The DOI matches its Crossref record; 123 of the 125 references it cites were found in a registry or an index.
Mangiferin: a natural miracle bioactive compound against lifestyle related disorders
Open accessAbstract
The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.
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![Fig. 2 Inhibition of NFκB via the (A) classical and (B) alternative pathways by mangiferin (adapted from [11, 45, 55, 123, 124])](/paper-figures/bed95bf082554460936c37ebbb61fb3a/mangiferin-a-natural-miracle-bioactive-compound-against-lifestyle-related-figure-2.jpg)
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“It has been widely reported that MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects [20,21].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [20]
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Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · cited 1×
“also induces apoptosis and inhibits the progression and promotion of cell proliferation by interfering with cell cycle regulation, the signaling of several cancer transduction pathways in tumor cells [21].”
Background[36] Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
Bors, W., Heller, W. E., Michel, C., & Sarán, M. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86128-i · Cited by 1,726
The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
Hollman, P. C. H., Bijsman, M. N. C. P., van Gameren, Y., Cnossen, E. P. J., de Vries, J. H. M., & Katan, M. (1999) · Free Radical Research · doi:10.1080/10715769900301141 · Cited by 555
Molecular Link Mechanisms between Inflammation and Cancer
Costa, D. B. V., & de Carvalho, J. E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802083707 · Cited by 426
Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426
Topical and Peripherally Acting Analgesics
Sawynok, J. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.1 · Cited by 347
Microwave-assisted extraction of flavonoids from Radix Astragali
Xiao, W., Han, L., & Shi, B. (2008) · Separation and Purification Technology · doi:10.1016/j.seppur.2008.03.025 · Cited by 304
Martı́nez-Sánchez, G., Re, L., Giuliani, A., Sellés, A. J. N., Pérez-Davison, G., & León-Fernández, O. S. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0727 · Cited by 302
Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289
Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation
Cholbi, M. R., Payá, M., & Alcaraz, M. J. (1991) · Cellular and Molecular Life Sciences · doi:10.1007/bf01945426 · Cited by 265
Cited by
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Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction
Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 611
Chemical Composition of Mango (Mangifera indica L.) Fruit: Nutritional and Phytochemical Compounds
Celis, M. E. M., Yahia, E. M., Bedoya, R. A., Landázuri, P., Loango, N., Osma, J. A., Restrepo, B., & Ospina, J. C. G. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01073 · Cited by 563
Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit
Lebaka, V. R., Wee, Y., Ye, W., & Korivi, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020741 · Cited by 439
Yaashikaa, P. R., Kumar, P. S., & Varjani, S. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126126 · Cited by 405
Mangiferin: A comprehensive review on its extraction, purification and uses in food systems
Castro-Muñoz, R., Cabezas, R., & Plata-Gryl, M. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103188 · Cited by 165
Metadata
- Authors
- Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T.
- Affiliations
- Imperial College of Business Studies (PK)
- Government College University, Faisalabad (PK)
- University of Agriculture Faisalabad (PK)
- Kyungpook National University (KR)
- Bahauddin Zakariya University (PK)
- Corresponding author
- Arshad, Muhammad Sajid
- Arshad, Muhammad Umair
- ORCID
- Venue
- Lipids in Health and Disease
- Published
- 2017-05-02
- Volume
- 16
- Issue
- 1
- Pages
- 84-84
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC5414237
- OpenAlex
- W2610241935
- Cited by
- 366
- References
- 125
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 57 · 2023: 59 · 2022: 39 · 2021: 42 · 2020: 41 · 2019: 31 · 2018: 11 · 2017: 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- mangiferin, mango, lifestyle-related diseases, antioxidant activity, antidiabetic activity, anticancer activity, neuroprotection, breast cancer, lung cancer, colon cancer, MMP-9, matrix metalloproteinase-7, β-catenin signaling, TNF-α, inducible nitric oxide synthase, apoptosis, immunomodulation, antimicrobial activity, hypocholesterolemic activity, xanthones
- MeSH terms
- Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Hyperlipidemias, Hypoglycemic Agents, Neoplasms, Neuralgia, Oxidative Stress, Nootropic Agents, Mangifera, Xanthones, Cognitive Dysfunction
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