Preventing mental health problems in offspring by targeting dietary intake of pregnant women
Open accessAbstract
BACKGROUND: The concept of 'early life programming' considers the importance of very early environmental exposures throughout the gestational period on the subsequent health outcomes of offspring. The role of maternal dietary intake, specifically, has been highlighted after recent studies have shown maternal diet quality to predict mental health problems in offspring. Even in the pre-conception period, maternal nutrition can have permanent and sustained phenotypic consequences for offspring. DISCUSSION: Here, we consider these findings in the context of the primary prevention of mental disorders and argue that interventions that target maternal diet could be of significant value. SUMMARY: It is clear that, in order to reduce the burden of mental health issues across the lifespan, urgent action is required, particularly in the field of prevention. We thus call for the application and evaluation of targeted, primary prevention strategies that focus on dietary intake with the view to improve mental health outcomes of mothers and offspring during the postnatal period and beyond.
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Bullying victimization is strongly associated with short- and long-term vulnerability to mental illness.
“Among the possible additional risk factors, bullying victimization has been strongly associated with short-and long-term vulnerability to mental illness.11”
From Preventive strategies for mental health (2018) · cites this paper as [11]
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RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008 · see citing works
RetractedKessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · cited 1× · see citing works
“In fact, half of mental illnesses first manifest prior to 14 years of age [3] and these tend to be enduring [4].”
BackgroundMerikangas, K. R., He, J.-P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., Benjet, C., Georgiades, K., & Swendsen, J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.017 · Cited by 6,278 · see citing works
Kim-Cohen, J., Caspi, A., Moffitt, T. E., Harrington, H., Milne, B. J., & Poulton, R. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.709 · Cited by 2,025 · cited 1× · see citing works
“In fact, half of mental illnesses first manifest prior to 14 years of age [3] and these tend to be enduring [4].”
BackgroundThe Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024 · cited 1× · see citing works
“Breastfeeding is considered optimal nutrition in the first six months of life [31] for the infant due to its ability to support and develop a baby’s immune system [32], as well as prevention of later obesity, metabolic syndrome, cardiovascular disease, and behavioral and emotional problems in the child [14].”
BackgroundHibbeln, J. R., Davis, J. M., Steer, C., Emmett, P., Rogers, I., Williams, C., & Golding, J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60277-3 · Cited by 987 · cited 1× · see citing works
“For example, while large epidemiological studies have consistently shown that higher intakes of omega-3 fatty acids from fish and seafood in the diet are associated with reduced risk of depressive symptoms in the postnatal period and improved developmental outcomes in the children [45], and that poor omega-3 status is…”
ResultPsychiatric Risk Factors for Adolescent Suicide: A Case-Control Study
Brent, D. A., Perper, J. A., MORITZ, G., ALLMAN, C., FRIEND, A., ROTH, C., SCHWEERS, J., BALACH, L., & BAUGHER, M. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199305000-00006 · Cited by 863 · cited 1× · see citing works
“As childhood disorders can be a risk factor for adolescent suicide [6], as well as for a range of long-term deleterious social, criminal, and economic outcomes in adulthood [7], there”
BackgroundMediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793 · cited 1× · see citing works
“Adherence to the Mediterranean-style diet, for example, has protective effects on brain diseases, including depression [48].”
MethodDepressive Symptoms among Pregnant Women Screened in Obstetrics Settings
Marcus, S. M., Flynn, H. A., Blow, F. C., & Barry, K. L. (2003) · Journal of Women's Health · doi:10.1089/154099903765448880 · Cited by 742 · cited 1× · see citing works
“treatment options as necessary [34].”
Relationship Between Diet and Mental Health in Children and Adolescents: A Systematic Review
O’Neil, A., Quirk, S. E., Housden, S., Brennan, S. L., Williams, L. J., Pasco, J. A., Berk, M., & Jacka, F. N. (2014) · American Journal of Public Health · doi:10.2105/ajph.2014.302110 · Cited by 734 · see citing works
Self-citationPregnancy: a “teachable moment” for weight control and obesity prevention
Phelan, S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.06.008 · Cited by 637 · cited 1× · see citing works
“to frequent contact with family planning or health care providers and higher levels of motivation during this time [27].”
BackgroundDietary pattern and depressive symptoms in middle age
Akbaraly, T. N., Brunner, E. J., Ferrie, J. E., Marmot, M. G., Kivimaki, M., & Singh-Manoux, A. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.058925 · Cited by 602 · cited 1× · see citing works
“Recent evidence from observational studies suggests that habitual dietary intake can play a fundamental role in the risk for and progression of common mental disorders [12,13].”
