Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

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The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man

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Molecular Link Mechanisms between Inflammation and Cancer

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Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats

Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426

Topical and Peripherally Acting Analgesics

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Microwave-assisted extraction of flavonoids from Radix Astragali

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Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice

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Analgesic and antioxidant activity of mangiferin and its derivatives: The structure activity relationship

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Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation

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Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats

Muruganandan, S., Gupta, S., Kataria, M., Lal, J., & Gupta, P. K. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00069-0 · Cited by 216

Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats

Pal, P. B., Sinha, K., & Sil, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107220 · Cited by 185

Of the Major Phenolic Acids Formed during Human Microbial Fermentation of Tea, Citrus, and Soy Flavonoid Supplements, Only 3,4-Dihydroxyphenylacetic Acid Has Antiproliferative Activity ,

Gao, K., Xu, A., Krul, C. A. M., Venema, K., Liu, Y., Niu, Y., Lu, J., Bensoussan, L., Seeram, N. P., Heber, D., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.52 · Cited by 183

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

Das, J., Ghosh, J., Roy, A., & Sil, P. C. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.015 · Cited by 173

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

García-Rivera, D., Delgado, R., Bougarne, N., Haegeman, G., & Vanden Berghe, W. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.011 · Cited by 142

Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia

Gottlieb, M., Leal-Campanario, R., Campos-Esparza, M. R., Sánchez-Gómez, M. V., Alberdi, E., Arranz, A., Delgado-García, J. M., Gruart, A., & Matute, C. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.03.017 · Cited by 141

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

Dou, W., Zhang, J., Ren, G., Ding, L., Sun, A., Deng, C., Wu, X., Wei, X., Mani, S., & Wang, Z. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.08.025 · Cited by 137

Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice

Jangra, A., Lukhi, M. M., Sulakhiya, K., Baruah, C. C., & Lahkar, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.031 · Cited by 122

Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate

Andreu, G. P., Delgado, R., Velho, J. A., Curti, C., & Vercesi, A. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.007 · Cited by 122

Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Li, Y., Huang, T. H.-W., & Yamahara, J. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.005 · Cited by 119

Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters

Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Feng, R., Li, Y., & Sun, C. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100392 · Cited by 118

Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK

Niu, Y., Li, S., Na, L., Feng, R., Liu, L., Li, Y., & Sun, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030782 · Cited by 116

Mangiferin – a Bioactive Xanthonoid, not only from Mango and not just Antioxidant

Matkowski, A., Kus, P., Goralska, E., & Wozniak, D. (2013) · Mini Reviews in Medicinal Chemistry · doi:10.2174/138955713804999838 · Cited by 116

Mangiferin decreases inflammation and oxidative damage in rat brain after stress

Márquez, L., García-Bueno, B., Madrigal, J. L. M., & Leza, J. C. (2012) · European Journal of Nutrition · doi:10.1007/s00394-011-0252-x · Cited by 111

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

Song, J., Li, J., Hou, F., Wang, X., & Liu, B. (2015) · Metabolism · doi:10.1016/j.metabol.2014.11.008 · Cited by 109

Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin

García, D., Escalante, M., Delgado, R., Ubeira, F. M., & Leiro, J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1343 · Cited by 109

Improving permeability and oral absorption of mangiferin by phospholipid complexation

Ma, H., Chen, H., Sun, L., Tong, L., & Zhang, T. (2014) · Fitoterapia · doi:10.1016/j.fitote.2013.10.016 · Cited by 108

Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway

Li, H., Huang, J., Yang, B. L., Xiang, T., Yin, X., Peng, W., Cheng, W., Wan, J., Luo, F., Li, H., et al. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.011 · Cited by 106

Ethnopharmacology of Mangifera indica L. Bark and Pharmacological Studies of its Main C-Glucosylxanthone, Mangiferin

Wauthoz, N., Balde, A. M., Baldé, E. S., Damme, M. V., & Duez, P. (2007) · Cited by 102

Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level

Kasbe, P., Jangra, A., & Lahkar, M. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2015.04.002 · Cited by 98

Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways

Pal, P. B., Sinha, K., & Sil, P. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056894 · Cited by 98

Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells

Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C. P., Olajide, O. A., Martínez-Sánchez, G., & Fiebich, B. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.017 · Cited by 95

Effects of a natural extract from Mangifera indica L, and its active compound, mangiferin, on energy state and lipid peroxidation of red blood cells

Rodríguez, J., Pierro, D. D., Gioia, M., Monaco, S., Delgado, R., Coletta, M., & Marini, S. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.04.005 · Cited by 94

Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

He, L., Peng, X., Zhu, J., Chen, X., Liu, H., Tang, C., Dong, Z., Liu, F., & Peng, Y. (2014) · American Journal of Nephrology · doi:10.1159/000369220 · Cited by 93

Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice

Kavitha, M., Nataraj, J., Essa, M. M., Memon, M. A., & Manivasagam, T. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.09.016 · Cited by 91

Mangiferin prevents diabetic nephropathy progression in streptozotocin‐induced diabetic rats

Li, X., Cui, X., Sun, X., Li, X., Zhu, Q., & Li, W. (2010) · Phytotherapy Research · doi:10.1002/ptr.3045 · Cited by 91

Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms

Herranz‐López, M., Barrajón‐Catalán, E., Segura‐Carretero, A., Menéndez, J. A., Joven, J., & Micol, V. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.03.015 · Cited by 85

Conformational Differences Between O- and C-Glycosides: Theα-O-Man-(1→1)-β-Gal/α-C-Man-(1→1)-β-Gal Case- A Decisive Demonstration of the Importance of theexo-Anomeric Effect on the Conformation of Glycosides

Asensio, J. L., Cañada, F. J., Cheng, X., Khan, N., Mootoo, D. R., & Jiménez‐Barbero, J. (2000) · Chemistry - A European Journal · doi:10.1002/(sici)1521-3765(20000317)6:6 · Cited by 84

Fungal transformation of ferulic acid from sugar beet pulp to natural vanillin

Lesage‐Meessen, L., Stentelaire, C., Lomascolo, A., Couteau, D., Asther, M., Moukha, S., Record, É., Sigoillot, J., & Asther, M. (1999) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(19990301)79:3 · Cited by 83

Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: Role of adiponectin and TNF-α

SALEH, S., EL-MARAGHY, N., REDA, E., & BARAKAT, W. (2014) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201420140212 · Cited by 81

Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1

Gong, X., Zhang, L., Jiang, R., Ye, M., Yin, X., & Wan, J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.09.003 · Cited by 80

Gastroprotective Effect of Mangiferin, a Xanthonoid from Mangifera indica, against Gastric Injury Induced by Ethanol and Indomethacin in Rodents

Carvalho, A. M., Guedes, M., de Souza, A. Q. L., Trevisan, M. T. S., de Lima, A. K. M. M. N., Santos, F. A., & Rao, V. S. N. (2007) · Planta Medica · doi:10.1055/s-2007-990231 · Cited by 80

Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways

Jeong, J.-J., Jang, S.-E., Hyam, S. R., Han, M. J., & Kim, D.-H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.013 · Cited by 78

Total Synthesis of Flavocommelin, a Component of the Blue Supramolecular Pigment from Commelina communis, on the Basis of Direct 6-C-Glycosylation of Flavan

Oyama, K., & Kondo, T. (2004) · The Journal of Organic Chemistry · doi:10.1021/jo0494681 · Cited by 78

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

Liu, Y., Zhu, X., Yang, Q., Lü, Q., Wang, J., Li, H.-P., Wei, Y., Yin, J., & Yin, X. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3061-5 · Cited by 77

Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages

Muruganandan, S., Lal, J., & Gupta, P. K. (2005) · Toxicology · doi:10.1016/j.tox.2005.06.008 · Cited by 77

Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL‐induced activation of NF‐κB and ERK

