Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

The amyloid hypothesis of Alzheimer's disease at 25 years

Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Neuropathological alterations in Alzheimer disease

Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

Untitled work

Bloom (2014) · doi:10.1001/jamaneurol.2013.5847 · Cited by 2,194

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,129

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0297-y · Cited by 1,728

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577

Wnt signalling regulates adult hippocampal neurogenesis

Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,544

The complex world of WNT receptor signalling

Niehrs, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3470 · Cited by 1,538

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345

The GSK3 hypothesis of Alzheimer’s disease

Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191

Can we safely target the WNT pathway?

Kahn, M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4233 · Cited by 1,061

The role of brain vasculature in neurodegenerative disorders

Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0234-x · Cited by 998

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Koo, B.-K., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M., et al. (2012) · Nature · doi:10.1038/nature11308 · Cited by 980

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Hao, H.-X., Xie, Y., Zhang, Y., Charlat, O., Oster, E., Avello, M., Lei, H., Mickanin, C., Liu, D., Ruffner, H., et al. (2012) · Nature · doi:10.1038/nature11019 · Cited by 962

Functional morphology of the blood–brain barrier in health and disease

Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 860

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L.-L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.031 · Cited by 763

Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

Daneman, R., Agalliu, D., Zhou, L., Kuhnert, F., Kuo, C. J., & Barres, B. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805165106 · Cited by 753

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes & Development · doi:10.1101/gad.235473.113 · Cited by 656

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D. C., Moore, L., Nakashima, K., Asashima, M., & Gage, F. H. (2009) · Nature Neuroscience · doi:10.1038/nn.2360 · Cited by 648

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., & McMahon, A. P. (2008) · Science · doi:10.1126/science.1164594 · Cited by 641

Emerging roles of Wnts in the adult nervous system

Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 622

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

Efthymiou, A. G., & Goate, A. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0184-x · Cited by 562

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

Tiwari, S. K., Agarwal, S., Seth, B., Yadav, A., Nair, S., Bhatnagar, P., Karmakar, M., Kumari, M., Chauhan, L. K. S., Patel, D. K., et al. (2014) · ACS Nano · doi:10.1021/nn405077y · Cited by 558

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 515

Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis

Ryman, D. C., Acosta-Baena, N., Aisen, P. S., Bird, T., Danek, A., Fox, N. C., Goate, A., Frommelt, P., Ghetti, B., Langbaum, J. B. S., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000596 · Cited by 502

New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2

Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466

Physical exercise and cognitive performance in the elderly: Current perspectives.

Kirk-Sanchez, N., & McGough, E. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s39506 · Cited by 465

Therapeutic strategies for Alzheimer's disease in clinical trials

Godyń, J., Jończyk, J., Panek, D., & Malawska, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.07.006 · Cited by 462

GSK-3β, a pivotal kinase in Alzheimer disease

Llorens-Marítin, M., Jurado, J., Hernández, F., & Ávila, J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00046 · Cited by 451

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Rangaraju, S., Dammer, E. B., Raza, S. A., Rathakrishnan, P., Xiao, H., Gao, T., Duong, D. M., Pennington, M. W., Lah, J. J., Seyfried, N. T., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0254-8 · Cited by 430

TREM2 in Neurodegenerative Diseases

Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427

Sex and the development of Alzheimer's disease

Pike, C. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23827 · Cited by 416

The age factor in Alzheimer’s disease

Guerreiro, R., & Bras, J. (2015) · Genome Medicine · doi:10.1186/s13073-015-0232-5 · Cited by 415

Glial contributions to neurodegeneration in tauopathies

Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409

Reimagining Alzheimer's Disease—An Age-Based Hypothesis

Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 407

Update on Wnt signaling in bone cell biology and bone disease

Monroe, D. G., McGee‐Lawrence, M. E., Oursler, M. J., & Westendorf, J. J. (2011) · Gene · doi:10.1016/j.gene.2011.10.044 · Cited by 399

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 398

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09118-9 · Cited by 371

GSK3 and tau: Two convergence points in Alzheimer’s disease

Hernandez, F., Lucas, J. J., & Avila, J. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-129025 · Cited by 359

Canonical WNT signaling components in vascular development and barrier formation

Zhou, Y., Wang, Y., Tischfield, M. A., Williams, J., Smallwood, P. M., Rattner, A., Taketo, M. M., & Nathans, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76431 · Cited by 356

