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Cited by 156Ovarian function and disordersProbiotics and Fermented FoodsSelenium in Biological Systems

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

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Jamilian, Mehri, Mansury, Shirin, Bahmani, Fereshteh, Heidar, Zahra, Amirani, Elaheh, Asemi, Zatollah·2018·Journal of Ovarian Research
DOI 10.1186/s13048-018-0457-1PMC PMC6137747
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Abstract

BACKGROUND: The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. METHODS: CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention. RESULTS: Probiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β - 0.76; 95% CI, - 1.26, - 0.26; P = 0.003), general health questionnaire scores (β - 1.15; 95% CI, - 1.97, - 0.32; P = 0.007) and depression anxiety and stress scale scores (β - 1.49; 95% CI, - 2.59, - 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β - 0.26 ng/mL; 95% CI, - 0.51, - 0.02; P = 0.03), hirsutism (β - 0.43; 95% CI, - 0.74, - 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β - 0.58 mg/L; 95% CI, - 0.97, - 0.19; P = 0.004) and malondialdehyde (MDA) levels (β - 0.29 μmol/L; 95% CI, - 0.56, - 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P < 0.001) and total glutathione (GSH) levels (β + 26.78 μmol/L; 95% CI, + 4.33, + 49.23; P = 0.02) compared with the placebo. CONCLUSIONS: Overall, the co-administration of probiotic and selenium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, TAC, GSH and MDA levels. This study was prospectively registered in the Iranian website ( www.irct.ir ) for registration of clinical trials ( http://www.irct.ir : IRCT20170513033941N22). TRIAL REGISTRATION: IRCT20170513033941N22 .

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  • In a randomized controlled trial of 60 women with PCOS, probiotic and selenium co-supplementation for 12 weeks significantly improved testosterone levels, hirsutism, high-sensitivity CRP levels, and oxidative status measured by plasma malondialdehyde levels, and increased total antioxidant status and glutathione in plasma compared to placebo.

    “The authors found that the supplemented group significantly improved the testosterone levels, hirsutism, high-sensitivity CRP levels, and the oxidative status measured by plasma malondialdehyde levels. They also showed significant differences in increasing total antioxidant status and glutathione in plasma compared to the placebo group [39].”

    From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [39]

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Authors
Jamilian, M., Mansury, S., Bahmani, F., Heidar, Z., Amirani, E., & Asemi, Z.
Affiliations
  • Arak University of Medical Sciences (IR)
  • Kashan University of Medical Sciences (IR)
  • Shahid Beheshti University (IR)
Corresponding author
Asemi, Zatollah
ORCID
Venue
Journal of Ovarian Research
Publisher
Springer Science and Business Media LLC
Published
2018-09-14
Volume
11
Issue
1
Pages
80-80
ISSN
1757-2215 (ISSN-L)
DOI
10.1186/s13048-018-0457-1
PMC
PMC6137747
OpenAlex
W2889757990
Cited by
156
References
57
Citations by year
2026: 17 · 2025: 24 · 2024: 21 · 2023: 25 · 2022: 25 · 2021: 23 · 2020: 8 · 2019: 12
FWCI
11.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Ovarian Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Arak University of Medical Sciences
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords
polycystic ovary syndrome, probiotics, selenium supplementation, co-supplementation, mental health, depression, anxiety, testosterone, hirsutism, C-reactive protein, oxidative stress, malondialdehyde, lipid peroxidation, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, GSH, glutathione disulfide, GSH/GSSG ratio, oxidative stress index, inflammatory markers
MeSH terms
Adolescent, Adult, Double-Blind Method, Female, Humans, Inflammation, Mental Health, Polycystic Ovary Syndrome, Selenium, Biomarkers, Oxidative Stress, Probiotics, Young Adult

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