Ang, E. S. M., Liu, Q., Qi, M., Liu, H. G., Yang, X., Chen, H., Zheng, M., & Xu, J. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22800 · Cited by 75

Mangiferin Ameliorates Scopolamine-Induced Learning Deficits in Mice

Jung, K., Lee, B., Han, S. J., Ryu, J. H., & Kim, D.-H. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.242 · Cited by 75

Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma

Rivera, D. G., Hernández, I., Merino, N., Luque, Y., Álvarez, A., Martín, Y., Amador, A., Nuevas, L., & Delgado, R. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01328.x · Cited by 74

Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets

Rajendran, P., Rengarajan, T., Nandakumar, N., Divya, H., & Nishigaki, I. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.931431 · Cited by 71

Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats

Andreu, G. L. P., Maurmann, N., Reolon, G. K., de Farias, C. B., Schwartsmann, G., Delgado, R., & Roesler, R. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.011 · Cited by 71

Mangiferin from Salacia chinensis Prevents Oxidative Stress and Protects Pancreatic β -Cells in Streptozotocin-Induced Diabetic Rats

Sellamuthu, P. S., Arulselvan, P., Muniappan, B. P., Fakurazi, S., & Kandasamy, M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2480 · Cited by 70

Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes

Jagetia, G. C., & Venkatesha, V. A. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20124 · Cited by 70

Mangiferin ameliorates 6-hydroxydopamineinduced cytotoxicity and oxidative stress in ketamine model of schizophrenia

Rao, V. S. N., Carvalho, A. C. S., Trevisan, M. T. S., de Andrade, G. M., Júnior, H. V. N., de Moraes, M. O., Iury, H. I. M. H., Morais, T. C., & Santos, F. A. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70879-4 · Cited by 69

Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets

Apontes, P., Liu, Z., Su, K., Benard, O., Youn, D. Y., Li, X., Li, W., Mirza, R. H., Bastie, C. C., Jelicks, L. A., et al. (2014) · Diabetes · doi:10.2337/db14-0006 · Cited by 69

Fe(III) improves antioxidant and cytoprotecting activities of mangiferin

Pardo‐Andreu, G. L., Sánchez-Baldoquín, C., Ávila-González, R., Delgado, R., Naal, Z., & Curti, C. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.040 · Cited by 67

Mangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell line

Pan, L.-L., Wang, A.-Y., Huang, Y.-Q., Luo, Y., & Ling, M. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.17.7065 · Cited by 66

Mangiferin Attenuates Renal Fibrosis Through Down-Regulation of Osteopontin in Diabetic Rats: EFFECTS OF MANGIFERIN ON RENAL FIBROSIS IN DIABETES

Zhu, X., Cheng, Y.-Q., Du, L., Li, Y., Zhang, F., Guo, H., Liu, Y.-W., & Yin, X.-X. (2015) · Phytotherapy Research · doi:10.1002/ptr.5254 · Cited by 66

Synthesis of Mangiferin, Isomangiferin, and Homomangiferin

Wu, Z., Guo, W., Lian, G., & Yu, B. (2010) · The Journal of Organic Chemistry · doi:10.1021/jo100776q · Cited by 66

Mangiferin, a natural occurring glucosyl xanthone, increases susceptibility of rat liver mitochondria to calcium-induced permeability transition

Pardo‐Andreu, G. L., Delgado, R., Velho, J. A., Curti, C., & Vercesi, A. E. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.05.015 · Cited by 66

Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells

Amazzal, L., Lapôtre, A., Quignon, F., & Bagrel, D. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.025 · Cited by 65

Structure elucidation of in vivo and in vitro metabolites of mangiferin

Liu, H., Wang, K., Tang, Y., Sun, Z., Jian, L., Li, Z., Wu, B., & Huang, C. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.03.012 · Cited by 65

Dual mode action of mangiferin in mouse liver under high fat diet

Lim, J., Liu, Z., Apontes, P., Feng, D., Pessin, J. E., Sauve, A. A., Angeletti, R. H., & Chi, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090137 · Cited by 64