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav6221 · Cited by 327

Wnt signaling in the nervous system and in Alzheimer's disease

Inestrosa, N. C., & Varela-Nallar, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt051 · Cited by 324

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317

Novel insights into the development and maintenance of the blood-brain barrier

Engelhardt, B., & Liebner, S. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1811-2 · Cited by 313

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Bemiller, S. M., McCray, T. J., Allan, K., Formica, S. V., Xu, G., Wilson, G., Kokiko-Cochran, O. N., Crish, S. D., Lasagna-Reeves, C. A., Ransohoff, R. M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0216-6 · Cited by 299

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298

Blood–brain-barriers in aging and in Alzheimer’s disease

Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 285

Advances in developing novel therapeutic strategies for Alzheimer’s disease

Cao, J., Hou, J., Ping, J., & Cai, D. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0299-8 · Cited by 283

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0286-0 · Cited by 281

Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

Ataman, B., Ashley, J., Gorczyca, M. G., Ramachandran, P., Fouquet, W., Sigrist, S. J., & Budnik, V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.026 · Cited by 279

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau2291 · Cited by 271

Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease

Ferrari, G. V. D., Papassotiropoulos, A., Biechele, T. L., DeVriéze, F. W., Ávila, M. E., Major, M. B., Myers, A., Sáez, K. L., Henríquez, J. P., Zhao, A. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603523104 · Cited by 267

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

Vanhollebeke, B., Stone, O. A., Bostaille, N., Cho, C., Zhou, Y., Maquet, E., Gauquier, A., Cabochette, P., Fukuhara, S., Mochizuki, N., et al. (2015) · eLife · doi:10.7554/elife.06489 · Cited by 267

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

Zhou, Y., & Nathans, J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.018 · Cited by 265

Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study

Cramer, C., Haan, M. N., Galea, S., Langa, K. M., & Kalbfleisch, J. D. (2008) · Neurology · doi:10.1212/01.wnl.0000319647.15752.7b · Cited by 255

Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

Chang, J., Mancuso, M. R., Maier, C. M., Liang, X., Yuki, K., Yang, L., Kwong, J. W., Wang, J., Rao, V., Vallon, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4309 · Cited by 253

The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells

Esposito, G., Filippis, D. D., Carnuccio, R., Izzo, A. A., & Iuvone, T. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0025-1 · Cited by 252

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

Cho, C., Smallwood, P. M., & Nathans, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.031 · Cited by 251

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

Maqbool, M., Mobashir, M., & Hoda, N. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.018 · Cited by 235

Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin

Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 232

Effects of gender on nigral gene expression and parkinson disease

Cantuti‐Castelvetri, I., Keller-McGandy, C. E., Bouzou, B., Asteris, G., Clark, T. W., Frosch, M. P., & Standaert, D. G. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.02.009 · Cited by 229

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease

Liu, C.-C., Tsai, C.-W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.048 · Cited by 222

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

Nishimura, M., Yu, G., Lévesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., et al. (1999) · Nature Medicine · doi:10.1038/5526 · Cited by 221

WNT signaling in activated microglia is proinflammatory

Halleskog, C., Mulder, J., Dahlström, J., Mackie, K., Hortobágyi, T., Tanila, H., Puli, L., Färber, K., Harkany, T., & Schulte, G. (2010) · Glia · doi:10.1002/glia.21081 · Cited by 219

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Tran, K. A., Zhang, X., Predescu, D., Huang, X., Machado, R. F., Göthert, J. R., Malik, A. B., Valyi-Nagy, T., & Zhao, Y.-Y. (2016) · Circulation · doi:10.1161/circulationaha.115.015982 · Cited by 219

REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease

Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.023 · Cited by 216

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 212

Toward a Neurocentric View of Learning

Titley, H. K., Brunel, N., & Hansel, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.021 · Cited by 209

Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing

Soriano, S., Kang, D. E., Fu, M., Pestell, R. G., Chevallier, N., Zheng, H., & Koo, E. H. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.785 · Cited by 208

Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis

Jang, M., Bonaguidi, M. A., Kitabatake, Y., Sun, J., Song, J., Kang, E., Jun, H., Zhong, C., Su, Y., Guo, J. U., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.021 · Cited by 203

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

Karalay, Ö., Doberauer, K., Vadodaria, K. C., Knobloch, M., Berti, L., Miquelajauregui, A., Schwark, M., Jagasia, R., Taketo, M. M., Tarabykin, V., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013456108 · Cited by 201

