Cited by 123Epigenetics and DNA MethylationSmoking Behavior and CessationBirth, Development, and Health

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

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Wiklund, Petri, Karhunen, Ville, Richmond, Rebecca C., Parmar, Priyanka, Rodriguez, Alina, De Silva, Maneka, Wielscher, Matthias, Rezwan, Faisal I. +7 more·2019·Clinical Epigenetics

Published version of a preprint

Abstract

BACKGROUND: Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. METHODS: We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring. RESULTS: ) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes. CONCLUSIONS: DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.

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Authors
Wiklund, P., Karhunen, V., Richmond, R. C., Parmar, P., Rodriguez, A., De Silva, M., Wielscher, M., Rezwan, F. I., Richardson, T. G., Veijola, J., Herzig, K.-H., Holloway, J. W., Relton, C. L., Sebert, S., & Järvelin, M.-R.
Affiliations
  • Imperial College London (GB)
  • University of Bristol (GB)
  • University of Oulu (FI)
  • University of Southampton (GB)
  • Oulu University Hospital (FI)
  • Poznan University of Medical Sciences (PL)
Corresponding author
Järvelin, Marjo-Riitta
Venue
Clinical Epigenetics
Published
2019-07-01
Volume
11
Issue
1
Pages
97-97
ISSN
  • 1868-7075 (ISSN-L)
  • 1868-7083
OpenAlex
W2951038195
Cited by
120
References
53
Citations by year
2026: 3 · 2025: 13 · 2024: 14 · 2023: 25 · 2022: 24 · 2021: 29 · 2020: 10 · 2019: 2
FWCI
5.38
Type
journal article
Language
en
Open access
Locations
  • Clinical Epigenetics (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion, cc-by)
  • Lincoln Repository (University of Lincoln) (acceptedVersion)
  • Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Explore Bristol Research (submittedVersion, cc-by)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
H2020 European Institute of Innovation and Technology (633595)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
smoking during pregnancy, prenatal smoking exposure, DNA methylation, epigenetic mediation, inflammatory bowel disease, schizophrenia, psychiatric morbidity, CpG sites, offspring outcomes, birth cohort studies
MeSH terms
Adolescent, Adult, Female, Humans, Longitudinal Studies, Middle Aged, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Schizophrenia, Smoking, Cohort Studies, Maternal Exposure, CpG Islands, DNA Methylation, Epigenesis, Genetic, GTP-Binding Protein gamma Subunits, Genome-Wide Association Study, Young Adult, Mendelian Randomization Analysis

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