BackgroundMakrides, M., Gibson, R. A., McPhee, A. J., Yelland, L., Quinlivan, J., Ryan, P., & DOMInO Investigative Team, A. T. (2010) · JAMA · doi:10.1001/jama.2010.1507 · Cited by 559 · see citing works
Dennis, C.-L., & McQueen, K. (2009) · Pediatrics · doi:10.1542/peds.2008-1629 · Cited by 533 · cited 1× · see citing works
“For example, the evidence suggests that maternal depression is linked to being nonresponsive to infant needs [29] and to compromised postnatal behaviors, including inadequate or absence of breastfeeding [30].”
BackgroundMaternal nutrition at conception modulates DNA methylation of human metastable epialleles
Dominguez-Salas, P., Moore, S. E., Baker, M. S., Bergen, A. W., Cox, S. E., Dyer, R. A., Fulford, A. J., Guan, Y., Laritsky, E., Silver, M. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4746 · Cited by 506 · cited 2× · see citing works
“[17] reported on women who conceived throughout different seasonal periods in Gambia, during which times food consumption is subject to pronounced variations in macro and micronutrient intake that have long been known to affect fetal growth and development.”
BackgroundLambrot, R., Xu, C., Saint‐Phar, S., Chountalos, G., Cohen, T. R., Paquet, M., Suderman, M. J., Hallett, M. T., & Kimmins, S. (2013) · Nature Communications · doi:10.1038/ncomms3889 · Cited by 476 · see citing works
The long shadow cast by childhood physical and mental problems on adult life
Goodman, A., Joyce, R., & Smith, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016970108 · Cited by 449 · cited 1× · see citing works
“As childhood disorders can be a risk factor for adolescent suicide [6], as well as for a range of long-term deleterious social, criminal, and economic outcomes in adulthood [7], there”
BackgroundSalehi-Abargouei, A., Maghsoudi, Z., Shirani, F., & Azadbakht, L. (2013) · Nutrition · doi:10.1016/j.nut.2012.12.018 · Cited by 429 · see citing works
Mediterranean dietary pattern and depression: the PREDIMED randomized trial
Sánchez-Villegas, A., Martínez-González, M. A., Estruch, R., Salas-Salvadó, J., Corella, D., Covas, M. I., Arós, F., Romaguera, D., Gómez-Gracia, E., Lapetra, J., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-208 · Cited by 403 · cited 1× · see citing works
“analyzed depression incidence in a sample of 3,923 participants at risk of cardiovascular disease after they were exposed to a dietary intervention over 3 years [49].”
BackgroundA prospective study of diet quality and mental health in adolescents
Jacka, F. N., Kremer, P. J., Berk, M., de Silva-Sanigorski, A. M., Moodie, M., Leslie, E. R., Pasco, J. A., & Swinburn, B. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024805 · Cited by 374 · cited 1× · see citing works
“Two of the three major cohort studies investigating these prospective associations yielded positive findings for the link between diet quality/variety and internalizing disorders; one in children [21] and the other in adolescent populations [22].”
BackgroundSelf-citationWomen’s Dietary Patterns Change Little from Before to During Pregnancy , ,
Crozier, S., Robinson, S. M., Godfrey, K. M., Cooper, C. C., & Inskip, H. M. (2009) · Journal of Nutrition · doi:10.3945/jn.109.109579 · Cited by 358 · cited 1× · see citing works
“However, we also know that without intervention, women do not tend to deviate from their regular dietary patterns during the early stages of pregnancy, and may even experience deterioration in their diet quality over the duration of their pregnancy [55].”
BackgroundPawlby, S. J., Hay, D. F., Sharp, D., Waters, C. S., & O’Keane, V. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.018 · Cited by 333 · cited 2× · see citing works
“The presence of antenatal depression equates to a five-fold increase in offspring developing the condition by the time they are a teenager [2].”
BackgroundSullivan, E. L., Grayson, B. E., Takahashi, D. L., Robertson, N. D., Maier, A., Bethea, C. L., Smith, M. S., Coleman, K., & Grove, K. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5560-09.2010 · Cited by 324 · cited 1× · see citing works
“While there are extensive data from animal models demonstrating the impact of nutritional exposure on parameters relating to mental health outcomes, including neurotransmitter systems [58], brain plasticity [24], and the stress response system and related behaviors in offspring [25], a detailed exposition of the propo…”
BackgroundJacka, F. N., Ystrøm, E., Brantsæter, A. L., Karevold, E., Roth, C., Haugen, M. A., Meltzer, H. M., Schjølberg, S., & Berk, M. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.07.002 · Cited by 284 · cited 3× · see citing works
“the dietary exposures were comparable to that of maternal depression, which is an established risk factor for poor mental health in children [15].”
