekly, and dietary compliance, menstrual history, and weight were recorded. WC was measured at the beginning and end of the study.Main outcome measures Changes in weight, BMI, WC, and improvement in menstrual function over the course of the study period.Results 16 participants completed the study. 12 completers menstruated during the study period, 8 with regularity. The number of periods over 3 months increased from 0.6 ± 0.6 pre-treatment to 1.6 ± 1.3 post-treatment (P = 0.003). Overall, weight loss averaged 6.5% (P < 0.0001) and the WC decreased by an average of 5.7 ± 7.7 cm (P = 0.01). Those who lost weight were 3.4 times more likely to have improved menstrual function (P = 0.001). There were no statistically significant differences between the two groups.Conclusions Weight loss is feasible in adolescents with PCOS and results in significant improvements in BMI, WC, and menstrual function. Weight management may be preferable as first-line treatment in adolescents, because it targets both the menstrual dysfunction and risk factors for long-term morbidity associated with PCOS.

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  • A low-carbohydrate diet (20 to 40 g/d) and a hypocaloric diet (<40 g of fat per day) during 12 weeks improved weight and menstrual irregularities with no difference between the diets.

    “A low-carbohydrate diet (20 to 40 g/d) and a hypocaloric diet (<40 g of fat per day) during 12 weeks improved weight and menstrual irregularities with no difference between the diets.”

    From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [166]

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Authors
Ornstein, R. M., Copperman, N. M., & Jacobson, M. S.
Affiliations
  • Pennsylvania State University (US)
  • Northwell Health (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
Ornstein, Rollyn M.
ORCID
Ornstein, Rollyn M.
Venue
Journal of Pediatric and Adolescent Gynecology
Publisher
Elsevier BV
Published
2011-06
Volume
24
Issue
3
Pages
161-165
ISSN
  • 0932-8610 (ISSN-L)
  • 1083-3188
DOI
10.1016/j.jpag.2011.01.002
OpenAlex
W2112093850
Cited by
82
References
43
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 12 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
5.36
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pediatric and Adolescent Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
polycystic ovary syndrome, adolescents, weight loss, menstrual function, very low carbohydrate diet, overweight, body mass index, waist circumference, nutrition counseling, weight management
MeSH terms
Adolescent, Child, Diet, Reducing, Female, Humans, Menstruation, Pilot Projects, Polycystic Ovary Syndrome, Prospective Studies, Weight Loss, Body Mass Index, Diet, Fat-Restricted, Caloric Restriction, Diet, Carbohydrate-Restricted, Waist Circumference, Young Adult

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