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Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Open accessAbstract
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from liver cirrhosis, liver failure, or hepatocellular carcinoma. Liver transplantation is currently limited by few liver donors, expensive surgical costs, and severe immune rejection. Cell therapy, including hepatocyte transplantation and stem cell transplantation, has recently become an attractive option to reduce the overall need for liver transplantation and reduce the wait time for patients. Recent studies showed that mesenchymal stem cell (MSC) administration was a promising therapeutic approach for promoting liver regeneration and repairing liver injury by the migration of cells into liver sites, hepatogenic differentiation, immunoregulation, and paracrine mechanisms. MSCs secrete a large number of molecules into the extracellular space, and soluble proteins, free nucleic acids, lipids, and extracellular vesicles (EVs) effectively repair tissue injury in response to fluctuations in physiological states or pathological conditions. Cell-free-based therapies avoid the potential tumorigenicity, rejection of cells, emboli formation, undesired differentiation, and infection transmission of MSC transplantation. In this review, we focus on the potential mechanisms of MSC-based cell-free strategies for attenuating liver injury in various liver diseases. Secretome-mediated paracrine effects participate in the regulation of the hepatic immune microenvironment and promotion of hepatic epithelial repair. We look forward to completely reversing liver injury through an MSC-based cell-free strategy in regenerative medicine in the near future.
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“newer research has determined their phenomenal plasticity, including their potency to differentiate into hepatocyte-like cells (HLCs)([39, 40]”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [40]
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Fitzmaurice, C., Allen, C., Barber, R. M., Barregård, L., Bhutta, Z. A., Brenner, H., Dicker, D., Chimed‐Ochir, O., Dandona, R., Dandona, L., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5688 · Cited by 6,318
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Burden of liver diseases in the world
Asrani, S. K., Devarbhavi, H., Eaton, J., & Kamath, P. S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.014 · Cited by 3,783
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832
Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O. M., Abdelalim, A., Abdoli, A., Abdollahpour, I., Abdulle, A. M., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.2996 · Cited by 2,521
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,380
Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells
Parolini, I., Federici, C., Raggi, C., Lugini, L., Palleschi, S., Milito, A. D., Coscia, C., Iessi, E., Logozzi, M., Molinari, A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041152 · Cited by 1,614
Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,251
Polson, J., & Lee, W. M. (2005) · Hepatology · doi:10.1002/hep.20703 · Cited by 983
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy
Lee, Y., Andaloussi, S. E., & Wood, M. J. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds317 · Cited by 958
van der Pol, E., Coumans, F. A. W., Grootemaat, A. E., Gardiner, C., Sargent, I. L., Harrison, P., Sturk, A., van Leeuwen, T. G. J. M., & Nieuwland, R. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12602 · Cited by 947
Ethical and Safety Issues of Stem Cell-Based Therapy
Volarević, V., Marković, B. S., Gazdic, M., Volarevic, A., Jovicic, N. U., Arsenijević, N., Armstrong, L., Djonov, V., Lako, M., & Stojković, M. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.21666 · Cited by 933
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis
Li, T., Yan, Y., Wang, B., Qian, H., Zhang, X., Shen, L., Wang, M., Zhou, Y., Zhu, W. Z., Li, W., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0395 · Cited by 882
Eggenhofer, E., Benseler, V., Kroemer, A., Popp, F. C., Geissler, E. K., Schlitt, H. J., Baan, C. C., Dahlke, M. H., & Hoogduijn, M. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00297 · Cited by 804
Multivesicular Endosome Biogenesis in the Absence of ESCRTs
Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 791
Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726
Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?
