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Cited by 21Cervical Cancer and HPV ResearchReproductive tract infections researchWomen's cancer prevention and management

A population based study on human papillomavirus infection and associated risk factors among women of the remote South Andaman Island, India

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Parvez, Rehnuma, Vijayachari, Paluru, Thiruvengadam, Kannan, Roy, Avijit, Saha, Mrinmoy Kumar, Ramasamy, Jawahar, Vins, Alwin, Biswas, Lipika +3 more·2024·BMC Women's Health
DOI 10.1186/s12905-024-02967-7PMC PMC10893608
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Abstract

Background: Human papillomavirus (HPV) is associated with cervical cancer and cervical dysplasia worldwide. Data on HPV prevalence in a region is important because it serves as a predictor of the likelihood of the population in that particular region acquiring cervical cancer. Moreover, with the availability of effective vaccines, the public health system must be aware of the preponderance of HPV to implement the vaccine. The present study was designed to understand the prevalence of HPV and associated factors among the women of South Andaman Island. Methods: A cross-sectional study was conducted among married women of reproductive age (18–59 years) from South Andaman District from 2018 to 2022. Cervical scrapes were collected from participants after obtaining informed written consent for HPV molecular testing (HPV DNA) such as PCR assay. Demographic data was collected using a standard questionnaire and statistical analyses were performed to determine the associated factors. Results: The study showed prevalence of HPV as 5.9%(95% CI: 3.9–7.9) and prevalence of HR-HPV16 was 4.1% (95% CI 2.6 – 5.5) and HR-HPV18 prevalence was 1.8(95% CI: 0.6–3). The independent factors associated the HPV positivity were age above 55 years, menopause, post-menopausal bleeding, blood-stained vaginal discharge and loss of weight. Age was associated with all HPV infections among the South Andaman women. Conclusions: HPV 16 was reported as the predominant high risk HPV type circulating among women of South Andaman. Cervical cancer and precancerous lesions were significantly associated with HPV positivity and High risk HPV 16. Based on the knowledge of the risk factors associated with HPV, implementation of stronger public health awareness and prophylactic HPV vaccination is crucial among the women of this remote island.

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Authors
Parvez, R., Vijayachari, P., Thiruvengadam, K., Roy, A., Saha, M. K., Ramasamy, J., Vins, A., Biswas, L., Vaz, A., Kaur, H., & Nagarajan, M.
Affiliations
  • Indian Council of Medical Research (IN)
  • Regional Medical Research Centre (IN)
  • Govind Ballabh Pant Hospital (IN)
  • Vinayaka Missions University (IN)
Corresponding author
Parvez, Rehnuma
ORCID
Venue
BMC Women's Health
Publisher
Springer Science and Business Media LLC
Published
2024-02-23
Volume
24
Issue
1
Pages
139-139
ISSN
1472-6874 (ISSN-L)
DOI
10.1186/s12905-024-02967-7
PMC
PMC10893608
OpenAlex
W4392101696
Cited by
21
References
39
Citations by year
2026: 9 · 2025: 10 · 2024: 2
FWCI
6.41
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Women s Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Indian Council of Medical Research (File no. Tribal/117/2020-ECD-II (2020-5180))
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords
human papillomavirus, HPV prevalence, high-risk HPV, HPV16, HPV 18, risk factors, cervical cancer, cervical intraepithelial neoplasia, menopause, postmenopausal bleeding, South Andaman, remote island populations, HPV vaccination
MeSH terms
Adolescent, Adult, Uterine Cervical Neoplasms, Cross-Sectional Studies, Female, Humans, India, Middle Aged, Risk Factors, Prevalence, Papillomaviridae, Papillomavirus Infections, Human papillomavirus 16, Papillomavirus Vaccines, Young Adult

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