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The Links between Cardiovascular Diseases and Alzheimer's Disease

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Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor

Garcia, G., Pinto, S., Cunha, M., Fernandes, A., Koistinaho, J., & Brites, D. (2021) · Cells · doi:10.3390/cells10092424 · Cited by 39 · see citing works

A new generation of AD biomarkers: 2019 to 2021

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Strategies for modeling aging and age-related diseases

Jothi, D., & Kulka, L. A. M. (2024) · npj Aging · doi:10.1038/s41514-024-00161-5 · Cited by 36 · see citing works

Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

García‐León, J. A., Cáceres-Palomo, L., Sánchez‐Mejías, E., Mejias‐Ortega, M., Nuñez‐Diaz, C., Fernandez-Valenzuela, J. J., Sanchez-Varo, R. M., Dávila, J. C., Vitórica, J., & Gutiérrez, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186867 · Cited by 35 · see citing works

Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research

Matuszyk, M. M., Garwood, C. J., Ferraiuolo, L., Simpson, J. E., Staniforth, R. A., & Wharton, S. B. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15538 · Cited by 35 · see citing works

High-Throughput Single-Molecule Surface-Enhanced Raman Spectroscopic Profiling of Single-Amino Acid Substitutions in Peptides by a Gold Plasmonic Nanopore

Li, W., Guo, L., Ding, X., Ding, Y., Ji, L., Xia, X., & Wang, K. (2024) · ACS Nano · doi:10.1021/acsnano.4c04775 · Cited by 34 · see citing works

Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons

Şatır, T. M., Nazir, F. H., Vizlin‐Hodzic, D., Hardselius, E., Blennow, K., Wray, S., Zetterberg, H., Agholme, L., & Bergström, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-57516-7 · Cited by 32 · see citing works

Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity

Saglam‐Metiner, P., Yıldırım, E., Dincer, C., Başak, O., & Yeşil-Çeliktaş, Ö. (2024) · Microchimica Acta · doi:10.1007/s00604-023-06165-4 · Cited by 36 · see citing works

Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Tournissac, M., Vu, T.-M., Vrabic, N., Hozer, C., Tremblay, C., Mélançon, K., Planel, E., Pifferi, F., & Calon, F. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00842-3 · Cited by 33 · see citing works

Cerebral microvascular endothelial glycocalyx damage, its implications on the blood–brain barrier and a possible contributor to cognitive impairment

Stoddart, P., Satchell, S. C., & Ramnath, R. D. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147804 · Cited by 31 · see citing works

The annotation of <i>GBA1</i> has been concealed by its protein-coding pseudogene <i>GBAP1</i>

Gustavsson, E. K., Sethi, S., Gao, Y., Brenton, J. W., García-Ruiz, S., Zhang, D., Garza, R., Reynolds, R. H., Evans, J. R., Chen, Z., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk1296 · Cited by 30 · see citing works

Advances in Central Nervous System Organoids: A Focus on Organoid-Based Models for Motor Neuron Disease

de Sá, R. V., Luna, M. C., & Pasterkamp, R. J. (2021) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0337 · Cited by 30 · see citing works

Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype

O’Connor, A., Pannee, J., Poole, T., Arber, C., Portelius, E., Swift, I. J., Heslegrave, A., Abel, E., Willumsen, N., Rice, H., et al. (2021) · Brain · doi:10.1093/brain/awab166 · Cited by 29 · see citing works

Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.

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Amyloid-β1–43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations

Perrone, F., Bjerke, M., Hens, E., Sieben, A., Timmers, M., Roeck, A. D., Vandenberghe, R. R., Sleegers, K., Martin, J., Deyn, P. P. D., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00676-5 · Cited by 28 · see citing works

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

Trujillo‐Estrada, L., Sánchez‐Mejías, E., Sanchez-Varo, R. M., García‐León, J. A., Nuñez‐Diaz, C., Dávila, J. C., Vitórica, J., LaFerla, F. M., Moreno‐González, I., Gutiérrez, A., et al. (2021) · The Neuroscientist · doi:10.1177/10738584211001753 · Cited by 28 · see citing works

Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons

Xie, J., Wu, S., Szadowski, H., Min, S., Yang, Y., Bowman, A. B., Rochet, J., Freeman, J. L., & Yuan, C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105023 · Cited by 27 · see citing works

The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer’s Disease

Bendtsen, K. M., & Hall, V. J. (2023) · Cells · doi:10.3390/cells12030420 · Cited by 27 · see citing works

Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer’s disease

Willumsen, N., Poole, T., Nicholas, J. M., Fox, N. C., Ryan, N. S., & Lashley, T. (2021) · Brain Pathology · doi:10.1111/bpa.13009 · Cited by 25 · see citing works

Onset of Preclinical Alzheimer Disease in Monozygotic Twins

Konijnenberg, E., Tomassen, J., den Braber, A., ten Kate, M., Yaqub, M. M., Mulder, S. D., Nivard, M. G., Vanderstichele, H., Lammertsma, A. A., Teunissen, C. E., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26048 · Cited by 25 · see citing works

3D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer’s disease using a smart bioink

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3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease

Lomoio, S., Pandey, R. S., Rouleau, N., Menicacci, B., Kim, W., Cantley, W. L., Haydon, P. G., Bennett, D. A., Young-Pearse, T. L., Carter, G. W., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02147-3 · Cited by 25 · see citing works

The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling

Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24 · see citing works

Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 24 · see citing works

Amyloid β production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Fourrière, L., & Gleeson, P. A. (2021) · Traffic · doi:10.1111/tra.12808 · Cited by 22 · see citing works

Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons

Mallach, A., Gobom, J., Arber, C., Piers, T. M., Hardy, J., Wray, S., Zetterberg, H., & Pocock, J. M. (2021) · Cells · doi:10.3390/cells10112866 · Cited by 18 · see citing works

Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer’s Disease Pathology, Constitute a Potential Object for Early Diagnosis

López-Toledo, G., Silva‐Lucero, M., Herrera‐Díaz, J., García, D.-E., Arias‐Montaño, J., & Cárdenas‐Aguayo, M. D. C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.921573 · Cited by 19 · see citing works

Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases

Haniff, Z. R., Bocharova, M., Mantingh, T., Rucker, J., Velayudhan, L., Taylor, D. M., Young, A. H., Aarsland, D., Vernon, A. C., & Thuret, S. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108641 · Cited by 21 · see citing works

Neurons derived from individual early Alzheimer’s disease patients reflect their clinical vulnerability

Ng, B., Rowland, H. A., Wei, T., Arunasalam, K., Hayes, E. M., Koychev, I., Hedegaard, A., Ribe, E. M., Chan, D., Chessell, T., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac267 · Cited by 18 · see citing works

Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation

Elsworthy, R. J., King, M. C., Grainger, A. I., Fisher, E., Crowe, J. A., Alqattan, S., Ludlam, A., Hill, E. J., & Aldred, S. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103631 · Cited by 19 · see citing works

Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout.

Arber, C., Villegas-Llerena, C., Toombs, J., Pocock, J. M., Ryan, N. S., Fox, N. C., Zetterberg, H., Hardy, J., & Wray, S. (2019) · Brain Communications · doi:10.1093/braincomms/fcz024 · Cited by 19 · see citing works

Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer’s disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and plasma

Michno, W., Blennow, K., Zetterberg, H., & Brinkmalm, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15466 · Cited by 18 · see citing works

Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies

Jiang, Y., & MacNeil, L. T. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00664-x · Cited by 20 · see citing works

An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer’s Disease

Vidal, C., & Li, Z. (2021) · Cells · doi:10.3390/cells10030546 · Cited by 19 · see citing works

Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Supakul, S., Murakami, R., Oyama, C., Shindo, T., Hatakeyama, Y., Itsuno, M., Bannai, H., Shibata, S., Maeda, S., & Okano, H. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-023-00310-5 · Cited by 18 · see citing works

