Cited by 41Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismNatural Products and Biological Research

Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial

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Cicero, Arrigo F.G., Fogacci, Federica, Rosticci, Martina, Parini, Angelo, Giovannini, Marina, Veronesi, Maddalena, D’Addato, Sergio, Borghi, Claudio·2017·Nutrition & Metabolism

Abstract

Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from Monascus purpureus (group 2), or both combined nutraceuticals (group 3). After 8 weeks of treatment, in group 1 no significant variation of lipid parameters has been detected. In group 2 a significant reduction (p < 0.001) of LDL-Cholesterol (−20.5% vs. baseline) and Apolipoprotein B (−14.4% vs. baseline) as it occurred in group 3 (LDL-Cholesterol vs. baseline: −27.0%, Apolipoprotein B vs. baseline: -19.0%) (P < 0.001). LDL-Cholesterol and Apolipoprotein B changes were significantly different comparing group 2 with group 1 (P < 0.05), and group 3 with group 1 (P < 0.05). LDL-Cholesterol change was also significantly higher in group 3 than in group 2 (P < 0.05). The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients. ClinicalTrial.gov ID: NCT02603276 , Registered 27/08/2015.

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Authors
Cicero, A. F. G., Fogacci, F., Rosticci, M., Parini, A., Giovannini, M., Veronesi, M., D’Addato, S., & Borghi, C.
Affiliations
University of Bologna (IT)
Corresponding author
Cicero, Arrigo F.G.
Venue
Nutrition & Metabolism
Published
2017-09-25
Volume
14
Issue
1
Pages
61-61
ISSN
1743-7075 (ISSN-L)
OpenAlex
W4250166675
Cited by
41
References
33
Citations by year
2025: 4 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 2
FWCI
5.88
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nutrition & Metabolism (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Università di Bologna (RFO 2015)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
Keywords
phytosterols, red yeast rice, Monascus purpureus, monacolins, hypercholesterolemia, LDL cholesterol, apolipoprotein B, lipid profile, dietary supplementation

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