Malhi, H., Gores, G. J., & Lemasters, J. J. (2006) · Hepatology · doi:10.1002/hep.21062 · Cited by 694
Pathogenesis of liver cirrhosis
Zhou, W.-C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7312 · Cited by 664
Sotiropoulou, P. A., Perez, S. A., Salagianni, M. L., Baxevanis, C. N., & Papamichail, M. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0331 · Cited by 647
Madrigal, M., Rao, K. S. J., & Riordan, N. H. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0260-8 · Cited by 637
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
Jaeschke, H., & Lemasters, J. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01209-5 · Cited by 596
Mesenchymal stem cell exosomes
Lai, R. C., Yeo, R. W. Y., & Lim, S. K. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.001 · Cited by 589
Apoptosis and necroptosis in the liver: a matter of life and death
Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582
Miura, M., Miura, Y., Padilla‐Nash, H. M., Molinolo, A., Fu, B., Patel, V., Seo, B., Sonoyama, W., Zheng, J. J., Baker, C. C., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0403 · Cited by 581
Zhu, L., Tian, T., Wang, J., He, J., Chen, T., Pan, M., Li, X., Zhang, H., Qiu, X., Li, C., et al. (2018) · Theranostics · doi:10.7150/thno.28021 · Cited by 560
Morphological and Biochemical Aspects of Apoptosis, Oncosis and Necrosis
Cruchten, S. J. M. V., & Broeck, W. V. D. (2002) · Anatomia Histologia Embryologia · doi:10.1046/j.1439-0264.2002.00398.x · Cited by 558
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553
Anderson, J. D., Johansson, H. J., Graham, C. S., Vesterlund, M., Pham, M. T., Bramlett, C. S., Montgomery, E. N., Mellema, M., Bardini, R. L., Contreras, Z., et al. (2016) · Stem Cells · doi:10.1002/stem.2298 · Cited by 546
Lai, R. C., Tan, S. S., Teh, B. J., Sze, S. K., Arslan, F., de Kleijn, D. P. V., Choo, A. B. H., & Lim, S. K. (2012) · International Journal of Proteomics · doi:10.1155/2012/971907 · Cited by 488
The Life and Fate of Mesenchymal Stem Cells
Eggenhofer, E., Luk, F., Dahlke, M. H., & Hoogduijn, M. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00148 · Cited by 446
Barkholt, L., Flory, E., Jekerle, V., Lucas-Samuel, S., Ahnert, P., Bisset, L., Büscher, D., Fibbe, W. E., Foussat, A., Kwa, M. S. G., et al. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.03.005 · Cited by 420
The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis
Trump, B. E., Berezesky, I. K., Chang, S. H., & Phelps, P. C. (1997) · Toxicologic Pathology · doi:10.1177/019262339702500116 · Cited by 415
Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells
Kim, H.-S., Choi, D., Yun, S. J., Choi, S., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P., & Kim, D. (2011) · Journal of Proteome Research · doi:10.1021/pr200682z · Cited by 398
Qu, Y., Zhang, Q., Cai, X., Li, F., Ma, Z., Xu, M., & Lu, L. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13170 · Cited by 391
Osugi, M., Katagiri, W., Yoshimi, R., Inukai, T., Hibi, H., & Ueda, M. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0325 · Cited by 385
Salomón, C., Ryan, J., Sobrevía, L., Kobayashi, M., Ashman, K., Mitchell, M. D., & Rice, G. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068451 · Cited by 345
Görgens, A., Bremer, M., Ferrer-Tur, R., Murke, F., Tertel, T., Horn, P. A., Thalmann, S., Welsh, J. A., Probst, C., Guérin, C. L., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1587567 · Cited by 344
Defining the risks of mesenchymal stromal cell therapy
Prockop, D. J., Brenner, M. K., Fibbe, W. E., Horwitz, E. M., Blanc, K. L., Phinney, D. G., Simmons, P. J., Sensebé, L., & Keating, A. (2010) · Cytotherapy · doi:10.3109/14653249.2010.507330 · Cited by 339
Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes
Rodríguez‐Enríquez, S., Kim, I., Currin, R. T., & Lemasters, J. J. (2006) · Autophagy · doi:10.4161/auto.2229 · Cited by 331
Rong, X., Liu, J., Yao, X., Jiang, T., Wang, Y., & Xie, F. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1204-2 · Cited by 331
hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury
Yan, Y., Jiang, W., Tan, Y., Zou, S., Zhang, H., Mao, F., Gong, A., Qian, H., & Xu, W. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.11.019 · Cited by 329
Is the intravascular administration of mesenchymal stem cells safe?
