PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4

Bi, Wei; Bao, Keyao; Zhou, Xinqi; Deng, Yihui; Li, Xiaoting; Zhang, Jiawei; Lan, Xin; Zhao, Jiayi; Lu, Daxiang; Xu, Yezi; Cen, Yanmei; Cao, Rui; Xu, Mengyang; Zhong, Wenbin; Zhu, Lihong

doi:10.1186/s12974-023-02904-9

PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4

Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation in activated microglia. We aimed to determine whether regulating PSMC5 expression could i…