The DOI matches its Crossref record; 186 of the 187 references it cites were found in a registry or an index.
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Open accessAbstract
Alzheimer’s disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival. In brain, Wnt/β-catenin signaling is not only crucial for neuronal survival and neurogenesis, but it plays important roles in regulating synaptic plasticity and blood-brain barrier integrity and function. Moreover, activation of Wnt/β-catenin signaling inhibits amyloid-β production and tau protein hyperphosphorylation in the brain. Critically, Wnt/β-catenin signaling is greatly suppressed in AD brain via multiple pathogenic mechanisms. As such, restoring Wnt/β-catenin signaling represents a unique opportunity for the rational design of novel AD therapies.
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“restoring Wnt/β-catenin signaling, which is greatly suppressed in AD brains, is a promising therapeutic strategy”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [14]
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“Wnt/β-catenin signaling is not only crucial for neuronal survival and neurogenesis but also plays important roles in regulating synaptic plasticity and blood–brain barrier integrity and function [14].”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [14]
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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519
Self-citationWnt signaling pathway: A comprehensive review
Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 379
Ramakrishna, K., Nalla, L. V., Dumala, N., Venkateswarlu, K., Viswanadh, M. K., Nalluri, B. N., Chakravarthy, G., Duguluri, S., Singh, P., Nand, S., et al. (2023) · Diseases · doi:10.3390/diseases11030089 · Cited by 206
Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease
Su, L., Li, R., Zhang, Z.-Q., Liu, J., Du, J., & Wei, H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101497 · Cited by 118
Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
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Metadata
- Authors
- Jia, L., Piña-Crespo, J., & Li, Y.
- Affiliations
- Mayo Clinic (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Li, Yonghe
- Venue
- Molecular Brain
- Published
- 2019-12
- Volume
- 12
- Issue
- 1
- Pages
- 104-104
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC6894260
- OpenAlex
- W2992486783
- Cited by
- 288
- References
- 187
- Citations by year
- 2026: 31 · 2025: 42 · 2024: 48 · 2023: 48 · 2022: 57 · 2021: 45 · 2020: 16
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Brain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Ed and Ethel Moore Alzheimer’s Disease Research Program Pilot Grant from the Florida Department of Health (9AZ09)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, Wnt/β-catenin signaling, therapeutic target, synaptic plasticity, blood-brain barrier, amyloid-beta production, tau hyperphosphorylation, neuronal survival, neurogenesis, synaptic loss
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Neuronal Plasticity, Neurogenesis, Molecular Targeted Therapy, Wnt Signaling Pathway
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