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Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
Open accessAbstract
Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not yet been fully explained. OA is characterized by destruction of cartilage and loss of extracellular matrix (ECM). It is generally agreed that there is an association between pro-inflammatory cytokines and the development of OA. There is increased expression of matrix metalloproteinase (MMP) and “a disintegrin and metalloproteinase with thrombospondin motifs” (ADAMTS). Mesenchymal stem cells (MSCs) have been explored as a new treatment for OA during the last decade. It has been suggested that paracrine secretion of trophic factors, in which exosomes have a crucial role, contributes to the mechanism of MSC-based treatment of OA. The paracrine secretion of exosomes may play a role in the repair of joint tissue as well as MSC-based treatments for other disorders. Exosomes isolated from various stem cells may contribute to tissue regeneration in the heart, limbs, skin, and other tissues. Recent studies have indicated that exosomes (or similar particles) derived from MSCs may suppress OA development. Herein, for first time, we summarize the recent findings of studies on various exosomes derived from MSCs and their effectiveness in the treatment of OA. Moreover, we highlight the likely mechanisms of actions of exosomes in OA.
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![Fig. 1 Exosome biogenesis and its relationship with osteoarthritis. A clathrin-dependent pathway or a clathrin-independent pathway initially mediates endocytosis, at a lipid raft. The endocytic vesicles contain signaling proteins, growth factor receptors, oncoproteins, combined with normal membrane proteins, including tetraspanins (e.g., CD9, CD63, and CD81), MHC I and II, and adhesion molecules (e.g., cadherins, integrins). Exosome biogenesis occurs via the endosomal network in the endosomal sorting complexes needed for ESCRT-independent or ESCRT-dependent pathways. Inward budding of MVB produces intra-luminal vesicles (exosomes). Several cytoplasmic molecules (e.g., heat shock proteins, ubiquitin-related proteins, mRNAs, microRNAs [miRNAs], cytoskeleton proteins) and nuclear molecules (e.g., long-noncoding RNAs [lncRNAs], transcriptional factors, DNAs) can be loaded into MVB by stage-specific pathways, some of which are osteoarthritis type-specific. Moreover, plasma membrane fusion of multi-vesicular bodies leads to release of exosomes by exocytosis. Numerous Rab GTPases (such as Rab11/35, Rab7, and Rab27) are present in secreted exosomes. Eventually, MSC-derived exosomes are transported to the osteoarthritis micro-environment where they modulate osteoarthritis. ESCRT, endosomal sorting complexes required for transport; MHC, major histocompatibility complex; MSCs, mesenchymal stem cells; MVB, multi-vesicular bodies; rER, rough endoplasmic reticulum; sER, smooth endoplasmic reticulum; Rab, Ras-associated binding](/paper-figures/ce70f7204b67401283cb68add415c890/mesenchymal-stem-cell-derived-exosomes-a-new-therapeutic-approach-to-figure-1.jpg)
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“Furthermore, variability in MSC sources, such as bone marrow-derived (BM-MSCs), adipose-derived (AD-MSCs), and umbilical cord-derived MSCs (UC-MSCs), contributes to discrepancies in reported outcomes.”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [112]
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“While some trials have demonstrated substantial cartilage repair and functional improvement, others have reported minimal to no long-term benefit, particularly in advanced osteoarthritis patients [112].”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [112]
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2 retracted
RETRACTED: Exosome‐encapsulated miR‐6089 regulates inflammatory response via targeting TLR4
Xu, D., Song, M., Chai, C., Wang, J., Jin, C., Wang, X., Cheng, M., & Yan, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27014 · Cited by 74
Retracted[Differential expression of exosomal miRNAs in osteoblasts in osteoarthritis].