BackgroundInfluentialSelf-citationRole of nutritional programming in determining adult morbidity.
Lucas, A. (1994) · Archives of Disease in Childhood · doi:10.1136/adc.71.4.288 · Cited by 258 · cited 2× · see citing works
“the gestational period (termed ‘early life programming’ [14]) and in early childhood has recently emerged.”
BackgroundCasacalenda, N., Perry, J. C., & Looper, K. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1354 · Cited by 247 · cited 1× · see citing works
“population [37] and may be contraindicated during preg-”
BackgroundDietary Fat Intake and the Risk of Depression: The SUN Project
Sánchez‐Villegas, A., Verberne, L. D. M., de Irala, J., Ruiz‐Canela, M., Toledo, E., Serra‐Majem, L., & Martínez‐González, M. Á. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016268 · Cited by 246 · cited 1× · see citing works
“Recent evidence from observational studies suggests that habitual dietary intake can play a fundamental role in the risk for and progression of common mental disorders [12,13].”
BackgroundOpie, R. S., O’Neil, A., Itsiopoulos, C., & Jacka, F. N. (2015) · Public Health Nutrition · doi:10.1017/s1368980014002614 · Cited by 243 · cited 1× · see citing works
“A review of randomized trials conducted by our team has highlighted the benefits of this approach for improving mental health in various medical populations [50].”
BackgroundSelf-citationInterventions to reduce or prevent obesity in pregnant women: a systematic review.
Thangaratinam, S., Rogozińska, E., Jolly, K. B., Glinkowski, S., Duda, W., Borowiack, E., Roseboom, T. J., Tomlinson, J., Walczak, J., Kunz, R., et al. (2012) · Health Technology Assessment · doi:10.3310/hta16310 · Cited by 237 · cited 1× · see citing works
“targeting physical activity [52].”
Yelland, J. S., Sutherland, G. A., & Brown, S. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-771 · Cited by 230 · cited 1× · see citing works
“It recommended routine screening and treatment of ante- and postnatal depression by upskilling healthcare professionals [35].”
BackgroundDietary Composition of Pregnant Women Is Related to Size of the Baby at Birth
Moore, V., Willson, K. J., Davies, M. J., Worsley, A. F., & Robinson, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.7.1820 · Cited by 222 · cited 1× · see citing works
“Data from the Southampton Women’s survey have shown the importance of specific macronutrients (carbohydrates during the first trimester and protein during the third trimester) on the size of offspring at birth [26].”
MethodKhoury, J., Henriksen, T., Christophersen, B. O., & Tonstad, S. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.05.016 · Cited by 216 · see citing works
Bhatia, H. S., Agrawal, R., Sharma, S., Huo, Y., Ying, Z., & Gómez‐Pinilla, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028451 · Cited by 170 · cited 2× · see citing works
“duced brain plasticity) of offspring related to mood disorders [24].”
BackgroundPerinatal Outcomes in Nutritionally Monitored Obese Pregnant Women: A Randomized Clinical Trial
Thornton, Y. S., Smarkola, C., Kopacz, S. M., & Ishoof, S. B. (2009) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30942-1 · Cited by 167 · cited 1× · see citing works
“6% [54].”
Prenatal maternal depression symptoms and nutrition, and child cognitive function
Barker, E. D., Kirkham, N. Z., Ng, J. W. Y., & Jensen, S. K. G. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.129486 · Cited by 142 · see citing works
Poston, L., Briley, A. L., Barr, S., Bell, R., Croker, H., Coxon, K., Essex, H. N., Hunt, C., Hayes, L., Howard, L. M., et al. (2013) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-13-148 · Cited by 140 · cited 1× · see citing works
“From a feasibility perspective, there are pilot data to support the contention that diet is readily modifiable in pregnant women [51].”
Backgroundde Jersey, S., Nicholson, J. M., Callaway, L. K., & Daniels, L. (2013) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-13-115 · Cited by 136 · see citing works
Steenweg-de Graaff, J., Tiemeier, H., Steegers-Theunissen, R. P. M., Hofman, A., Jaddoe, V. W. V., Verhulst, F. C., & Roza, S. J. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2013.03.002 · Cited by 134 · see citing works
Early life programming as a target for prevention of child and adolescent mental disorders
Lewis, A. J., Galbally, M., Gannon, T., & Symeonides, C. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-33 · Cited by 133 · cited 1× · see citing works
“The reasons for this are multifaceted and likely have an epigenetic and behavioral basis [28].”
