Anthropometric measures and serum estrogen metabolism in postmenopausal women: The women's health initiative observational study
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BACKGROUND: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study. METHODS: Fifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use. RESULTS: ) was positively associated with parent estrogens (multivariable adjusted GM 432 vs. 239 pmol/L for estrone, 74 vs. 46 pmol/L for estradiol; p-trend < 0.001 for both) and all of the 2-, 4-, and 16-pathway estrogen metabolites evaluated (all p-trend ≤ 0.02). After additional adjustment for estradiol, unconjugated methylated 2-catechols were inversely associated (e.g., 2-methoxyestrone multivariable GM 9.3 vs. 12.0 pmol/L; p-trend < 0.001). Among current MHT users, current BMI was not associated with parent estrogens but was inversely associated with methylated catechols (e.g., 2-methoxyestrone multivariable GM 216 vs. 280 pmol/L; p-trend = 0.008). Similar patterns of association were found with WHR; however, the associations were not independent of BMI. Height and BMI at age 18 years were not associated with postmenopausal estrogens/estrogen metabolite levels. CONCLUSIONS: Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.
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The lowest BMI and BF% resulted in low estrogen levels in menopausal female.
“The lowest BMI and BF% resulted in low estrogen levels in menopausal female (42).”
From The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity (2023) · cites this paper as [42]
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- Authors
- Oh, H., Coburn, S. B., Matthews, C. E., Falk, R. T., LeBlanc, E. S., Wactawski-Wende, J., Sampson, J., Pfeiffer, R. M., Brinton, L. A., Wentzensen, N., Anderson, G. L., Manson, J. E., Chen, C., Zaslavsky, O., Xu, X., & Trabert, B.
- Affiliations
- National Cancer Institute (US)
- Kaiser Permanente Center for Health Research (US)
- Fred Hutch Cancer Center (US)
- Brigham and Women's Hospital (US)
- University of Washington (US)
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Oh, Hannah
- ORCID
- Venue
- Breast Cancer Research
- Published
- 2017-03-11
- Volume
- 19
- Issue
- 1
- Pages
- 28-28
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- PMC
- PMC5346241
- OpenAlex
- W2592386792
- Cited by
- 36
- References
- 54
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Breast Cancer Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C)
- Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- estrogen metabolism, postmenopausal women, body mass index, waist-to-hip ratio, estrogen metabolites, catechol estrogens, 2-methoxyestrone, estradiol, estrone, hormone replacement therapy, breast cancer risk, anthropometry
- MeSH terms
- Adult, Aged, Aged, 80 and over, Body Weights and Measures, Breast Neoplasms, Chromatography, Liquid, Cross-Sectional Studies, Estrogens, Female, Humans, Middle Aged, Ovarian Neoplasms, Risk Factors, Case-Control Studies, Women's Health, Postmenopause, Tandem Mass Spectrometry, Metabolomics, Public Health Surveillance
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