Liu, B., Wu, P., Mei, L., Luo, Y., Li, H., & Mao, X. (2018) · PubMed · doi:10.11817/j.issn.1672-7347.2018.12.003 · Cited by 6
RetractedKEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Silverstein, F. E., Faich, G. A., Goldstein, J. L., Simon, L. S., Pincus, T., Whelton, A., Makuch, R., Eisen, G. M., Agrawal, N. M., Stenson, W. F., et al. (2000) · JAMA · doi:10.1001/jama.284.10.1247 · Cited by 3,144
Cited by
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Items 101–200 of 276
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Advancements in the treatment of osteochondral lesions of the talus
Cheng, L., & Wang, X. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05314-6 · Cited by 30
Mesenchymal stem cells: ideal seeds for treating diseases
Gao, G., Fan, C., Li, J. W., Liang, R., Wei, C., Chen, X., Yang, Y., Zhong, Y., Shao, Y., Kong, Y., et al. (2021) · Human Cell · doi:10.1007/s13577-021-00578-0 · Cited by 29
Ragni, E., Palombella, S., Lopa, S., Talò, G., Orfei, C. P., Luca, P. D., Moretti, M., & de Girolamo, L. (2020) · Cells · doi:10.3390/cells9051180 · Cited by 32
Mesenchymal stem cell-derived exosomes: A paradigm shift in clinical therapeutics
Chattopadhyay, S., Rajendran, R. L., Chatterjee, G., Reyaz, D., Prakash, K., Hong, C. M., Ahn, B., ArulJothi, K. N., & Gangadaran, P. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114616 · Cited by 30
The Potential of Milk-Derived Exosomes for Drug Delivery
Li, S., Tang, Y., & Dou, Y. (2020) · Current Drug Delivery · doi:10.2174/1567201817666200817112503 · Cited by 30
Mini Review: Current Trends and Understanding of Exosome Therapeutic Potential in Corneal Diseases
Tiwari, A., Singh, A., Verma, S., Stephenson, S., Bhowmick, T., & Sangwan, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684712 · Cited by 32
Cell-Derived Extracellular Matrix Materials for Tissue Engineering
Guan, Y., Yang, B., Xu, W., Li, D., Wang, S., Ren, Z., Zhang, J., Zhang, T., Liu, X., Li, J., et al. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0147 · Cited by 29
The potential therapeutic role of extracellular vesicles in osteoarthritis
Zhuang, Y., Jiang, S., Yuan, C., & Lin, K. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1022368 · Cited by 29
Extracellular vesicles as novel therapeutic targets and diagnosis markers
Zhang, Y., Wu, W., Pan, X., Wang, Y., Wu, C., Lu, L., Yu, X., & Li, Y. (2022) · Extracellular Vesicle · doi:10.1016/j.vesic.2022.100017 · Cited by 28
Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease
Wang, Y., Xu, F., Zhong, J., Lin, X., Shan, S., Guo, B., Zheng, M.-H., & Yuan, L. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4378345 · Cited by 28
Kim, S. J., Kim, J. E., Choe, G., Song, D. H., Kim, S. J., Kim, T. H., Yoo, J. H., Kim, S. H., & Jung, Y. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00387-6 · Cited by 27
Xiao, M., Zeng, W., Wang, J., Yao, F., Peng, Z., Liu, G., Yu, L., Wei, W., Zhou, S., Li, K., et al. (2021) · Stem Cells and Development · doi:10.1089/scd.2020.0132 · Cited by 26
Goulian, A. J., Goldstein, B., & Saad, M. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062061 · Cited by 25
“While some trials have demonstrated substantial cartilage repair and functional improvement, others have reported minimal to no long-term benefit, particularly in advanced osteoarthritis patients [112].”