BackgroundA systematic review of the effect of diet in prostate cancer prevention and treatment
W.‐L., R., & Chapman, K. L. (2009) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2009.00946.x · Cited by 125 · cited 1× · see citing works
“In contrast, such strategies to reduce the incidence of high prevalence, chronic somatic conditions as, for example, cardiovascular disease and some cancers, have been effective over past decades [9,10]; dietary improvement, in particular, has been demonstrated to be an effective approach [11].”
BackgroundMoran, L., Sui, Z., Cramp, C., & Dodd, J. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.129 · Cited by 120 · cited 1× · see citing works
“women to consume a ‘high-energy’ diet in later stages of pregnancy, when compared with pre-pregnancy [56].”
BackgroundLow Omega-3 Index in Pregnancy Is a Possible Biological Risk Factor for Postpartum Depression
Markhus, M. W., Skotheim, S., Graff, I. E., Frøyland, L., Braarud, H. C., Stormark, K. M., & Kjellevold, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067617 · Cited by 116 · cited 1× · see citing works
“For example, while large epidemiological studies have consistently shown that higher intakes of omega-3 fatty acids from fish and seafood in the diet are associated with reduced risk of depressive symptoms in the postnatal period and improved developmental outcomes in the children [45], and that poor omega-3 status is…”
ResultThe Origins and Course of Common Mental Disorders
Goldberg, P. D., & Goodyer, I. M. (2014) · Routledge eBooks · doi:10.4324/9781315820149 · Cited by 114 · see citing works
The origins of health and disease: the influence of maternal diseases and lifestyle during gestation
Capra, L., Tezza, G., Mazzei, F., & Boner, A. L. (2013) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-39-7 · Cited by 100 · cited 1× · see citing works
“During pregnancy, and particularly early pregnancy, exposure of the developing fetus to an unfavorable environment predisposes the unborn child to numerous chronic diseases [23].”
BackgroundKieffer, E. C., Caldwell, C. H., Welmerink, D. B., Welch, K. B., Sinco, B. R., & Guzmán, J. R. (2012) · American Journal of Community Psychology · doi:10.1007/s10464-012-9523-9 · Cited by 96 · cited 1× · see citing works
“However, most trials conducted in this area have focused on obesity prevention with only several specifically focused on mental health outcomes [47].”
BackgroundTuccori, M., Testi, A., Antonioli, L., Fornai, M., Montagnani, S., Ghisu, N., Colucci, R., Corona, T., Blandizzi, C., & Tacca, M. D. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.07.009 · Cited by 95 · cited 1× · see citing works
“For example, while pharmacotherapy targets the physiological genesis of depression encompassing reduced dopamine, serotonin, and norepinephrine levels, and alterations in hormones and neuro-membranes, there have been safety concerns surrounding the use of some therapeutic agents in pregnancy [38].”
BackgroundMaternal depression and dyadic interaction: the role of maternal attachment style
Flykt, M. S., Kanninen, K. M., Sinkkonen, J., & Punamäki, R. (2010) · Infant and Child Development · doi:10.1002/icd.679 · Cited by 94 · see citing works
Community-Based Prevention Programs for Anxiety and Depression in Youth: A Systematic Review
Christensen, H., Pallister, E., Smale, S., Hickie, I. B., & Calear, A. L. (2010) · The Journal of Primary Prevention · doi:10.1007/s10935-010-0214-8 · Cited by 93 · cited 1× · see citing works
“Preventive interventions for mental disorders in children and adolescents have often involved the use of established psycho-therapeutic approaches, delivered in community, school, and online settings [8], but have not employed approaches to primary prevention that focus on lifestyle modification.”
BackgroundPredictors of Dietary Quality in Low-Income Pregnant Women
Fowles, E. R., Bryant, M., Kim, S., Walker, L. O., Ruiz, R. J., Timmerman, G. M., & Brown, A. (2011) · Nursing Research · doi:10.1097/nnr.0b013e3182266461 · Cited by 67 · see citing works
The lifetime prevalence of mental disorders: estimation, uses and limitations
Kramer, M., Korff, M. V., & Kessler, L. G. (1980) · Psychological Medicine · doi:10.1017/s0033291700047310 · Cited by 53 · see citing works
Eating at Fast-Food Restaurants and Dietary Quality in Low-Income Pregnant Women
Fowles, E. R., Timmerman, G. M., Bryant, M., & Kim, S. H. (2010) · Western Journal of Nursing Research · doi:10.1177/0193945910389083 · Cited by 51 · cited 1× · see citing works
“Overall trends suggest that poor quality maternal diet is associated with antenatal depressive [40-42], anxiety [43], and stress symptoms [41,42] as well as postpartum depressive symptoms [40].”