Cytoprotective Effect of Mangiferin on Benzo(a)pyrene‐Induced Lung Carcinogenesis in Swiss Albino Mice

Rajendran, P., Ganapathy, E., & Sakthisekaran, D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00254.x · Cited by 61

in vitro Modulation of P-glycoprotein, MRP-1 and BCRP Expression by Mangiferin in Doxorubicin-Treated MCF-7 Cells

Louisa, M., Soediro, T. M., & Suyatna, F. D. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.4.1639 · Cited by 61

Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols

Carpéné, C., Gómez‐Zorita, S., Deleruyelle, S., & Carpene, M. A. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140815124052 · Cited by 61

Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro

Zhang, B., Zhao, J. J., Li, S., Yang, L., Zeng, L.-L., Chen, Y., & Fang, J. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.165 · Cited by 60

Concise Synthesis of Chafurosides A and B

Furuta, T., Nakayama, M., Suzuki, H., Tajimi, H., Inai, M., Nukaya, H., Wakimoto, T., & Kan, T. (2009) · Organic Letters · doi:10.1021/ol900689m · Cited by 60

Untitled work

(2006) · PubMed · Cited by 60

Mangifera indica L: extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse

Pardo-Andreu, G. L., Paim, B. A., Castilho, R. F., Velho, J. A., Delgado, R., Vercesi, A. E., & Oliveira, H. C. F. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.03.005 · Cited by 58

Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Shoji, K., Tsubaki, M., Yamazoe, Y., Satou, T., Itoh, T., Kidera, Y., Tanimori, Y., Yanae, M., Matsuda, H., Taga, A., et al. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0316-8 · Cited by 57

Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics

Bhattacharyya, S., Ahmmed, S. M., Saha, B. P., & Mukherjee, P. K. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6422 · Cited by 56

Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential

Das, S., Rao, B. N., & Rao, B. S. S. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.06.002 · Cited by 51

Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators

Wang, H.-L., Li, C.-Y., Zhang, B., Liu, Y.-D., Lu, B.-M., Shi, Z., An, N., Zhao, L.-K., Zhang, J.-J., Bao, J.-K., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15059016 · Cited by 51

Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression

XIAO, J., LIU, L., ZHONG, Z., XIAO, C., & ZHANG, J. (2015) · Oncology Reports · doi:10.3892/or.2015.3919 · Cited by 51

Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract

Bock, C., Waldmann, K.-H., & Ternes, W. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.08.001 · Cited by 50

X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice

Han, J., Yi, J., Liang, F., Jiang, B., Xiao, Y., Gao, S., Yang, N., Hu, H., Xie, W.-F., & Chen, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.008 · Cited by 50

Effect of mangiferin on the development of periodontal disease: Involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling

Carvalho, R. R., Pellizzon, C. H., Justulin, L. A., Felisbino, S. L., Vilegas, W., Bruni, F. M., Lopes‐Ferreira, M., & Hiruma-Lima, C. A. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.041 · Cited by 50

Mangiferin Antagonizes Rotenone: Induced Apoptosis Through Attenuating Mitochondrial Dysfunction and Oxidative Stress in SK-N-SH Neuroblastoma Cells

Kavitha, M., Manivasagam, T., Essa, M. M., Tamilselvam, K., Selvakumar, G. P., Karthikeyan, S., Thenmozhi, J. A., & Subash, S. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1249-7 · Cited by 48

Inhibition of Matrix Metalloproteinase-1 Induced by Oxidative Stress in Human Keratinocytes by Mangiferin Isolated fromAnemarrhena asphodeloides

Chae, S., Piao, M. J., Kang, K. A., Zhang, R., Kim, K. C., Youn, U. J., Nam, K., Lee, J. H., & Hyun, J. W. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110465 · Cited by 47

Mangiferin inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-κB activity

Dilshara, M. G., Kang, C.-H., Choi, Y. H., & Kim, G.-Y. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.10.003 · Cited by 47

Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice

Sakthisekaran, D., Rajendran, P., Rengarajan, T., Nishigaki, I., & Ganapathy, E. (2014) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.137966 · Cited by 46

Mangiferin: A promising therapeutic agent for rheumatoid arthritis treatment

Łuczkiewicz, P., Kokotkiewicz, A., Dampc, A., & Łuczkiewicz, M. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.021 · Cited by 44

Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity

Nair, P. S., & Devi, C. S. S. (2006) · Toxicology · doi:10.1016/j.tox.2006.08.030 · Cited by 44

Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: Role of endogenous opioids, KATP-channels and adenosine

Lopes, S. C., da Silva, A. V. L., Arruda, B. R., Morais, T. C., Rios, J. B., Trevisan, M. T. S., Rao, V. S. N., & Santos, F. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.05.016 · Cited by 43

On-line purity monitoring in high-speed counter-current chromatography: Application of HSCCC-HPLC-DAD for the preparation of 5-HMF, neomangiferin and mangiferin from Anemarrhena asphodeloides Bunge

Zhou, T., Zhu, Z., Wang, C., Fan, G., Peng, J., Chai, Y., & Wu, Y. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.01.050 · Cited by 43

Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells

ZHAO, J., ZHANG, B., LI, S., ZENG, L., CHEN, Y., & FANG, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1696 · Cited by 43

Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride

Viswanadh, E. K., Rao, B. N., & Rao, B. S. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110361752 · Cited by 42

Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells

Peng, Z. G., Yao, Y. B., Yang, J., Tang, Y. L., & Huang, X. (2015) · Genetics and Molecular Research · doi:10.4238/2015.may.12.2 · Cited by 41

Temperature and solvent dependent NMR studies on mangiferin and complete NMR spectral assignments of its acyl and methyl derivatives

Faizi, S., Zikr‐ur‐Rehman, S., Ali, M. S., & Naz, A. (2006) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1854 · Cited by 40

Mangiferin, a dietary xanthone protects against mercury‐induced toxicity in HepG2 cells

Agarwala, S., Nageshwar Rao, B., Kaivalya, M., Bhuwania, R., & Rao, B. S. S. (2010) · Environmental Toxicology · doi:10.1002/tox.20620 · Cited by 39

[CML cell line K562 cell apoptosis induced by mangiferin].

Peng, Z., Luo, J., Xia, L.-H., Chen, Y., & Song, S.-J. (2004) · PubMed · Cited by 37

Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage

Jain, P. K., Kharya, M. D., & Gajbhiye, A. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.738685 · Cited by 36

Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats

Hou, J., Zheng, D., Zhong, G., & Hu, Y. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0090 · Cited by 36

Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects of the Smad and SOX9 Pathways

Huh, J., Koh, P. S., Seo, B.-K., Park, Y.-C., Baek, Y.-H., Lee, J.-D., & Park, D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916025 · Cited by 35

High‐performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine

Wang, H., Ye, G., Tang, Y., Zhu, H., Ma, R., Sun, Z.-L., & Huang, C. (2006) · Biomedical Chromatography · doi:10.1002/bmc.695 · Cited by 35

Antioxidant Activities of Three Dihydrochalcone Glucosides from Leaves of Lithocarpus pachyphyllus

Yang, W., Liu, J., Qin, X.-D., Wu, W.-L., & Chen, Z. (2004) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2004-7-805 · Cited by 33

The effects of mangiferin (Mangifera indica L) in doxorubicin-induced cardiotoxicity in rats

Arozal, W., Suyatna, F., Juniantito, V., Rosdiana, D., Amurugam, S., Aulia, R., Monayo, E., & Siswandi, R. (2014) · Drug Research · doi:10.1055/s-0034-1394457 · Cited by 32

Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells

Zhang, B., Zhao, J. J., Li, S., Linglan, Z., Chen, Y., & Fang, J. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.927890 · Cited by 31

Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression

Gupta, D., Radhakrishnan, M., Kurhe, Y., Devadoss, T., Prabhakar, V., & Kanade, P. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.89 · Cited by 30

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

Zhou, C., Li, G., Li, Y., Gong, L., Huang, Y., Shi, Z., Du, S., Li, Y., Wang, M., Yin, J., et al. (2014) · Molecular BioSystems · doi:10.1039/c4mb00421c · Cited by 29

Mangiferin aglycone attenuates radiation‐induced damage on human intestinal epithelial cells

Lei, J., Zhou, C., Hu, H., Hu, L., Zhao, M., Yang, Y., Chuai, Y., Jin, N., & Cai, J. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24138 · Cited by 28

Mangiferin ameliorates the intestinal inflammatory response and the impaired gastrointestinal motility in mouse model of postoperative ileus

Morais, T. C., Arruda, B. R., Magalhães, H. S., Trevisan, M. T. S., Viana, D. D. A., Rao, V. S. N., & Santos, F. A. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1095-4 · Cited by 26

Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats

Garrido‐Suárez, B. B., Garrido, G., Castro-Labrada, M., Merino, N., Valdés, O., Rodeiro, I., Hernández, I., Figueiredo, J. G., Ferreira, S. H., & Delgado, R. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.019 · Cited by 25

Mangiferin Regulates Interleukin-6 and Cystathionine-b-Synthase in Lipopolysaccharide-Induced Brain Injury

Fu, Y., Zhang, F., Zhang, L., Liu, H., Zhao, Z., Wen, X., Wu, J. H., Qi, D., Sun, Y., Du, Y., et al. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0039-8 · Cited by 25

Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol

Wilkinson, A. S., Taing, M., Pierson, J. T., Lin, C.-N., Dietzgen, R. G., Shaw, P. N., Gidley, M. J., Monteith, G. R., & Roberts‐Thomson, S. J. (2015) · Food & Function · doi:10.1039/c5fo00133a · Cited by 23

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

Vieira, A. B., Coelho, L. P., Insuela, D. B. R., Carvalho, V. F., dos Santos, M. H., Silva, P., & Martins, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071759 · Cited by 23

[The effect of mangiferin on telomerase activity and apoptosis in leukemic K562 cells].

Peng, C., Peng, Z., Yang, J., & Song, S.-J. (2007) · PubMed · Cited by 23

Mangiferin in Leaves of Three Thai Mango (Mangifera indica L.) Varieties

Jutiviboonsuk, A. (2010) · Isan Journal of Pharmaceutical Sciences, IJPS (Isan J Pharm Sci) · doi:10.14456/ijps.2010.28 · Cited by 23

In vitrostudies on mangiferin protection against cadmium-induced human renal endothelial damage and cell death via the MAP kinase and NF-κB pathways

Rajendran, P., Rengarajan, T., Nishigaki, Y., Palaniswami, R., & Nishigaki, I. (2015) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1019137 · Cited by 22

Biotransformation of a C-Glycosylflavone, Abrusin 2-O-.BETA.-D-Apioside, by Human Intestinal Bacteria.

Li, Y., Meselhy, M. R., Wang, L., Ma, C., Nakamura, N., & Hattori, M. (2000) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.48.1239 · Cited by 22

Untitled work

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Chemopreventive efficacy of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals

Rajendran, P., Ganapathy, E., Magesh, V., & Sakthisekaran, D. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.05.005 · Cited by 21

Determination of mangiferin in rat eyes and pharmacokinetic study in plasma after oral administration of mangiferin-hydroxypropyl-beta-cyclodextrin inclusion

Zhang, H., Hou, Y., Liu, Y., Yu, X., Li, B., & Cui, H. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0024 · Cited by 21

Crystalline Structure of Mangiferin, a C‐Glycosyl‐Substituted 9H‐Xanthen‐9‐one Isolated from the Stem Bark of Mangifera indica

