Adherence and persistence rates of major antidiabetic medications: a review
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The objective of this paper was to review the adherence and persistence rates of major antidiabetic medication classes (i.e., metformin, sulfonylureas, sodium glucose cotransporter-2 inhibitors, dipeptidyl peptidase-4 inhibitors, insulin, glucagon-like peptide-1 receptor agonists, and thiazolidinediones) by summarizing the major findings of the studies published since 2017. In addition, we reported the potential causes for low adherence and persistence of antidiabetic medications. Based on the literature, the highest rate of adherence and persistence was consistently observed in metformin users. Second to metformin were sodium glucose cotransporter-2 inhibitors. Injectable therapies such as insulin and glucagon-like peptide-1 receptor agonists trailed low on the adherence and persistence rates. To the best of our knowledge, no studies published since the year 2017 analyzed the adherence and persistence of thiazolidinediones independently. The most frequently cited cause for low adherence and persistence was the severity of adverse events. Baseline characteristics (e.g., baseline HbA1c level), demographic information (e.g., age, gender, or ethnicity), and comorbidity profiles also had significant impacts on adherence and persistence in patients with type 2 diabetes mellitus.
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Retention in this therapy was high, exceeding persistence among available lifestyle programs and many pharmaceutical therapies.
“Retention in this therapy was high, exceeding persistence among available lifestyle programs [24,25] and many pharmaceutical therapies [26].”
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- Authors
- Lee, D. S. U., & Lee, H.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Lee, Howard
- Venue
- Diabetology & Metabolic Syndrome
- Published
- 2022-01-15
- Volume
- 14
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1758-5996 (ISSN-L)
- PMC
- PMC8761325
- OpenAlex
- W4206717797
- Cited by
- 72
- References
- 90
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 25 · 2023: 11 · 2022: 7
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (BK 21 four, 5120200513755)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- medication adherence, treatment persistence, antidiabetic drugs, type 2 diabetes, metformin, SGLT2 inhibitors, DPP-4 inhibitors, insulin, GLP-1 receptor agonists, thiazolidinediones, sulfonylureas, adverse drug reactions, HbA1c, comorbidities, demographic factors
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