BackgroundNutritional interventions in depression and perinatal depression.
Rechenberg, K., & Humphries, D. L. (2013) · Europe PMC (PubMed Central) · Cited by 49 · see citing works
Vaz, J. D. S., Kac, G., Emmett, P. M., Davis, J. M., Golding, J., & Hibbeln, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067671 · Cited by 47 · cited 2× · see citing works
“, vegetables, lean red meat, poultry) was reviewed, healthy diets were inversely associated with antenatal and postpartum depressive symptoms [40] and antenatal anxiety [43].”
BackgroundPrenatal exposure to maternal obesity leads to hyperactivity in offspring
Fernandes, C., Grayton, H. M., Poston, L., Samuelsson, A.-M., Taylor, P. D., Collier, D. A., & Rodriguez, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.164 · Cited by 39 · cited 2× · see citing works
“, high saturated fats and high added sugar) on the activation of the sympathetic nervous system and hyperactivity behaviors, which may have implications for behaviors related to adult mood disorders [25].”
BackgroundFisher, J., Chatham, E., Haseler, S., McGaw, B., & Thompson, J. (2012) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12000 · Cited by 30 · cited 1× · see citing works
“variability in how this is carried out in regards to gestational stage, scoring, and response/s to potential depression [36].”
BackgroundPrevention of Schizophrenia--Will a Broader Prevention Agenda Support This Aim?
Jacka, F. N., & Berk, M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt202 · Cited by 12 · see citing works
Self-citationKieffer, E. C., Caldwell, C. H., Welmerink, D. B., Welch, K. B., Sinco, B. R., & Guzmán, J. R. (2013) · American Journal of Community Psychology · doi:10.1007/s10464-013-9568-4 · Cited by 1 · see citing works
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Preventive strategies for mental health
Arango, C., Díaz-Caneja, C. M., McGorry, P. D., Rapoport, J., Sommer, I. E., Vorstman, J. A., McDaid, D., Marín, O., Serrano-Drozdowskyj, E., Freedman, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30057-9 · Cited by 1,271 · see citing works
“24 Even when there is a “first hit” or further “hits”, the effect could be lessened by enhancing protective factors such as family and social support and promoting resilience.”
Diet and depression: Exploring the biological mechanisms of action
Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00925-x · Cited by 685 · see citing works
“Environmental influence during the sensitive periods of prenatal development, gamete formation, and adolescence has been linked with risk for chronic diseases that share common pathways with depression, including cardiometabolic and neurodevelopmental disorders [159].”
BackgroundSelf-citationA review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis
Davis, J., Eyre, H. A., Jacka, F. N., Dodd, S., Dean, O. M., McEwen, S. C., Debnath, M., McGrath, J. J., Maes, M. H. J., Amminger, G. P., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.017 · Cited by 358 · see citing works
“long term benefits on diverse neurocognitive outcomes (Jacka and Berk, 2014; O’Neil et al., 2014).”
BackgroundSelf-citationDietary recommendations for the prevention of depression
Opie, R. S., Itsiopoulos, C., Parletta, N., Sanchez-Villegas, A., Akbaraly, T. N., Ruusunen, A., & Jacka, F. N. (2017) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000043 · Cited by 287 · see citing works
Self-citationNutritional Psychiatry: Where to Next?
Jacka, F. N. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.02.020 · Cited by 253 · see citing works
“A systematic review in 2014 confirmed an association between higher unhealthy diets and poor mental health in children and adolescents (O'Neil et al., 2014a), although this review now requires updating.”
BackgroundSelf-citationEarly-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Spann, M. N., Monk, C. E., Scheinost, D., & Peterson, B. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2272-17.2018 · Cited by 183 · see citing works
“…levels may simply index poor general and mental health (Wium-Andersen et al., 2013; Shanahan et al., 2014), which can themselves alter brain development and behavioral outcomes in offspring (Chittleborough et al., 2012; O’Neil et al., 2014) and could therefore account for some of our observations.”
ResultMaternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring
Banik, A., Kandilya, D., Ramya, S., Stünkel, W., Chong, Y. S., & Dheen, S. T. (2017) · Genes · doi:10.3390/genes8060150 · Cited by 157 · see citing works
“Hence, early intervention by supplementing the maternal diet with DNA methylating agents at gestation would be helpful in maintaining the healthy development of the fetus [219].”
BackgroundNutritional Aspects of Depression in Adolescents - A Systematic Review
Khanna, P., Chattu, V. K., & Aeri, B. T. (2019) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_400_18 · Cited by 111 · see citing works
“[13,14] This suggests the potential to target the nutritional status of a woman during pregnancy in order to positively influence future mental health outcomes in children and adolescents.[15]”
BackgroundBorges-Vieira, J. G., & Cardoso, C. K. S. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2031494 · Cited by 74 · see citing works
“women [7,8], and exposure to toxic metals during pregnancy [9] may be related to the development of these disorders.”
BackgroundLogan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-015-0041-y · Cited by 69 · see citing works
Hill, B., Skouteris, H., Teede, H. J., Bailey, C., Baxter, J.-A. B., Bergmeier, H. J., Borges, A. L. V., Harrison, C. L., Jack, B., Jorgensen, L., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122119 · Cited by 65 · see citing works
Self-citationJiang, W., Mo, M., Li, M., Wang, S., Muyiduli, X., Shao, B., Jiang, S. S., & Yu, Y. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13728 · Cited by 52 · see citing works
Antenatal dietary patterns and depressive symptoms during pregnancy and early post‐partum
Baskin, R., Hill, B., Jacka, F. N., O'Neil, A. E., & Skouteris, H. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12218 · Cited by 52 · see citing works
Self-citationThe Importance of Diet and Gut Health to the Treatment and Prevention of Mental Disorders
Dawson, S. L., Dash, S. R., & Jacka, F. N. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.009 · Cited by 47 · see citing works
“Although requiring updating, existing systematic reviews confirm a relationship between diet quality and mental health in children and adolescence (O’Neil et al., 2014).”
BackgroundSelf-citationGaléra, C., Heude, B., Forhan, A., Bernard, J. Y., Peyre, H., van der Waerden, J. E. B., Pryor, L., Bouvard, M. P., Melchior, M., Lioret, S., et al. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12898 · Cited by 46 · see citing works
“, cancer, cardiovascular diseases, diabetes, obesity), the literature on diet has recently widened its scope to include mental health and neurodevelopmental outcomes (Jacka, Sacks, Berk, & Allender, 2014; Logan & Jacka, 2014; O’Neil et al., 2014).”
InfluentialHill, B., Skouteris, H., Boyle, J. A., Bailey, C., Walker, R., Thangaratinam, S., Sundseth, H., Stephenson, J., Steegers, E. A. P., Redman, L. M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030822 · Cited by 44 · see citing works
“Diet quality in pregnancy is associated with poorer mental health, with both causal [43] and bi-directional [44] relationships implicated.”
BackgroundSelf-citationOpie, R., Neff, M., & Tierney, A. C. (2016) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12474 · Cited by 43 · see citing works
Self-citationLogan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-014-0040-4 · Cited by 42 · see citing works
“Moreover, the perinatal period represents a highly sensitive period in which dietary experience may dictate subsequent food preferences and mental outlook over the offspring life course [64,65].”
BackgroundPolańska, K., Kałużny, P., Aubert, A. M., Bernard, J. Y., Duijts, L., Marroun, H. E., Hanke, W., Hébert, J. R., Heude, B., Jankowska, A., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.10.008 · Cited by 41 · see citing works
Schroeder, M., Jakovcevski, M., Polacheck, T., Lebow, M., Drori, Y., Engel, M., Ben‐Dor, S., & Chen, A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.001 · Cited by 37 · see citing works
“While a recent advance was achieved by targeting thematernal diet duringgestationasmeansofpreventionof mental illness (O’Neil et al., 2014), we show that an adequate diet during adolescence can significantly ameliorate the repercussion of PNSbyblocking the acquired epigenetic defect in the…”
BackgroundHuman Milk Omega-3 Fatty Acid Composition Is Associated with Infant Temperament
Hahn‐Holbrook, J., Fish‐Williamson, A., & Glynn, L. M. (2019) · Nutrients · doi:10.3390/nu11122964 · Cited by 33 · see citing works
“While this possibility is only hypothetical, maternal diets during pregnancy and lactation are modifiable and present promising targets for the prevention of adverse developmental outcomes in children [52,53].”