Aging microenvironment in osteoarthritis focusing on early-stage alterations and targeted therapies
Dang, Y., Liu, Y., Zhang, B., & Zhang, X. (2025) · Bone Research · doi:10.1038/s41413-025-00465-6 · Cited by 30
Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future
Abreu, H., Canciani, E., Raineri, D., Cappellano, G., Rimondini, L., & Chiocchetti, A. (2021) · Cells · doi:10.3390/cells11010043 · Cited by 26
Umbilical Cord–Derived Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review
Dhillon, J., Kraeutler, M. J., Belk, J. W., & Scillia, A. J. (2022) · Orthopaedic Journal of Sports Medicine · doi:10.1177/23259671221104409 · Cited by 25
Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases
Feng, Y., Guo, K., Jiang, J., & Lin, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116008 · Cited by 24
Wu, J., Wu, J., Liu, Z., Gong, Y., Feng, D., Xiang, W., Fang, S., Chen, R., Wu, Y., Huang, S., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.07.005 · Cited by 25
Feng, K., Liu, J., Gong, L., Ye, T., Chen, Z., Wang, Y., Li, Q., & Xie, X. (2025) · Advanced Science · doi:10.1002/advs.202413759 · Cited by 26
Li, H., Jin, Y., Zhao, Y., Li, W., He, Z., Zhang, Q., Huang, H., Lin, J., Chen, Y., Xing, D., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120994 · Cited by 24
The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment
Zhang, H., Yang, M., Wu, X., Li, Q., Li, X., Zhao, Y., Du, F., Chen, Y., Wu, Z., Xiao, Z., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105785 · Cited by 23
Li, B., Ding, T., Chen, H., Li, C., Chen, B., Xu, X. Y., Huang, P., Hu, F., & Guo, L. (2023) · Bone and Joint Research · doi:10.1302/2046-3758.121.bjr-2022-0231.r1 · Cited by 28
Li, B., Shen, E., Wu, Z., Qi, H., Wu, C., Liu, D., & Jiang, X. (2024) · Cartilage · doi:10.1177/19476035241245805 · Cited by 23
Characterization of Urine Stem Cell-Derived Extracellular Vesicles Reveals B Cell Stimulating Cargo
Zidan, A. A., Al‐Hawwas, M., Perkins, G. B., Mourad, G. M., Stapledon, C. J. M., Bobrovskaya, L., Zhou, X., & Hurtado, P. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010459 · Cited by 24
Li, X., Chen, R., Li, Y., Wang, P., Cui, Y. R., Yang, L., Zhu, X., & Zhang, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642646 · Cited by 25
Zeng, Z., Dai, Y. M., Deng, S., Zou, S., Dou, T., & Wei, F. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2038192 · Cited by 23
Morente-López, M., Mato-Basalo, R., Lucio-Gallego, S., Silva-Fernández, L., Rodríguez, A. G., Toro, F. J. D., Fafián‐Labora, J., & Arufe, M. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04580-z · Cited by 23
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Chen, J., Tan, Y., Chen, Z., Yang, H., Li, X., Long, X., Han, Y., & Yang, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113397 · Cited by 22
Zhang, X., Liu, S., Wang, Z., Luo, C., Dai, Z., Sun, J., Liu, Y., Shao, Z., Yang, S., Wang, H., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129140 · Cited by 21
The potential roles of exosomal noncoding RNAs in osteosarcoma
Li, S., & Wang, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30101 · Cited by 22
Regenerative methods in osteoarthritis
Şahin, N., & Yeşil, H. (2023) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2023.101824 · Cited by 21
Forteza‐Genestra, M. A., Antich-Rosselló, M., Ráez-Meseguer, C., Tomás, A., Calvo, J., Gayà, A., Monjo, M., & Ramis, J. M. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.10.005 · Cited by 21
Aziziyan, F., Asl, S. S., Mahdipour, M., Fard, R. R., & Sheykhhasan, M. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04879-1 · Cited by 24
Qiao, K., Chen, Q., Cao, Y., Li, J., Xu, G., Liu, J., Cui, X., Tian, K., & Zhang, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.698614 · Cited by 20