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 199

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss

Purro, S. A., Dickins, E. M., & Salinas, P. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4562-11.2012 · Cited by 195

Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

Kang, D. E., Soriano, S., Frosch, M. P., Collins, T., Naruse, S., Sisodia, S. S., Leibowitz, G., Levine, F., & Koo, E. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04229.1999 · Cited by 194

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Cossetti, C., D’Adamo, P., Zardini, E., Andreoni, L., Ihekwaba, A., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.10.023 · Cited by 189

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Najm, R., Jones, E. A., & Huang, Y. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0324-6 · Cited by 183

Role of Dickkopf-1, an Antagonist of the Wnt/β-Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation

Zhang, Q.-G., Wang, R., Khan, M. B., Mahesh, V. B., & Brann, D. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2752-08.2008 · Cited by 183

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

Okamoto, M., Inoue, K., Iwamura, H., Terashima, K., Soya, H., Asashima, M., & Kuwabara, T. (2011) · The FASEB Journal · doi:10.1096/fj.11-184697 · Cited by 171

Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease

Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Prisco, A., Scali, C., Gianfriddo, M., Caricasole, A., Terstappen, G. C., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06566.x · Cited by 168

Fracture Risk in Patients with Alzheimer's Disease

Melton, L. J., Beard, C. M., Kokmen, E., Atkinson, E. J., & O’Fallon, W. M. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06859.x · Cited by 167

Osteoporosis or low bone mass at the femur neck or lumbar spine in older adults: United States, 2005-2008.

Looker, A. C., Borrud, L. G., Dawson-Hughes, B. F., Shepherd, J., & Wright, N. C. (2012) · PubMed · Cited by 165

Activation of β‐catenin signalling by GSK‐3 inhibition increases p‐glycoprotein expression in brain endothelial cells

Lim, J. C., Kania, K., Wijesuriya, H. C., Chawla, S., Sethi, J. K., Pułaski, Ł., Romero, I. A., Couraud, P. O., Weksler, B. B., Hladky, S. B., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05537.x · Cited by 163

Wnt7a Regulates Multiple Steps of Neurogenesis

Qu, Q., Sun, G., Murai, K., Ye, P., Li, W., Asuelime, G. E., Cheung, Y.-T., & Shi, Y. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00325-13 · Cited by 158

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

Hollands, C., Tobin, M. K., Hsu, M., Musaraca, K., Yu, T., Mishra, R., Kernie, S. G., & Lazarov, O. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0207-7 · Cited by 153

Specific inhibition of CBP/β-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation

Teo, J.-L., Ma, H., Nguyen, C., Lam, C., & Kahn, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504600102 · Cited by 153

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice

Stranahan, A. M., Lee, K., Becker, K. G., Zhang, Y., Maudsley, S. R., Martin, B., Cutler, R. G., & Mattson, M. P. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.016 · Cited by 153

Aging brain microenvironment decreases hippocampal neurogenesis through Wnt‐mediated survivin signaling

Miranda, C. J., Braun, L., Jiang, Y., Hester, M. E., Zhang, L., Riolo, M., Wang, H., Rao, M., Altura, R. A., & Kaspar, B. K. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00816.x · Cited by 153

In vivoActivation ofWntSignaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

Vargas, J., Fuenzalida, M., & Inestrosa, N. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0862-13.2014 · Cited by 149

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

Cerpa, W. F., Gambrill, A. C., Inestrosa, N. C., & Barría, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6311-10.2011 · Cited by 147

Wnt signaling in Alzheimer's disease: Up or down, that is the question

Boonen, R. A. C. M., van Tijn, P., & Živković, D. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.11.003 · Cited by 143

Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury

Main, B. S., Villapol, S., Sloley, S. S., Barton, D. J., Parsadanian, M., Iweka, C. A., Stefos, K. A., McCann, M. S., Washington, P. M., Rodriguez, O. C., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0249-5 · Cited by 142

Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB

Weihl, C. C., Ghadge, G. D., Kennedy, S. G., Hay, N., Miller, R. J., & Roos, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05360.1999 · Cited by 137

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

Marzo, A., Galli, S., Lopes, D. M., McLeod, F., Podpolny, M., Segovia‐Roldán, M., Ciani, L., Purro, S. A., Cacucci, F., Gibb, A. J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.024 · Cited by 137