BackgroundDiet and Common Mental Disorders: The Imperative to Translate Evidence into Action
Dash, S. R., O'Neil, A. E., & Jacka, F. N. (2016) · Frontiers in Public Health · doi:10.3389/fpubh.2016.00081 · Cited by 26 · see citing works
“Given that pregnancy provides a unique “teachable moment,” where mothers are particularly open to receiving health advice and making behavior change, such a targeted approach to prevention of the CMDs may prove to be feasible (49) and have important implications for the mental health of offspring.”
BackgroundSelf-citationThe impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
Sarkisova, K. Y., & van Luijtelaar, G. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.10.012 · Cited by 26 · see citing works
Maternal Nutrition during Pregnancy and Offspring Brain Development: Insights from Neuroimaging
Na, X., Mackean, P. P., Cape, G. A., Johnson, J. W., & Ou, X. (2024) · Nutrients · doi:10.3390/nu16193337 · Cited by 22 · see citing works
“…neurodevelopmental or neuropsychiatric disorders (e.g., ASD, attention-deficit/hyperactivity disorder, schizophrenia, anxiety, depression) [6,14,15], behavioral disorders [6,15], altered cognition (e.g., learning difficulties, decreased IQ, poorer language and memory development) [6,16,17],…”
BackgroundRole of the imprinted allele of the Cdkn1c gene in mouse neocortical development
Imaizumi, Y., Furutachi, S., Watanabe, T., Miya, H., Kawaguchi, D., & Gotoh, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-58629-9 · Cited by 18 · see citing works
Collet, O. A., Heude, B., Forhan, A., Delcourt, C., Orri, M., van der Waerden, J. E. B., Melchior, M., Côté, S. M., Lioret, S., de Lauzon‐Guillain, B., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa343 · Cited by 17 · see citing works
Maternal Mental Health and Offspring Brain Development: An Umbrella Review of Prenatal Interventions
Lugo-Candelas, C. I., Talati, A., Glickman, C., Hernández, M., Scorza, P., Monk, C. E., Kubo, A., Wei, C., Sourander, A., & Duarte, C. S. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.01.026 · Cited by 15 · see citing works
“In response, it has been proposed that whole-diet intervention approaches may be needed, as there could be a number of nutrients and in fi nite combinations of these necessary to have an effect on prenatal distress and prevent intergenerational transmission (23,24).”
BackgroundSzewczyk, Z., Holliday, E. G., Dean, B., Collins, C. E., & Reeves, P. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa015 · Cited by 16 · see citing works
Che, X., Gross, S. M., Wang, G., Hong, X., Pearson, C., Bartell, T. R., & Wang, X. (2023) · PubMed Central · doi:10.1097/pn9.0000000000000047 · Cited by 13 · see citing works
What doesn’t kill her, will make her depressed
Li, Y., & Sunder, N. (2021) · Economics & Human Biology · doi:10.1016/j.ehb.2021.101064 · Cited by 12 · see citing works
Gao, Y., & Zhou, T. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104596 · Cited by 10 · see citing works
Perinatal diet and offspring anxiety: A scoping review
Monteiro, S., Nejad, Y. S., & Aucoin, M. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0242 · Cited by 10 · see citing works
“[2] O’Neil A, Itsiopoulos C, Skouteris H, Opie RS, McPhie S,”
BackgroundInfluentialImportance of the Microbiota in Early Life and Influence on Future Health
Verdu, E. F., Hayes, C. L., & O’Mahony, S. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00009-8 · Cited by 9 · see citing works
Madeghe, B. A., Kogi‐Makau, W., Ngala, S., & Kumar, M. (2021) · Global Social Welfare · doi:10.1007/s40609-020-00199-9 · Cited by 8 · see citing works
“Thus, pregnancy represents a unique opportunity in life with considerable possibility to influence maternal health and the health of the next generation (O'Neil et al. 2014).”
