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Cited by 36Biochemical effects in animalsMuscle metabolism and nutritionSports Performance and Training

Effects of β-alanine supplementation during a 5-week strength training program: A randomized, controlled study

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Maté-Muñoz, José Luis, Lougedo, Juan H., Garnacho-Castaño, Manuel V., Veiga-Herreros, Pablo, Lozano-Estevan, María del Carmen, García-Fernández, Pablo, de Jesús, Fernando, Guodemar-Pérez, Jesús +2 more·2018·Journal of the International Society of Sports Nutrition
DOI 10.1186/s12970-018-0224-0PMC PMC5918575
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Abstract

Background β-Alanine (BA) is a non-essential amino acid that has been shown to enhance exercise performance. The purpose of this investigation was to determine if BA supplementation improved the adaptive response to five weeks of a resistance training program.Methods Thirty healthy, strength-trained individuals were randomly assigned to the experimental groups placebo (PLA) or BA. Over 5 weeks of strength training, subjects in BA took 6.4 g/day of BA as 8 × 800 mg doses each at least 1.5 h apart. The training program consisted of 3 sessions per week in which three different leg exercises were conducted as a circuit (back squat, barbell step ups and loaded jumping lunges). The program started with 3 sets of 40 s of work per exercise and rest periods between sets of 120 s in the first week. This training volume was then gradually built up to 5 sets of 20 s work/60 s rest in the fifth week. The work load during the program was set by one of the authors according to the individual’s perceived effort the previous week. The variables measured were average velocity, peak velocity, average power, peak power, and load in kg in a back squat, incremental load, one-repetition maximum (1RM) test. In addition, during the rest period, jump ability (jump height and power) was assessed on a force platform. To compare data, a general linear model with repeated measures two-way analysis of variance was used.Results Significantly greater training improvements were observed in the BA group versus PLA group (p = 0.045) in the variables average power at 1RM (BA: 42.65%, 95% CI, 432.33, 522.52 VS. PLA: 21.07%, 95% CI, 384.77, 482.19) and average power at maximum power output (p = 0.037) (BA: 20.17%, 95% CI, 637.82, 751.90 VS. PLA; 10.74%, 95% CI, 628.31, 751.53). The pre- to post training average power gain produced at 1RM in BA could be explained by a greater maximal strength gain, or load lifted at 1RM (p = 0.014) (24 kg, 95% CI, 19.45, 28.41 VS. 16 kg, 95% CI, 10.58, 20.25) and in the number of sets executed (p = 0.025) in the incremental load test (BA: 2.79 sets, 95% CI, 2.08, 3.49 VS. PLA: 1.58 sets, 95% CI, 0.82, 2.34).Conclusions β-Alanine supplementation was effective at increasing power output when lifting loads equivalent to the individual’s maximal strength or when working at maximum power output. The improvement observed at 1RM was explained by a greater load lifted, or strength gain, in response to training in the participants who took this supplement.

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  • Muscle velocity and muscle power assessment require optimal neuromuscular conditions, and studies analyzing supplement effects on muscular velocity and power selected a maximum of two repetitions with a submaximal load, with recovery periods of 2−5 min.

    “Muscle velocity and muscle power assessment require optimal neuromuscular conditions and, as such, studies analyzing the effect of different supplements on muscular velocity and power selected a maximum of two repetitions with a submaximal load, with recovery periods of 2−5 min [117,118,119,120,121,122].”

    From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [120]

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Research works printed but not linked: 3

  1. [34]Lozano Estevan MC Martínez RC Lozano MC Córdoba D Córdoba M Cápsulas gelatinosas rígidas Manual de Tecnología Farmacéutica 2012 Elsevier Barcelona 343 353
  2. [43]Baechle TR Eaerle RW Wathen D Baechle TR Earle RW Resistance training, chapter 18 Essential of strength training and conditioning (NSCA) 2000 Champaign IL Human Kinetics 395 325
  3. [48]Maté-Muñoz JL Domínguez R Barba M Monroy AJ Ruiz-Solano P Garnacho-Castaño MV Cardiporrespiratory and metabolic responses to loaded half squat corresponding to the lactate threshold J Sport Sci Med 2015 14 648 656 PMC4541131 26336353

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Authors
Maté-Muñoz, J. L., Lougedo, J. H., Garnacho-Castaño, M. V., Veiga-Herreros, P., Lozano-Estevan, M. D. C., García-Fernández, P., de Jesús, F., Guodemar-Pérez, J., San Juan, A. F., & Domínguez, R.
Affiliations
  • Department of Physical Activity and Sport Sciences, Faculty of Health SciencesAlfonso X El Sabio University, Avda Universidad 1, Building C, 3rd floor, Office C-A15, Villanueva de la Cañada 28691 Madrid Spain
  • Department of Physical Activity and Sport Sciences, TecnoCampus, College of Health SciencesPompeu Fabra University Ernest Lluch, 32 (Porta Laietana) 08302 Mataró-Barcelona Spain
  • Universidad Alfonso X el Sabio (ES)
  • Department of Pharmacy, Faculty of Health SciencesAlfonso X El Sabio University, Avda Universidad 1, Building D, 3rd floor, Office D-348, Villanueva de la Cañada 28691 Madrid Spain
  • Department of Physiotherapy, Faculty of Health SciencesCamilo José Cela University, Urb Villafranca del Castillo, Calle Castillo de Alarcón, 49, Villanueva de la Cañada 28692 Madrid Spain
  • Department of Health and Human Performance. Faculty of Physical Activity and Sport SciencesPolytechnic University Social Building, 2nd floor, Office 205 Madrid Spain
ORCID
Venue
Journal of the International Society of Sports Nutrition
Publisher
Informa UK Limited
Published
2018-01-05
Volume
15
Issue
1
Pages
19-19
ISSN
1550-2783 (ISSN-L)
DOI
10.1186/s12970-018-0224-0
PMC
PMC5918575
OpenAlex
W2802703456
Cited by
36
References
55
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
beta-alanine supplementation, resistance training, one-repetition maximum, muscle power, muscle strength, exercise performance, amino acid supplementation, circuit training, back squat, jump performance, training effects, healthy adults, training duration, training mode
MeSH terms
Adolescent, Adult, Exercise Test, Humans, Male, beta-Alanine, Muscle, Skeletal, Dietary Supplements, Muscle Strength, Resistance Training, Young Adult, Sports Nutritional Physiological Phenomena

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