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

Bettermann, K., Arnold, A. M., Williamson, J. D., Rapp, S. R., Sink, K. M., Toole, J. F., Carlson, M. C., Yaşar, S., DeKosky, S. T., & Burke, G. L. (2011) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2010.11.002 · Cited by 135

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Arenas, E. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju001 · Cited by 128

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1

Scali, C., Caraci, F., Gianfriddo, M., Diodato, E., Roncarati, R., Pollio, G., Gaviraghi, G., Copani, A., Nicoletti, F., Terstappen, G. C., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.016 · Cited by 128

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability

Vallon, M., Yuki, K., Nguyen, T. D., Chang, J., Yuan, J., Siepe, D. H., Miao, Y., Essler, M., Noda, M., García, K. C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.045 · Cited by 124

Impaired Wnt Signaling in the Prefrontal Cortex of Alzheimer’s Disease

Folke, J., Pakkenberg, B., & Brudek, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1103-z · Cited by 123

Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells

Zhang, X., Yin, W., Shi, X.-D., & Li, Y. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.02.009 · Cited by 116

Activation of the Wnt/β‐catenin pathway represses the transcription of the β‐amyloid precursor protein cleaving enzyme (BACE1) via binding of T‐cell factor‐4 to BACE1 promoter

Parr, C., Mirzaei, N., Christian, M., & Sastre, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-253211 · Cited by 114

Trolox and 17β-Estradiol Protect against Amyloid β-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway

Quintanilla, R. A., Muñoz, F. J., Metcalfe, M., Hitschfeld, M., Olivares, G. H., Godoy, J. A., & Inestrosa, N. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411936200 · Cited by 113

A role for APP in Wnt signalling links synapse loss with β-amyloid production

Elliott, C., Rojo, A. I., Ribé, E. M., Broadstock, M., Xia, W., Morin, P., Semënov, M. V., Baillie, G. S., Cuadrado, A., Al‐Shawi, R., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0231-6 · Cited by 111

Wnt proteins as modulators of synaptic plasticity

McLeod, F., & Salinas, P. C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.003 · Cited by 109

The impact of curcumin and its modified formulations on Alzheimer's disease

Farkhondeh, T., Samarghandian, S., Pourbagher‐Shahri, A. M., & Sedaghat, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28411 · Cited by 109

Canonical Wnt Signaling is Necessary for Object Recognition Memory Consolidation

Fortress, A. M., Schram, S., Tuscher, J. J., & Frick, K. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0659-13.2013 · Cited by 105

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103

APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner

Cui, S., Xiong, F., Hong, Y., Jung, J.-U., Li, X.-S., Liu, J.-Z., Yan, R., Mei, L., Feng, X., & Xiong, W.-C. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.299 · Cited by 101

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

Caruso, A., Motolese, M., Iacovelli, L., Caraci, F., Copani, A., Nicoletti, F., Terstappen, G. C., Gaviraghi, G., & Caricasole, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03867.x · Cited by 101

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Orellana, A. M., Vasconcelos, A. R., Leite, J. A., Lima, L. D. S., Andreotti, D. Z., Munhoz, C. D., Kawamoto, E. M., & Scavone, C. (2015) · Aging · doi:10.18632/aging.100853 · Cited by 99

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

Zhu, H., Zhang, W., Zhao, Y., Shu, X., Wang, W., Wang, D., Yang, Y., He, Z., Wang, X., & Ying, Y. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0295-z · Cited by 99

Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β‐catenin signaling pathway after spinal cord injury

Gao, K., Shen, Z., Yuan, Y., Han, D., Song, C., Guo, Y., & Mei, X. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13382 · Cited by 97

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis

Esteve, P., Sandonís, Á., Cardozo, M. J., Malapeira, J., Ibáñez, C., Crespo, I., Marcos, S., González-García, S., Toribio, M. L., Arribas, J., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2794 · Cited by 94

Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results

Merlo, S., Spampinato, S. F., & Sortino, M. A. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.059 · Cited by 94

Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice

Yang, M.-W., Wang, T.-H., Yan, P., Chu, L.-W., Yu, J., Gao, Z.-D., Li, Y.-Z., & Guo, B.-L. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.05.011 · Cited by 89

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

Cho, C., Smallwood, P. M., & Nathans, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.032 · Cited by 88

Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20‐ APP transgenic and wild‐type mice

