The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis
Open accessAbstract
Background: Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising candidates for the treatment of diabetic wound healing. The present study aimed to investigate the effect of exosomes derived from MSCs pretreated with pioglitazone (PGZ-Exos) on diabetic wound healing. Results: We isolated PGZ-Exos from the supernatants of pioglitazone-treated BMSCs and found that PGZ-Exos significantly promote the cell viability and proliferation of Human Umbilical Vein Vascular Endothelial Cells (HUVECs) injured by high glucose (HG). PGZ-Exos enhanced the biological functions of HUVECs, including migration, tube formation, wound repair and VEGF expression in vitro. In addition, PGZ-Exos promoted the protein expression of p-AKT, p-PI3K and p-eNOS and suppressed that of PTEN. LY294002 inhibited the biological function of HUVECs through inhibition of the PI3K/AKT/eNOS pathway. In vivo modeling in diabetic rat wounds showed that pioglitazone pretreatment enhanced the therapeutic efficacy of MSCs-derived exosomes and accelerated diabetic wound healing via enhanced angiogenesis. In addition, PGZ-Exos promoted collagen deposition, ECM remodeling and VEGF and CD31 expression, indicating adequate angiogenesis in diabetic wound healing. Conclusions: PGZ-Exos accelerated diabetic wound healing by promoting the angiogenic function of HUVECs through activation of the PI3K/AKT/eNOS pathway. This offers a promising novel cell-free therapy for treating diabetic wound healing. Graphic abstract:
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Cites
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Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
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Cited by
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 341
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Self-citationApplications of mesenchymal stem cell-exosome components in wound infection healing: new insights
Fakouri, A., Razavi, Z.-S., Mohammed, A. T., Hussein, A. H. A., Afkhami, H., & Hooshiar, M. H. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae021 · Cited by 69
Hu, H., Zhang, H., Bu, Z., Liu, Z., Lv, F., Pan, M., Huang, X., & Cheng, L. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s389471 · Cited by 69
Metadata
- Authors
- Hu, Y., Tao, R., Chen, L., Xiong, Y., Xue, H., Hu, L., Yan, C., Xie, X., Lin, Z., Panayi, A. C., Mi, B., & Liu, G.
- Venue
- Journal of Nanobiotechnology
- Published
- 2021-05-21
- Volume
- 19
- Issue
- 1
- Pages
- 150-150
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W3163388727
- Cited by
- 328
- References
- 59
- FWCI
- 19.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hu, Y., Tao, R., Chen, L., Xiong, Y., Xue, H., Hu, L., Yan, C., Xie, X., Lin, Z., Panayi, A. C., Mi, B., & Liu, G. (2021). Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-021-00894-5
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