Alzheimer’s Disease: Current Perspectives and Advances in Physiological Modeling

Boder, E. J., & Banerjee, I. A. (2021) · Bioengineering · doi:10.3390/bioengineering8120211 · Cited by 18 · see citing works

The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis

Guthertz, N., van der Kant, R., Martinez, R. M., Xu, Y., Trinh, C. H., Iorga, B. I., Rousseau, F., Schymkowitz, J. W. H., Brockwell, D. J., & Radford, S. E. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200468119 · Cited by 17 · see citing works

Dielectric Constant and Conductivity of Blood Plasma: Possible Novel Biomarkers for Alzheimer’s Disease

Dallé, E., Mabandla, M. V., & Daniels, W. M. U. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5756382 · Cited by 17 · see citing works

Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge

Fertan, E., Hung, C., Danial, J. S. H., Lam, J. Y. L., Preman, P., Albertini, G., English, E. A., Böken, D., Livesey, F. J., Strooper, B. D., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae454 · Cited by 16 · see citing works

Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity

Wu, Z., Bai, L., Tu, R., Zhang, L., Ba, Y., Zhang, H., Li, X., Cheng, X., Li, W., & Huang, H. (2020) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2020.103350 · Cited by 15 · see citing works

The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons

Elsworthy, R. J., Crowe, J. A., King, M. C., Dunleavy, C., Fisher, E., Ludlam, A., Parri, H. R., Hill, E. J., & Aldred, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02050-5 · Cited by 14 · see citing works

Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer’s disease iPSC-derived neurons and mice

Cusulin, C., Wells, I., Badillo, S., Duran-Pacheco, G. C., Baumann, K., & Patsch, C. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103392 · Cited by 13 · see citing works

Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia

Arber, C., Alatza, A., Leckey, C. A., Paterson, R. W., Zetterberg, H., & Wray, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15315 · Cited by 12 · see citing works

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

Arber, C., Belder, C. R. S., Tomczuk, F., Gabriele, R. M. C., Buhidma, Y., Farrell, C., O’Connor, A., Rice, H., Lashley, T., Fox, N. C., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13904 · Cited by 12 · see citing works

Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia

McInvale, J. J., Canoll, P., & Hargus, G. (2024) · Brain Pathology · doi:10.1111/bpa.13231 · Cited by 11 · see citing works

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPP α Release from PSEN1 Mutant iPSC-Derived Neurons

Giudice, M. L., Mihalik, B., Turi, Z., Dinnyés, A., & Kobolák, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190602 · Cited by 11 · see citing works

Hippocampal Neurogenesis in Alzheimer’s Disease: Multimodal Therapeutics and the Neurogenic Impairment Index Framework

Ma, L., Wei, Q., Jiang, M., Wu, Y., Liu, X., Yang, Q., Bai, Z., & Yang, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136105 · Cited by 10 · see citing works

Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models

Hasan, M. F., & Trushina, E. V. (2022) · Brain Sciences · doi:10.3390/brainsci12050552 · Cited by 10 · see citing works

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

Willumsen, N., Arber, C., Lovejoy, C. E. J., Toombs, J., Alatza, A., Weston, P. S. J., Chávez‐Gutiérrez, L., Hardy, J., Zetterberg, H., Fox, N. C., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac321 · Cited by 10 · see citing works

Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases

Ishihara, K., Takata, K., & Mizutani, K. (2023) · Life · doi:10.3390/life13010221 · Cited by 10 · see citing works

Alzheimer's disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasound

Chaves, J. C. S., Wasielewska, J. M., Cuní‐López, C., Rantanen, L. M., Lee, S., Koıstınaho, J., White, A. R., & Oikari, L. E. (2023) · Neurotherapeutics · doi:10.1016/j.neurot.2023.10.009 · Cited by 10 · see citing works

Research on Alzheimer's Disease (AD) Involving the Use of In vivo and In vitro Models and Mechanisms

