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Cited by 1,273

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Open access
Tang, Rong, Xu, Jin, Zhang, Bo, Liu, Jiang, Liang, Chen, Hua, Jie, Meng, Qingcai, Yu, Xianjun, Shi, Si·2020·Journal of Hematology & Oncology
DOI 10.1186/s13045-020-00946-7
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Abstract

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to these agents. The induction of cell death mechanisms other than apoptosis has gradually emerged as a new cancer treatment strategy because most tumors harbor innate resistance to apoptosis. However, to date, the possibility of combining these two modalities has not been discussed systematically. Recently, a few studies revealed crosstalk between distinct cell death mechanisms and antitumor immunity. The induction of pyroptosis, ferroptosis, and necroptosis combined with ICIs showed synergistically enhanced antitumor activity, even in ICI-resistant tumors. Immunotherapy-activated CD8+ T cells are traditionally believed to induce tumor cell death via the following two main pathways: (i) perforin-granzyme and (ii) Fas-FasL. However, recent studies identified a new mechanism by which CD8+ T cells suppress tumor growth by inducing ferroptosis and pyroptosis, which provoked a review of the relationship between tumor cell death mechanisms and immune system activation. Hence, in this review, we summarize knowledge of the reciprocal interaction between antitumor immunity and distinct cell death mechanisms, particularly necroptosis, ferroptosis, and pyroptosis, which are the three potentially novel mechanisms of immunogenic cell death. Because most evidence is derived from studies using animal and cell models, we also reviewed related bioinformatics data available for human tissues in public databases, which partially confirmed the presence of interactions between tumor cell death and the activation of antitumor immunity.

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Metadata

Authors
Tang, R., Xu, J., Zhang, B., Liu, J., Liang, C., Hua, J., Meng, Q., Yu, X., & Shi, S.
Venue
Journal of Hematology & Oncology
Publisher
Springer Science and Business Media LLC
Published
2020-08-10
Volume
13
Issue
1
Pages
110-110
ISSN
1756-8722 (ISSN-L)
DOI
10.1186/s13045-020-00946-7
OpenAlex
W3048484045
Cited by
1,273
References
35
FWCI
99.25
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Ferroptosis, necroptosis, and pyroptosis in anticancer immunity. https://app.cochat.ai/papers/10.1186/s13045-020-00946-7
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Tang, R., Xu, J., Zhang, B., Liu, J., Liang, C., Hua, J., Meng, Q., Yu, X., & Shi, S. (2020). Ferroptosis, necroptosis, and pyroptosis in anticancer immunity. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-020-00946-7

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