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Maleki, B., Alani, B., Zadeh, S. S. T., Saadat, S., Rajabi, A., Ayoubzadeh, S. M. J., Verdi, J., Farrokhian, A., Ghanbarian, H., Noureddini, M., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153701 · Cited by 21
Xu, H., Lee, C., Wang, Y.-F., Huang, S., Shin, L.-Y., Wang, Y., Wan, Z., Zhu, X., Yung, P. S., & Lee, O. K. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.587052 · Cited by 20
Xu, L., Zhang, F., Cheng, G., Yuan, X., Wu, Y., Wu, H., Wang, Q., Chen, J., Kuai, J., Chang, Y., et al. (2022) · Inflammation Research · doi:10.1007/s00011-022-01655-2 · Cited by 19
Chi, P., Cheng, C.-C., Wang, M.-T., Liao, J.-B., Kuo, S., Lin, K.-C., Shen, M.-C., & Huang, W. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvad185 · Cited by 19
Wang, Z., Hu, Z., Niu, L., Xu, Y., & Qi, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1588841 · Cited by 20
Lee, C., Chen, Y., Hsiao, A. W., Wang, A. Y.-F., Shen, O. Y.-J., Wang, B. Y., Ho, L. W. C., Lin, W., Choi, C. H. J., & Lee, O. K. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.11.003 · Cited by 19
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Li, C., & Hu, Y. (2023) · International Journal of Stem Cells · doi:10.15283/ijsc21177 · Cited by 18
Fath, M. K., Anjomrooz, M., Taha, S. R., Zadeh, M. S., Sahraei, M., Atbaei, R., Naghibi, A. F., Payandeh, Z., Rahmani, Z., & Barati, G. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154024 · Cited by 15
Dieterle, M. P., Groß, T., Steinberg, T., Tomakidi, P., Becker, K., Vach, K., Kremer, K., & Proksch, S. (2022) · Cells · doi:10.3390/cells11203204 · Cited by 15
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Hu, Y., Liu, H., Xu, D., Xu, X. J., & Xu, X. G. (2023) · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · doi:10.55095/achot2023/032 · Cited by 15
Chen, J., Ni, X., Yang, J. M., Yang, H., Liu, X., Chen, M., Sun, C., & Wang, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18327 · Cited by 15
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Lee, S. H., Han, J. W., Yang, J. Y., Lyu, J., Park, H. S., Bang, J. H., Kim, Y., Chang, H. S., & Park, T. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168925 · Cited by 17
Xiao, X., Zhang, N., Long, Y., & Huang, G. (2022) · Oral Diseases · doi:10.1111/odi.14476 · Cited by 14
Mesenchymal stem cell-derived extracellular vesicles, osteoimmunology and orthopedic diseases
Ma, M., Cui, G., Liu, Y., Tang, Y., Lu, X., Yue, C., & Zhang, X. Z. (2023) · PeerJ · doi:10.7717/peerj.14677 · Cited by 16
Li, D., Gupta, P., Sgaglione, N. A., & Grande, D. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10092001 · Cited by 14
Zhang, B., Tian, X., Qu, Z., Liu, J., Yang, L., & Zhang, W. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0047 · Cited by 14
Advances on biological functions of exosomal non‐coding RNAs in osteoarthritis
Chen, J., Yu, X. Y., & Zhang, X. (2021) · Cell Biochemistry and Function · doi:10.1002/cbf.3679 · Cited by 14
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Shahi, M., Mohammadnejad, D., Karimipour, M., Rasta, S. H., Rahbarghazi, R., & Abedelahi, A. (2020) · Current Molecular Medicine · doi:10.2174/1566524020666200326095837 · Cited by 14
Liu, Y., Huang, K., Zhou, S., Li, S., Si, H., Zeng, Y., Xie, H., & Shen, B. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2843-7 · Cited by 14
Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
Ge, Y., Wang, J., Zhang, H., Li, J., Ye, M., & Jin, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.11093 · Cited by 13
Lin, J., Yang, Z., Wang, L., Xing, D., & Lin, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.956058 · Cited by 14
Zhou, J., Peng, S., Xu, J., Cheng, X., Wang, X. D., Tao, J., Dai, H., & Cao, X. (2024) · The FASEB Journal · doi:10.1096/fj.202400448rr · Cited by 13
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Zhang, H., Jin, C., Hua, J., Chen, Z., Gao, W., Xu, W., Zhou, L., & Shan, L. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s475617 · Cited by 14
