The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver
Open accessAbstract
BACKGROUND: Geese were domesticated over 6,000 years ago, making them one of the first domesticated poultry. Geese are capable of rapid growth, disease resistance, and high liver lipid storage capacity, and can be easily fed coarse fodder. Here, we sequence and analyze the whole-genome sequence of an economically important goose breed in China and compare it with that of terrestrial bird species. RESULTS: A draft sequence of the whole-goose genome was obtained by shotgun sequencing, and 16,150 protein-coding genes were predicted. Comparative genomics indicate that significant differences occur between the goose genome and that of other terrestrial bird species, particularly regarding major histocompatibility complex, Myxovirus resistance, Retinoic acid-inducible gene I, and other genes related to disease resistance in geese. In addition, analysis of transcriptome data further reveals a potential molecular mechanism involved in the susceptibility of geese to fatty liver disease and its associated symptoms, including high levels of unsaturated fatty acids and low levels of cholesterol. The results of this study show that deletion of the goose lep gene might be the result of positive selection, thus allowing the liver to adopt energy storage mechanisms for long-distance migration. CONCLUSIONS: This is the first report describing the complete goose genome sequence and contributes to genomic resources available for studying aquatic birds. The findings in this study are useful not only for genetic breeding programs, but also for studying lipid metabolism disorders.
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The HGFv1 assembly is compatible with current poultry reference genomes.
“The HGFv1 assembly is compatible with current poultry reference genomes (Dalloul et al. 2010; Shapiro et al. 2013; Lu et al. 2015; ZhOu et al. 2018; Morris et al. 2020).”
From Genomic Analyses Unveil Helmeted Guinea Fowl (<i>Numida meleagris</i>) Domestication in West Africa (2021) · cites this paper as Lu et al. 2015
The Results and discussion sections on genome assembly and comparative genomic analysis describe a goose assembly and its comparisons with duck and chicken genomes; they do not assess HGFv1. Searches for HGFv1 and compatibility with poultry reference genomes found no passage addressing that assembly. (LLM, conf=0.76)
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Genomic Analyses Unveil Helmeted Guinea Fowl (<i>Numida meleagris</i>) Domestication in West Africa
Shen, Q.-K., Peng, M.-S., Adeola, A. C., Kui, L., Duan, S., Miao, Y.-W., Eltayeb, N. M., Lichoti, J. K., Otecko, N. O., Strillacci, M. G., et al. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab090 · Cited by 13 · see citing works
- Authors
- Lu, L., Chen, Y., Wang, Z., Li, X., Chen, W., Tao, Z., Shen, J., Tian, Y., Wang, D., Li, G., Chen, L., Chen, F., Fang, D., Yu, L., Sun, Y., Ma, Y., Li, J., & Wang, J.
- Affiliations
- ZheJiang Academy of Agricultural Sciences (CN)
- BGI Group (China) (CN)
- Corresponding author
- Li, Jinjun
- Wang, Jun
- ORCID
- Venue
- Genome biology
- Published
- 2015-05-06
- Volume
- 16
- Issue
- 1
- Pages
- 89-89
- ISSN
- 1465-6906 (ISSN-L)
- PMC
- PMC4419397
- OpenAlex
- W1488486557
- Cited by
- 137
- References
- 68
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 17 · 2023: 18 · 2022: 19 · 2021: 13 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Funders
- Earmarked Fund for China Agriculture Research System (CARS-43)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- hepatic steatosis, disease resistance genes, major histocompatibility complex, RIG-I, positive selection, unsaturated fatty acids, cholesterol, lipid metabolism, long-distance migration, waterbirds, comparative genomics, transcriptome
- MeSH terms
- Animals, Bird Diseases, Birds, China, Fatty Liver, Geese, Gene Expression Regulation, Liver, Male, Phylogeny, Sequence Alignment, Sequence Analysis, DNA, Evolution, Molecular, Genetic Predisposition to Disease, Comparative Genomic Hybridization, Genetic Association Studies, Transcriptome
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