Sinha, S., Wal, P., Prakash Goudanavar, S. O. P., Divya, S., Kimothi, V., Jyothi, D., Sharma, M. C., & Wal, A. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249293642240522054929 · Cited by 8 · see citing works

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Labra, S. R., Compher, J., Prabhavalkar, A., Almaraz, M., Kwong, C. C., Baal, C., Talantova, M. V., Dolatabadi, N., Piña‐Sanz, J., Wang, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.202514783 · Cited by 8 · see citing works

GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model

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Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

Lü, W., Shue, F., Kurti, A., Jeevaratnam, S., Macyczko, J. R., Roy, B., Izhar, T., Wang, N., Bu, G., Kanekiyo, T., et al. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.10.005 · Cited by 8 · see citing works

Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids

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Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia

Arber, C., Casey, J. M., Crawford, S., Rambarack, N., Yaman, Ü., Wiethoff, S., Augustin, E., Piers, T. M., Price, M., Rostagno, A. A., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02820-z · Cited by 8 · see citing works

Organelle perturbation in Alzheimer’s disease: do intracellular amyloid-ß and the fragmented Golgi mediate early intracellular neurotoxicity?

Fourrière, L., & Gleeson, P. A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1550211 · Cited by 6 · see citing works

Small extracellular vesicle‐based human melanocyte and melanoma signature

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A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report

Wan, K., Ma, Z.-J., Zhou, X., Zhang, Y., Yu, X., You, M., Huang, C., Zhang, W., & Sun, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.710075 · Cited by 6 · see citing works

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

Ziff, O. J., Jolly, S., Casey, J. M., Granat, L., Samra, S., Setó‐Salvia, N., Alatza, A., Phadke, L., Galet, B., Ravassard, P., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00864-7 · Cited by 9 · see citing works

Stable isotope labelling kinetics of neurofilament light

Leckey, C. A., Giovannucci, T. A., Coulton, J. B., He, Y., Sato, C., Ghoshal, N., Vignarajah, T., Jaunmuktane, Z., Barthélemy, N. R., Zetterberg, H., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf468 · Cited by 5 · see citing works

The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention?

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The role of d-block metal ions in neurodegenerative diseases

Posadas, Y., López-Guerrero, V. E., Arcos‐López, T., Sayler, R. I., Sánchez‐López, C., Segovia, J., Perez‐Cruz, C., & Quintanar, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823144-9.00115-1 · Cited by 5 · see citing works

Modeling Cellular Crosstalk of Neuroinflammation Axis by Tri-cultures of iPSC-Derived Human Microglia, Astrocytes, and Neurons

Connolly, K., Lehoux, M., Assetta, B., & Huang, Y. A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3287-1_7 · Cited by 5 · see citing works

The latest perspectives of small molecules FMS kinase inhibitors

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A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review

Gao, Y., Schedin‐Weiss, S., & Tjernberg, L. O. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00014 · Cited by 5 · see citing works

Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease

Xu, G. M., Fromholt, S., & Borchelt, D. (2022) · Biomolecules · doi:10.3390/biom12070886 · Cited by 5 · see citing works

Altered metabolic function induced by Aβ‐oligomers and PSEN1 mutations in iPSC ‐derived astrocytes

Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M. C., Ludlam, A., Tarczyluk, M. A., Allen, S., Prosser, S., Chen, R., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16267 · Cited by 4 · see citing works

Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Ellingford, R. A., Harris, S., Kehring, M., Rajani, R. M., Lam, F. K. W., Graykowski, D. R., Böken, D., Welikovitch, L. A., Khasnavis, A., Laban, R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.027 · Cited by 6 · see citing works

Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1

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O1‐03‐04: CORTICAL NEURONS AND CEREBRAL ORGANOIDS FROM APP AND PSEN1 MUTATION CARRIERS REVEAL MUTATION‐SPECIFIC EFFECTS ON Aβ PRODUCTION

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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

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O1–01–05: Human iPSC‐derived neurons reveal novel effects of the APP London mutation and show cell fate‐specific Alzheimer's disease relevant phenotypes

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

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The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue

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