Shipman, W. D., Fonseca, R., Dominguez, M., Bhayani, S., Gilligan, C. J., Diwan, S. A., Rosenblum, D., Ashina, S., Tolba, R., Abd-Elsayed, A. A., et al. (2024) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01309-4 · Cited by 13
Dawood, R. M., & Mahdee, A. F. (2025) · Polymers · doi:10.3390/polym17050596 · Cited by 13
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Wong, K. U., Zhang, A., Akhavan, B., Bilek, M., & Yeo, G. C. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01538 · Cited by 13
Ren, Z., Liu, X., Abdollahi, E., & Tavasolian, F. (2023) · Biopreservation and Biobanking · doi:10.1089/bio.2022.0003 · Cited by 13
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Self-citationLiang, H., Li, D., Neufeld, E. V., Sayegh, M. J., Kiridly, A., Palacios, P., Andriamifidy, H. F., Swami, P. N., Zaslav, K. R., Sgaglione, N. A., et al. (2023) · Journal of Cartilage & Joint Preservation · doi:10.1016/j.jcjp.2023.100146 · Cited by 12
Zhai, Y., Wang, Q., Zhu, Z., Zheng, W., Ma, S., Hao, Y., Yang, L., & Cheng, G. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac4089 · Cited by 12
Dechêne, L., Colin, M., Demazy, C., Fransolet, M., Niesten, A., Arnould, T., Serteyn, D. A., Dieu, M., & Renard, P. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10463-4 · Cited by 11
Fath, M. K., Banan, Z. M., Barati, R., Mohammadrezakhani, O., Ghaderi, A., Hatami, A., Ghiabi, S., Zeidi, N., Asgari, K., Payandeh, Z., et al. (2023) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2023.02.001 · Cited by 10
Frontier review of the roles of exosomes in osteoarthritis
Liu, D.-H., Jheng, Y.-C., Chen, P.-Y., Yarmishyn, A. A., Huang, S.-E., Chien, C.-S., Tsai, P.-H., Chien, Y., Yang, Y.-P., & Kao, C.-L. (2021) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000570 · Cited by 11
Li, P. A., Cao, L., Liu, T., Lu, X., Ma, Y., & Wang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020479 · Cited by 10
Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Lan, D., Zhang, D., Dai, X., Ji, C., Zhou, H., Song, T., Wang, X., Kong, Q., Tang, Z., Tan, J., et al. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112781 · Cited by 10
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Ragni, E., Orfei, C. P., Papait, A., & de Girolamo, L. (2021) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2021.11 · Cited by 9
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Yang, D., Chen, Z., Xu, Z., Qin, L., Yi, W., & Long, Y. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220817093305 · Cited by 9
Li, K., Zhu, Z., Sun, X., Zhao, L., Liu, Z., & Xing, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115201 · Cited by 9
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Metadata
- Authors
- Mianehsaz, E., Mirzaei, H. R., Mahjoubin-Tehran, M., Rezaee, A., Sahebnasagh, R., Pourhanifeh, M. H., Mirzaei, H., & Hamblin, M. R.
- Affiliations
- Kashan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Harvard University (US)
- Corresponding author
- Mirzaei, Hamid Reza
- Mirzaei, Hamed
- Hamblin, Michael R.
- ORCID
- Venue
- Stem Cell Research & Therapy
- Published
- 2019-11-21
- Volume
- 10
- Issue
- 1
- Pages
- 340-340
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC6873475
- OpenAlex
- W2990542915
- Cited by
- 274
- References
- 126
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 35 · 2023: 44 · 2022: 45 · 2021: 74 · 2020: 33
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI050875, R21AI121700)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- mesenchymal stem cells, exosomes, osteoarthritis, cartilage degeneration, extracellular matrix, paracrine signaling, matrix metalloproteinases, ADAMTS, inflammatory cytokines, tissue regeneration, stem cell therapy
- MeSH terms
- Animals, Humans, Osteoarthritis, Exosomes, Mesenchymal Stem Cells
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