Tapia‐Rojas, C., & Inestrosa, N. C. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14278 · Cited by 87

A population-based study on the association between dementia and hip fractures in 85-year olds

Johansson, C., & Skoog, I. G. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339676 · Cited by 84

Wnt signaling pathway in osteoporosis: Epigenetic regulation, interaction with other signaling pathways, and therapeutic promises

Amjadi‐Moheb, F., & Akhavan‐Niaki, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28207 · Cited by 84

Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment

Dobrowolski, R., Vick, P., Ploper, D., Gumper, I., Snitkin, H., Sabatini, D. D., & Robertis, E. M. D. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.026 · Cited by 83

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease

Wu, X., Piña-Crespo, J., Zhang, Y., Chen, X., & Xu, H. (2017) · Chinese Medical Journal · doi:10.4103/0366-6999.220313 · Cited by 81

Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors

McLeod, F., Bossio, A., Marzo, A., Ciani, L., Sibilla, S., Hannan, S. B., Wilson, G. A., Palomer, E., Smart, T. G., Gibb, A. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.119 · Cited by 80

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid‐β (Aβ)42 peptides

Tapia‐Rojas, C., Burgos, P. V., & Inestrosa, N. C. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13873 · Cited by 76

The effects of aging on the expression of Wnt pathway genes in mouse tissues

Hofmann, J. W., McBryan, T., Adams, P. D., & Sedivy, J. M. (2014) · AGE · doi:10.1007/s11357-014-9618-3 · Cited by 73

Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging

Zhu, Y., Demidov, O. N., Goh, A. M., Virshup, D. M., Lane, D. P., & Bulavin, D. V. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73015 · Cited by 73

Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling

Robin, N. C., Agoston, Z., Biechele, T. L., James, R. G., Berndt, J. D., & Moon, R. T. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.002 · Cited by 73

Frizzled-1 receptor regulates adult hippocampal neurogenesis

Mardones, M. D., Andaur, G. A., Varas‐Godoy, M., Henriquez, J. F., Salech, F., Behrens, M. I., Couve, A., Inestrosa, N. C., & Varela‐Nallar, L. (2016) · Molecular Brain · doi:10.1186/s13041-016-0209-3 · Cited by 72

The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases

García‐Velázquez, L., & Arias, C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.06.001 · Cited by 70

Chemical-Genetic Screen Identifies Riluzole as an Enhancer of Wnt/β-catenin Signaling in Melanoma

Biechele, T. L., Camp, N. D., Fass, D. M., Kulikauskas, R. M., Robin, N. C., White, B. D., Taraska, C. M., Moore, E. C., Muster, J., Karmacharya, R., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.08.012 · Cited by 69

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice

Bayod, S., Felice, P., Andrés‐Benito, P., Rosa, P., Camins, A., Pallàs, M., & Canudas, A.-M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.017 · Cited by 63

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism

Li, X., Shan, J., Chang, W., Kim, I., Bao, J., Lee, H., Zhang, X., Samuel, V. T., Shulman, G. I., Liu, D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205015109 · Cited by 63

Wnt pathway regulation by long-term moderate exercise in rat hippocampus

Bayod, S., Menella, I., Sanchez‐Roige, S., Lalanza, J. F., Escorihuela, R. M., Camins, A., Pallàs, M., & Canudas, A. M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.048 · Cited by 62

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer’s Disease

Dengler-Crish, C. M., Smith, M. A., & Wilson, G. N. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160658 · Cited by 61

Targeting psychologic stress signaling pathways in Alzheimer’s disease

Futch, H. S., Croft, C. L., Truong, V., Krause, E. G., & Golde, T. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0190-z · Cited by 61

Evidence of Wnt/β-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease

Dengler-Crish, C. M., Ball, H. C., Lin, L., Novak, K. M., & Cooper, L. N. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.021 · Cited by 58

Statins and Cognitive Decline in Older Adults with Normal Cognition or Mild Cognitive Impairment

Steenland, K., Zhao, L., Goldstein, F. C., & Levey, A. I. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12414 · Cited by 56

Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Berwick, D. C., Javaheri, B., Wetzel, A., Hopkinson, M., Nixon‐Abell, J., Grannò, S., Pitsillides, A. A., & Harvey, K. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0153-4 · Cited by 54

Simvastatin Promotes Osteogenic Differentiation of Mouse Embryonic Stem Cells Via Canonical Wnt/β-Catenin Signaling

Qiao, L., Kang, K. L., & Heo, J. S. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0107-6 · Cited by 54

The role of DKK1 in Alzheimer’s disease: A potential intervention point of brain damage prevention?