Júnior, J. W. D. C., MORAES, L. R. D., dos Santos, M. H., da Silva, G. A., Brigagão, M. R. P. L., Ellena, J., & Doriguetto, A. C. (2008) · Helvetica Chimica Acta · doi:10.1002/hlca.200890005 · Cited by 20

Mangiferin Inhibits Passive Cutaneous Anaphylaxis Reaction and Pruritus in Mice

Lee, B., Trinh, H. T., Bae, E., Jung, K., & Kim, D. (2009) · Planta Medica · doi:10.1055/s-0029-1185773 · Cited by 18

Pharmacokinetic study of mangiferin in rat plasma and retina using high-performance liquid chromatography.

Hou, Y., Fan, S., Zhang, H., Gu, Y., Yu, X., & Li, B. (2010) · PubMed · Cited by 14

[Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice].

Hu, Q., Zhang, X., Wang, Y., & Kong, L. (2010) · PubMed · Cited by 13

In vitro protective effect of mangiferin against glycated protein-iron chelate induced toxicity in human umbilical vein endothelial cells

Venugopal, R., Sakthiseka, D., Rajkapoor, B., & Nishigaki, I. (2007) · Journal of Biological Sciences · doi:10.3923/jbs.2007.1227.1232 · Cited by 12

Yerba Mate (Ilex Paraguariensis A. St. Hil) and Risk Factors for Cardiovascular Diseases

Pontilho, P. D. M., Teixeira, A. M. N. D. C., BSc, C. Y., Luzia, L. A., Bastos, D. H. M., & Rondó, P. H. D. C. (2015) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-3-3-9 · Cited by 10

[Mangiferin protects rats against chronic bronchitis via regulating NF-kappaB (P65) and IkappaBalpha expression in mononuclear cells].

Zhi-quan, W., Li, Y., Deng, J., & Deng, J. (2014) · PubMed · Cited by 9

Effects of mangiferin on cytokines in rats with chronic bronchitis and expression of macrophage COX-2 in mice

Wang, Q. (2011) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm20111022 · Cited by 8

Effects of microRNA-139 on myocardial cell injury induced by oxidative stress.

Li, T., Liang, S., Zhang, Y., & Chen, Y. (2015) · PubMed Central · Cited by 8

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 611

Chemical Composition of Mango (Mangifera indica L.) Fruit: Nutritional and Phytochemical Compounds

Celis, M. E. M., Yahia, E. M., Bedoya, R. A., Landázuri, P., Loango, N., Osma, J. A., Restrepo, B., & Ospina, J. C. G. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01073 · Cited by 563

Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit

Lebaka, V. R., Wee, Y., Ye, W., & Korivi, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020741 · Cited by 439

Valorization of agro-industrial wastes for biorefinery process and circular bioeconomy: A critical review

Yaashikaa, P. R., Kumar, P. S., & Varjani, S. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126126 · Cited by 405

Mangiferin: A comprehensive review on its extraction, purification and uses in food systems

Castro-Muñoz, R., Cabezas, R., & Plata-Gryl, M. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103188 · Cited by 165

Mangiferin: An effective therapeutic agent against several disorders (Review)

Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139

In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin

Kaurav, M., Kanoujia, J., Gupta, M., Goyal, P., Pant, S., Rai, S., Sahu, K. K., Bhatt, P., & Ghai, R. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100445 · Cited by 28

Perspectives on the potential of Mangiferin as a nutraceutical: a review

Jamwal, D., Saini, P., Tomar, P. C., & Ghosh, A. (2022) · Nutrition & Food Science · doi:10.1108/nfs-01-2022-0013 · Cited by 2

MANGIFERIN FROM MANGIFERA INDICA LINN.: A PHARMACOLOGICAL STUDY

Biswas, M., & Mistry, J. (2020) · Journal of Advanced Scientific Research

Mangiferin and Cancer: Mechanisms of Action

Gold-Smith, F., Fernandez, A., & Bishop, K. (2016) · Nutrients · doi:10.3390/nu8070396 · Cited by 158