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Cited by 555Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesInfectious Encephalopathies and Encephalitis

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Open access
Heneka, Michael T., Golenbock, Douglas, Latz, Eicke, Morgan, Dave, Brown, Robert·2020·Alzheimer's Research & Therapy
DOI 10.1186/s13195-020-00640-3PMC PMC7271826
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Abstract

Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.

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Metadata

Authors
Heneka, M. T., Golenbock, D., Latz, E., Morgan, D., & Brown, R.
Affiliations
  • University of Bonn (DE)
  • German Center for Neurodegenerative Diseases (DE)
  • University of Massachusetts Chan Medical School (US)
Corresponding author
Heneka, Michael T.
ORCID
Venue
Alzheimer's Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2020-06-04
Volume
12
Issue
1
Pages
69-69
ISSN
1758-9193 (ISSN-L)
DOI
10.1186/s13195-020-00640-3
PMC
PMC7271826
OpenAlex
W3032981909
Cited by
555
References
27
Citations by year
2026: 18 · 2025: 36 · 2024: 74 · 2023: 72 · 2022: 165 · 2021: 137 · 2020: 52
FWCI
46.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion, cc-by)
  • Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DZNE Pub (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Institute on Aging (R01AG059752)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords
COVID-19 pandemic, SARS-CoV-2, neurological complications, cognitive decline, long-term effects, neuroinflammation, inflammatory cytokines, neurodegenerative diseases, post-COVID cognitive impairment, mechanical ventilation
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Brain, Humans, Pneumonia, Viral, Time Factors, Coronavirus Infections, Neurodegenerative Diseases, Pandemics

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