Ren, C., Gu, X.-X., Li, H.-H., Lei, S., Wang, Z., Wang, J., Yin, P., Zhang, C., Wang, F., & Liu, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.033 · Cited by 54

Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor

Buechler, J., & Salinas, P. C. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00038 · Cited by 53

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

Salašová, A., Yokota, C., Potěšil, D., Zdráhal, Z., Bryja, V., & Arenas, E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0193-9 · Cited by 52

High prevalence of dementia in women with osteoporosis

Amouzougan, A., Lafaie, L., Marotte, H., Dẻnariẻ, D., Collet, P., Pallot-Prades, B., & Thomas, T. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2016.08.002 · Cited by 51

Simvastatin Reverses High Glucose-Induced Apoptosis of Mesangial Cells via Modulation of Wnt Signaling Pathway

Lin, C.-L., Ho, C., Tung, C., Huang, W., Chang, P., Yang, J., & Wang, J.-Y. (2007) · American Journal of Nephrology · doi:10.1159/000111142 · Cited by 50

Lovastatin protects human neurons against Aβ-induced toxicity and causes activation of β-catenin–TCF/LEF signaling

Salins, P. B., Shawesh, S., He, Y., Dibrov, A., Kashour, T. S., Arthur, G., & Amara, F. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.045 · Cited by 50

Presenilin Affects Arm/β-Catenin Localization and Function in Drosophila

Noll, E., Medina, M., Hartley, D. M., Zhou, J., Perrimon, N., & Kosik, K. S. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9925 · Cited by 50

A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease

Alarcón, M. A., Medina, M. A., Hu, Q., Ávila, M. E., Bustos, B. I., Pérez‐Palma, E., Peralta, A. B., Salazar, P. L., Ugarte, G. D., Reyes, A. E., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.004 · Cited by 49

High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development

Sharma, K., Choi, S., Zhang, Y., Nieland, T. J. F., Long, S., Li, M., & Huganir, R. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.008 · Cited by 49

Effect of curcumin on memory impairment: A systematic review

Sanei, M., & Saberi-Demneh, A. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.016 · Cited by 48

A Screen for Mutations That Suppress the Phenotype of Drosophila armadillo, the β-Catenin Homolog

Cox, R. T., McEwen, D. G., Myster, D. L., Duronio, R. J., Loureiro, J., & Peifer, M. A. (2000) · Genetics · doi:10.1093/genetics/155.4.1725 · Cited by 43

Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation

Beaumont, V., Thompson, S. A., Choudhry, F., Nuthall, H. N., Glantschnig, H., Lipfert, L., David, G. R., Swain, C. J., McAllister, G., & Muñoz-Sanjuán, I. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.03.004 · Cited by 42

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1

Ciani, L., Marzo, A., Boyle, K. A., Stamatakou, E., Lopes, D. M., Anane, D., McLeod, F., Rosso, S. B., Gibb, A. J., & Salinas, P. C. (2015) · Nature Communications · doi:10.1038/ncomms9302 · Cited by 42

Corrigendum to “Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease” [Neurobiol. Dis. 41/2 (2011) 508–527]

L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Cossetti, C., D’Adamo, P., Zardini, E., Andreoni, L., Ihekwaba, A., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.015 · Cited by 40

WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers

Vargas, J., Ahumada, J., Arrázola, M. S., Fuenzalida, M., & Inestrosa, N. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.005 · Cited by 36

Wip1 knockout inhibits neurogenesis by affecting the Wnt/β-catenin signaling pathway in focal cerebral ischemia in mice

Qiu, C.-W., Liu, Z.-Y., Hou, K., Liu, S.-Y., Hu, Y.-X., Zhang, L., Zhang, F.-L., Lv, K.-Y., Kang, Q., Hu, W.-Y., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.011 · Cited by 36

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

Zoltowska, K. M., Maesako, M., Lushnikova, I., Takeda, S., Keller, L. J., Skibo, G., Hyman, B. T., & Berezovska, O. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0159-y · Cited by 36

