Using the Medical Research Council framework for development and evaluation of complex interventions in a low resource setting to develop a theory-based treatment support intervention delivered via SMS text message to improve blood pressure control
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BACKGROUND: Several frameworks now exist to guide intervention development but there remains only limited evidence of their application to health interventions based around use of mobile phones or devices, particularly in a low-resource setting. We aimed to describe our experience of using the Medical Research Council (MRC) Framework on complex interventions to develop and evaluate an adherence support intervention for high blood pressure delivered by SMS text message. We further aimed to describe the developed intervention in line with reporting guidelines for a structured and systematic description. METHODS: We used a non-sequential and flexible approach guided by the 2008 MRC Framework for the development and evaluation of complex interventions. RESULTS: We reviewed published literature and established a multi-disciplinary expert group to guide the development process. We selected health psychology theory and behaviour change techniques that have been shown to be important in adherence and persistence with chronic medications. Semi-structured interviews and focus groups with various stakeholders identified ways in which treatment adherence could be supported and also identified key features of well-regarded messages: polite tone, credible information, contextualised, and endorsed by identifiable member of primary care facility staff. Direct and indirect user testing enabled us to refine the intervention including refining use of language and testing of interactive components. CONCLUSIONS: Our experience shows that using a formal intervention development process is feasible in a low-resource multi-lingual setting. The process enabled us to pre-test assumptions about the intervention and the evaluation process, allowing the improvement of both. Describing how a multi-component intervention was developed including standardised descriptions of content aimed to support behaviour change will enable comparison with other similar interventions and support development of new interventions. Even in low-resource settings, funders and policy-makers should provide researchers with time and resources for intervention development work and encourage evaluation of the entire design and testing process. TRIAL REGISTRATION: The trial of the intervention is registered with South African National Clinical Trials Register number (SANCTR DOH-27-1212-386; 28/12/2012); Pan Africa Trial Register (PACTR201411000724141; 14/12/2013); ClinicalTrials.gov ( NCT02019823 ; 24/12/2013).
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The *STAR2D study underway has found that tailoring dietary advice to patient context is appropriate.
“For example, the *STAR2D study61 underway has found that tailoring dietary advice to patient context is appropriate.46”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [46]
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Exploring two-way text messages for post-discharge follow-up and quality improvement in rural UgandaPreprint
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- Authors
- Bobrow, K., Farmer, A., Cishe, N., Nwagi, N., Namane, M., Brennan, T. P., Springer, D., Tarassenko, L., & Levitt, N.
- Affiliations
- University of Cape Town (ZA)
- University of Oxford (GB)
- Western Cape Department of Health (ZA)
- Corresponding author
- Bobrow, Kirsten
- Venue
- BMC Health Services Research
- Published
- 2018-01-23
- Volume
- 18
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1472-6963 (ISSN-L)
- PMC
- PMC5782371
- OpenAlex
- W2787373480
- Cited by
- 46
- References
- 55
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 1 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 3
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Health Services Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open University of Cape Town (University of Cape Town) (submittedVersion)
- Funders
- Engineering and Physical Sciences Research Council (GB) and Wellcome Trust (DFR RDV0)
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Keywords
- MRC framework for complex interventions, intervention development, safety management systems, mobile health, hypertension, blood pressure control, medication adherence, behaviour change techniques, health psychology theory, resource-limited settings, user testing, stakeholder engagement, primary care
- MeSH terms
- Adult, Africa, Aged, Behavior Therapy, Female, Health Resources, Humans, Hypertension, Male, Middle Aged, Models, Theoretical, Self Care, Program Evaluation, Program Development, Focus Groups, Advisory Committees, Biomedical Research, Text Messaging
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