BackgroundMadeghe, B. A., Kogi‐Makau, W., Ngala, S., & Kumar, M. (2021) · Food and Nutrition Bulletin · doi:10.1177/03795721211025123 · Cited by 8 · see citing works
“Conclusive evidence on nutritional enhancement as a treatment strategy for depression is still lacking.(13,21,22) Given this backdrop, the overall objective of this article is to identify nutritional factors associated with maternal depression among pregnant women in 2 urban low-income settlements in Nairobi, Kenya, w…”
BackgroundAndrade, E. B., Lorga, I., Roque, S., Geraldo, R., Mesquita, P., Castro, R., Costa, A. L., Costa, M. M., Faustino, A., Ribeiro, A., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.04.004 · Cited by 7 · see citing works
Rahe, C., & Berger, K. (2016) · Springer eBooks · doi:10.1007/978-3-319-32480-7_17 · Cited by 6 · see citing works
Effect of Per and Poly-Fluoroalkyl Substances on Pregnancy and Child Development
Kilari, T., Suresh, A. S., Begum, R. F., Singh, A., Venkkatesh, P., & Vellapandian, C. (2024) · Current Pediatric Reviews · doi:10.2174/0115733963267526231120110100 · Cited by 6 · see citing works
Takaful Protection for Mental Health Illness From the Perspective of Maqasid Shariah
Khairi, K. F., Samat, M. S. A., Laili, N. H., Sabri, H., Basah, M. Y. A., Haris, A., & Mirza, A. A. I. (2020) · International Journal of Financial Research · doi:10.5430/ijfr.v11n3p168 · Cited by 6 · see citing works
“Mental health problem could even affect an offspring through parents (O‟Neil et al., 2014).”
BackgroundMaternal obesity reprograms offspring's executive brain centers in a sex‐specific manner?
Plucińska, K., & Barger, S. W. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14334 · Cited by 5 · see citing works
“Exposure of the developing fetus to an unfavorable environment may predispose the unborn child to reduced brain plasticity (Moody et al. 2017) and complex neurological disorders such as depression (O’Neil et al. 2014), autism, and attention deficit hyperactivity disorder (Andersen et al. 2017).”
BackgroundZweifler, G., Zimny-Zając, A., Babicki, M., Kłoda, K., Mazur, G. J., Jankowska‐Polańska, B., Mastalerz–Migas, A., & Agrawal, S. (2025) · Nutrients · doi:10.3390/nu17182924 · Cited by 3 · see citing works
“…while those consuming vegetables and fruits daily reported better mental well-being, a finding consistent with a growing body of evidence linking poor diet quality to adverse psychological outcomes through mechanisms like inflammation, gut microbiota disruption, and glycemic variability [37–39].”
Editorial: Dietary diversity indicators: cultural preferences and health outcomes
Kobayashi, M., & Thielecke, F. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1433735 · Cited by 2 · see citing works
Integrative Approaches to Perinatal Depression
Pirec, V., & Brogan, K. (2015) · CRC Press eBooks · doi:10.1201/b19089-29 · Cited by 1 · see citing works
Nutrition: A dimensional perspective
Pentz, J. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2015.03.003
Arango, C., & Serrano-Drozdowskyj, E. (2016)
Role of the imprinted allele of the p57 Kip2 gene in mouse neocortical developmentPreprint
Imaizumi, Y., Furutachi, S., Watanabe, T., Miya, H., Kawaguchi, D., & Gotoh, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/737692
Dietary assessment, nutrition knowledge, and pregnancy outcome in high-risk pregnant Korean women
Kim, M. J., Lim, H., Lee, H., Kim, T., & Park, Y. (2021) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4805188
“Modifying dietary habits during pregnancy can have tremendous results [21]; therefore, pregnancy is a good opportunity to set the foundation of nutritional knowledge and to establish better habits and make an effort to maintain them [22].”
BackgroundMaternal insulinemic and inflammatory dietary patterns and risk of child neurodevelopmental delay
Wang, H., Zu, P., Yin, W., Zhang, L., Ruan, L., Chen, X., & Zhu, P. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03531-7
Why do adults get depressed? The role of in utero malnutrition and son-preferencePreprint
Wang, Y., & He, P. (2023) · Research Square · doi:10.21203/rs.3.rs-2905897/v1
- Authors
- O'Neil, A., Itsiopoulos, C., Skouteris, H., Opie, R. S., McPhie, S., Hill, B., & Jacka, F. N.
- Affiliations
- Deakin University (AU)
- La Trobe University (AU)
- The Royal Melbourne Hospital (AU)
- Corresponding author
- O'Neil, Adrienne
- ORCID
- Venue
- BMC Medicine
- Published
- 2014-11-14
- Volume
- 12
- Issue
- 1
- Pages
- 208-208
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC4231189
- OpenAlex
- W1991455527
- Cited by
- 51
- References
- 58
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 6
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (1052865)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- maternal diet, maternal nutrition, offspring mental health, early life programming, prenatal exposure, primary prevention, mental illness, postpartum period, diet quality
- MeSH terms
- Child, Child Behavior Disorders, Diet, Female, Humans, Pregnancy, Prenatal Care, Prenatal Exposure Delayed Effects
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