Cited by 443Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementElectrospun Nanofibers in Biomedical Applications

Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing

Shiekh, Parvaiz A., Singh, Anamika, Kumar, Ashok·2020·Biomaterials

Abstract

Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds. Therefore, delivering oxygen, inducing angiogenesis, and management of oxidative stress and infection may provide newer and improved therapeutic avenues for better clinical outcomes in diabetic wound healing. Here, we report the development and evaluation of an exosome laden oxygen releasing antioxidant wound dressing OxOBand to promote wound closure and skin regeneration in diabetic wounds. OxOBand is composed of antioxidant polyurethane (PUAO), as highly porous cryogels with sustained oxygen releasing properties and supplemented with adipose-derived stem cells (ADSCs) exosomes. Exosomes engulfed by the cells enhanced the migration of human keratinocytes and fibroblasts and increased the survival of human neuroblastoma cells under hyperglycemic conditions. OxOBand facilitated faster wound closure, enhanced collagen deposition, faster re-epithelialization, increased neo-vascularization, and decreased oxidative stress within two weeks as compared to untreated diabetic control wounds. The dressing promoted the development of mature epithelial structures with hair follicles and epidermal morphology similar to that of healthy skin. In clinically challenging infected diabetic wounds, these dressings prevented infection and ulceration, improved wound healing with increased collagen deposition, and re-epithelialization. Altogether, OxOBand is a remarkably newer treatment strategy for enhanced diabetic wound healing and may lead to novel therapeutic interventions for the treatment of diabetic ulcers.

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Crossref · 10.1016/j.biomaterials.2020.120020

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  • Antioxidant wound dressing consisting of antioxidant polyurethane combined with ADSC exosomes could shorten diabetic wound healing time.

    “Furthermore, Shiekh et al. have shown that an antioxidant wound dressing, consisting of antioxidant polyurethane combined with ADSCs extracted exosomes, could shorten the diabetic wound healing time [105].”

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Authors
Shiekh, P. A., Singh, A., & Kumar, A.
Affiliations
Indian Institute of Technology Kanpur (IN)
Corresponding author
Kumar, Ashok
Venue
Biomaterials
Publisher
Elsevier BV
Published
2020-08
Volume
249
Pages
120020
ISSN
0142-9612 (ISSN-L)
OpenAlex
W3015385912
Cited by
443
References
53
Citations by year
2026: 53 · 2025: 75 · 2024: 82 · 2023: 97 · 2022: 82 · 2021: 40 · 2020: 14
FWCI
32.28
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Human Resource Development (2019/P612/SL)
  • Impacting Research Innovation and Technology (MHRD_6714)
  • Indian Institute of Technology Kanpur
  • Department of Science and Technology, Ministry of Science and Technology, India
  • Department of Biotechnology, Ministry of Science and Technology, India (DST/INT/SWD/P-11/2016, DBT/IN/SWEDEN/08/AK/2017-1, MHRD_IITK_006, SPARC/2018\u20132019/P612/SL)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
diabetic wound healing, infected diabetic wounds, exosomes, adipose-derived stem cells, angiogenesis, oxidative stress, re-epithelialization, collagen deposition, keratinocyte migration, fibroblast survival, skin regeneration, wound closure
MeSH terms
Anti-Bacterial Agents, Antioxidants, Bandages, Diabetes Mellitus, Humans, Oxygen, Wound Healing, Exosomes, Cryogels

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