Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial
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Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from Monascus purpureus (group 2), or both combined nutraceuticals (group 3). After 8 weeks of treatment, in group 1 no significant variation of lipid parameters has been detected. In group 2 a significant reduction (p < 0.001) of LDL-Cholesterol (−20.5% vs. baseline) and Apolipoprotein B (−14.4% vs. baseline) as it occurred in group 3 (LDL-Cholesterol vs. baseline: −27.0%, Apolipoprotein B vs. baseline: -19.0%) (P < 0.001). LDL-Cholesterol and Apolipoprotein B changes were significantly different comparing group 2 with group 1 (P < 0.05), and group 3 with group 1 (P < 0.05). LDL-Cholesterol change was also significantly higher in group 3 than in group 2 (P < 0.05). The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients. ClinicalTrial.gov ID: NCT02603276 , Registered 27/08/2015.
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The association of plant sterols/stanols with certain lipid-lowering ingredients strengthens cholesterol-lowering efficacy and adds TG-lowering effects.
“The association of plant sterols/stanols with certain lipid-lowering ingredients also demonstrated to strengthen cholesterol-lowering efficacy and add TG-lowering effects [96].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [96]
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- Authors
- Cicero, A. F. G., Fogacci, F., Rosticci, M., Parini, A., Giovannini, M., Veronesi, M., D’Addato, S., & Borghi, C.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Cicero, Arrigo F.G.
- ORCID
- Venue
- Nutrition & Metabolism
- Published
- 2017-09-25
- Volume
- 14
- Issue
- 1
- Pages
- 61-61
- ISSN
- 1743-7075 (ISSN-L)
- PMC
- PMC5613479
- OpenAlex
- W4250166675
- Cited by
- 41
- References
- 33
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 2
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-06-20)
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Nutrition & Metabolism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università di Bologna (RFO 2015)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- phytosterols, red yeast rice, Monascus purpureus, monacolins, hypercholesterolemia, LDL cholesterol, apolipoprotein B, lipid profile, dietary supplementation
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