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Cited by 288Cancer Risks and FactorsObesity, Physical Activity, DietEndometrial and Cervical Cancer Treatments

Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies

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Aune, D., Navarro Rosenblatt, D.A., Chan, D.S.M., Vingeliene, S., Abar, L., Vieira, A.R., Greenwood, D.C., Bandera, E.V. +1 more·2015·Annals of Oncology
DOI 10.1093/annonc/mdv142
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Abstract

Background Greater body mass index (BMI) has been convincingly related to increased endometrial cancer risk, however, whether adiposity earlier in life or abdominal fatness is an independent risk factor and whether weight gain or greater height increases the risk is not clear.Methods As part of the Continuous Update Project of the World Cancer Research Fund International, we conducted a systematic review and meta-analysis of prospective studies of the association between anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to February 2015. Summary relative risks (RRs) were calculated using a random-effects model.Results Thirty prospective studies of BMI and endometrial cancer risk with 22 320 cases among 6 445 402 participants were included. The summary RR for a 5-unit increment was 1.54 [95% confidence interval (CI) 1.47-1.61, I(2) = 81%]. Although the test for non-linearity was significant, Pnon-linearity < 0.0001, and the curve was steeper within the overweight and obese BMI ranges, there was evidence of increased risk even within the high normal BMI range. The summary RR was 1.45 (95% CI 1.28-1.64, I(2) = 76%) per 5 BMI units for BMI in young adulthood, 1.18 (95% CI 1.14-1.23, I(2) = 67%) per 5 kg increase of weight, and 1.16 (95% CI 1.12-1.20, I(2) = 51%) per 5 kg of weight gained between young adulthood and study baseline, 1.27 (95% CI 1.17-1.39, I(2) = 71%) per 10 cm increase in waist circumference, 1.21 (95% CI 1.13-1.29, I(2) = 0%) per 0.1-unit increment in waist-to-hip ratio and 1.30 (95% CI 1.19-1.41, I(2) = 0%) per 10-cm increase in hips circumference. The summary RR was 1.15 (95% CI 1.09-1.22, I(2) = 61%) for a 10-cm increase in height.Conclusions All measures of adiposity were associated with increased risk of endometrial cancer, and in addition increasing height was associated with increased risk.

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Authors
Aune, D., Navarro Rosenblatt, D. A., Chan, D. S. M., Vingeliene, S., Abar, L., Vieira, A. R., Greenwood, D. C., Bandera, E. V., & Norat, T.
Affiliations
  • Norwegian University of Science and Technology (NO)
  • Imperial College London (GB)
  • University of Leeds (GB)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Aune, D.
ORCID
Venue
Annals of Oncology
Publisher
Elsevier BV
Published
2015-08
Volume
26
Issue
8
Pages
1635-1648
ISSN
0923-7534 (ISSN-L)
DOI
10.1093/annonc/mdv142
OpenAlex
W2140383751
Cited by
288
References
93
Citations by year
2026: 27 · 2025: 28 · 2024: 33 · 2023: 32 · 2022: 30 · 2021: 29 · 2020: 23 · 2019: 14 · 2018: 21 · 2017: 24 · 2016: 20 · 2015: 7
FWCI
2.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
World Cancer Research Fund (2007/SP01)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
endometrial cancer, anthropometric factors, body mass index, obesity, abdominal fat, waist circumference, waist-to-hip ratio, hip circumference, weight gain, height, dose-response relationship, cancer risk
MeSH terms
Anthropometry, Female, Humans, Obesity, Risk Factors, Severity of Illness Index, Time Factors, Body Mass Index, Endometrial Neoplasms, Waist-Hip Ratio, Overweight, Waist Circumference, Obesity, Abdominal

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