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Iozzi, S., Remelli, R., Lelli, B., Diamanti, D., Pileri, S., Bracci, L., Roncarati, R., Caricasole, A., & Bernocco, S. (2012) · ISRN Molecular Biology · doi:10.5402/2012/823875 · Cited by 34

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

Lee, S. H., Lutz, D., Mossalam, M., Bolshakov, V. Y., Frotscher, M., & Shen, J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0189-5 · Cited by 34

Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis

Schneider, R., Koop, B. E., Schröter, F., Cline, J. E., Ingwersen, J., Berndt, C., Hartung, H., Aktaş, O., & Prozorovski, T. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0117-0 · Cited by 32

Amyloid precursor protein modulates β-catenin degradation

Chen, Y., & Bodles, A. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-29 · Cited by 31

Anti-aggregant tau mutant promotes neurogenesis

Joseph, M., Anglada‐Huguet, M., Paesler, K., Mandelkow�, E., & Mandelkow, E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0230-8 · Cited by 30

The role of β-catenin stability in mutant PS1-associated apoptosis

Weihl, C. C., Miller, R. J., & Roos, R. P. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00017 · Cited by 30

Shared mechanisms: osteoporosis and Alzheimer’s disease?

Crish, S. D., & Elefteriou, F. (2019) · Aging · doi:10.18632/aging.101828 · Cited by 28

Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons

Scott, E. L., Zhang, Q.-G., Han, D. K., Desai, B. N., & Brann, D. W. (2012) · Steroids · doi:10.1016/j.steroids.2012.11.004 · Cited by 27

Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies

Mpousis, S., Thysiadis, S., Avramidis, N., Katsamakas, S., Efthimiopoulos, S., & Sarli, V. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.11.024 · Cited by 26

The effect of statins on rate of cognitive decline in mild cognitive impairment

Smith, K. B., Kang, P. T., Sabbagh, M. N., & Initiative, A. D. N. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.01.001 · Cited by 24

Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer’s disease

Thysiadis, S., Katsamakas, S., Mpousis, S., Avramidis, N., Efthimiopoulos, S., & Sarli, V. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.06.018 · Cited by 23

The amyloid precursor protein binds to β-catenin and modulates its cellular distribution

Zhang, N., Parr, C., Birch, A. M., Goldfinger, M., & Sastre, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.08.044 · Cited by 17

Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes

Heymann, A. D., Ravona‐Springer, R., Moshier, E. L., Godbold, J., & Beeri, M. S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142571 · Cited by 10

Corrigendum to: Wnt pathway regulation by long-term moderate exercise in rat hippocampus [Brain Res. 1543 (2014) 38–48]

Bayod, S., Mennella, I., Sanchez‐Roige, S., Lalanza, J. F., Escorihuela, R. M., Camins, A., Pallàs, M., & Canudas, A. M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.12.001 · Cited by 6

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519

Wnt signaling pathway: A comprehensive review

Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 356

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Ramakrishna, K., Nalla, L. V., Dumala, N., Venkateswarlu, K., Viswanadh, M. K., Nalluri, B. N., Chakravarthy, G., Duguluri, S., Singh, P., Nand, S., et al. (2023) · Diseases · doi:10.3390/diseases11030089 · Cited by 204

Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease

Su, L., Li, R., Zhang, Z.-Q., Liu, J., Du, J., & Wei, H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101497 · Cited by 118

Primary cilia and ciliary signaling pathways in aging and age-related brain disorders

Ma, R., Kutchy, N. A., Chen, L., Meigs, D. D., & Hu, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105607 · Cited by 114

Therapeutic potential of targeting wingless-integrated/β-catenin/(Wnt/β-catenin) signaling pathway in Alzheimer's disease

Sakr, R., Mohamed, H., Abo–Elmatty, D. M., Wahba, N. S., & Wahba, A. S. (2023) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2023.189840.1206

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Zhao, X., Yang, R., Wu, J., & Sima, J. (2026) · Aging Research · doi:10.26599/agr.2026.9340068 · Cited by 1

Role of Wnt/β-Catenin pathway in the Pathophysiology of Alzheimer’s Disease

Atef, M. M., Moustafa, Y. M., Ahmed, A., & El-Sayed, N. M. (2023) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2023.234253.1241

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Nagu, P., Sharma, V., Behl, T., Pathan, A. K., & Mehta, V. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01940-5 · Cited by 28

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Ma, J., Liu, Y., Lu, D., & Sun, Q. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110754 · Cited by 5