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Stem cell models of Alzheimer’s disease: progress and challenges
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A major challenge to our understanding of the molecular mechanisms of Alzheimer's disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physiological expression levels of the gene(s) of interest. Induced pluripotent stem cell (iPSC) technology, together with advances in 2D and 3D neuronal differentiation, offers a unique opportunity to overcome this challenge and generate a limitless supply of human neurons for in vitro studies. iPSC-neuron models have been widely employed to model AD and we discuss in this review the progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is being made to overcome these. Finally, we highlight future directions for the use of iPSC-neurons in AD research and highlight the potential value of this technology to neurodegenerative research in the coming years.
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“For example, monolayer cultures of microglia have been widely used to study the basic functions of microglia, such as migration and phagocytosis.16”
From Acoustofluidic assembly of 3D neurospheroids to model Alzheimer's disease (2020) · cites this paper as [16]
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Metadata
- Authors
- Arber, C., Lovejoy, C., & Wray, S.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Wray, Selina
- Venue
- Alzheimer's Research & Therapy
- Published
- 2017-06-13
- Volume
- 9
- Issue
- 1
- Pages
- 42-42
- ISSN
- 1758-9193 (ISSN-L)
- PMC
- PMC5470327
- OpenAlex
- W2624768339
- Cited by
- 143
- References
- 157
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 14 · 2021: 19 · 2020: 26 · 2019: 26 · 2018: 19
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Alzheimer s Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Alzheimer’s Research UK
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- National Institute for Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, induced pluripotent stem cells, iPSC-derived neurons, patient-derived neurons, neuronal differentiation, in vitro disease model, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Cells, Cultured, Disease Models, Animal, Humans, Organoids, Tissue Engineering, Induced Pluripotent Stem Cells, Neural Stem Cells, Batch Cell Culture Techniques
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