Furlani, D., Uğurlucan, M., Ong, L., Bieback, K., Pittermann, E., Westien, I., Wang, W., Yerebakan, C., Li, W., Gaebel, R., et al. (2009) · Microvascular Research · doi:10.1016/j.mvr.2009.02.001 · Cited by 327
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
Roychowdhury, S., McMullen, M. R., Pisano, S. G., Liu, X., & Nagy, L. E. (2013) · Hepatology · doi:10.1002/hep.26200 · Cited by 304
Das, R., Jahr, H., van Osch, G. J. V. M., & Farrell, E. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0296 · Cited by 297
Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency
Willis, G. R., Kourembanas, S., & Mitsialis, S. A. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00063 · Cited by 267
Exosomes in clinical trial and their production in compliance with good manufacturing practice
Harn, H., Chen, Y.-S., Lin, E.-Y., & Chiou, T. (2019) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_182_19 · Cited by 265
RAL-1 controls multivesicular body biogenesis and exosome secretion
Hyenne, V., Apaydin, A., Rodriguez, D., Spiegelhalter, C., Hoff-Yoessle, S., Diem, M., Tak, S., Lefèbvre, O., Schwab, Y., Goetz, J. G., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201504136 · Cited by 244
New insight into isolation, identification techniques and medical applications of exosomes
Yang, X., Sun, C., Wang, L., & Guo, X. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.021 · Cited by 243
Chen, L., Lu, F., Chen, D., Wu, J., Hu, E.-D., Xu, L., Zheng, M., Li, H., Huang, Y., Jin, X., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.11.008 · Cited by 223
Mesenchymal Stem Cell Delivery Routes and Fate
Kurtz, A. (2008) · International Journal of Stem Cells · doi:10.15283/ijsc.2008.1.1.1 · Cited by 219
Integrated systems for exosome investigation
Peterson, M., Otoc, N., Sethi, J. K., Gupta, A. A., & Antes, T. J. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.015 · Cited by 217
Liu, Y., Lou, G., Li, A., Zhang, T., Qi, J., Ye, D., Zheng, M., & Chen, Z. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.054 · Cited by 216
Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure
Chen, L., Xiang, B., Wang, X., & Xiang, C. C. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0453-6 · Cited by 198
Exosomes and the Emerging Field of Exosome-Based Gene Therapy
O’Loughlin, A. J., Woffindale, C., & Wood, M. J. A. (2012) · Current Gene Therapy · doi:10.2174/156652312802083594 · Cited by 193
Jiang, W., Tan, Y., Cai, M., Zhao, T., Mao, F., Zhang, X., Xu, W., Yan, Z., Qian, H., & Yan, Y. (2018) · Stem Cells International · doi:10.1155/2018/6079642 · Cited by 188
Huang, B., Cheng, X., Wang, H., Huang, W., la Ga hu, Z., Wang, D., Zhang, K., Zhang, H., Xue, Z., Da, Y., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0792-1 · Cited by 183
Kilpinen, L., Impola, U., Sankkila, L., Ritamo, I., Aatonen, M., Kilpinen, S. K., Tuimala, J., Valmu, L., Levijoki, J. M., Finckenberg, P., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.21927 · Cited by 169
Eirin, A., Zhu, X.-Y., Puranik, A. S., Woollard, J. R., Tang, H., Dasari, S., Lerman, A., van Wijnen, A. J., & Lerman, L. O. (2016) · Scientific Reports · doi:10.1038/srep36120 · Cited by 159
Chen, L., Qu, J., Cheng, T., Chen, X., & Xiang, C. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1503-7 · Cited by 149
Du, Y., Li, D., Han, C., Wu, H., Xu, L., Zhang, M., Zhang, J., & Chen, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480533 · Cited by 143
Tamura, R., Üemoto, S., & Tabata, Y. (2016) · Inflammation and Regeneration · doi:10.1186/s41232-016-0030-5 · Cited by 137
Nizamudeen, Z. A., Márkus, R., Lodge, R. W., Parmenter, C. D. J., Platt, M., Chakrabarti, L., & Sottile, V. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.09.008 · Cited by 125
Zhang, B., Shen, L., Shi, H., Pan, Z., Wu, L., Yan, Y., Zhang, X., Mao, F., Qian, H., & Xu, W. (2016) · Stem Cells International · doi:10.1155/2016/1929536 · Cited by 120
Beer, L., Mildner, M., & Ankersmit, H. J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.03.50 · Cited by 119
Lindenmair, A., Hatlapatka, T., Kollwig, G., Hennerbichler, S., Gabriel, C., Wolbank, S., Redl, H. R., & Kasper, C. (2012) · Cells · doi:10.3390/cells1041061 · Cited by 115
Jiang, L., Zhang, S., Hu, H., Yang, J., Wang, X., Ma, Y., Jiang, J., Wang, J., Zhong, L., Chen, M., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.189 · Cited by 109
Mechanisms of Hepatocyte Injury, Multiorgan Failure, and Prognostic Criteria in Acute Liver Failure
Riordan, S. M., & Williams, R. (2003) · Seminars in Liver Disease · doi:10.1055/s-2003-42639 · Cited by 104
Acute‐on‐Chronic Liver Failure: Getting Ready for Prime Time?
Bajaj, J. S., Moreau, R., Kamath, P. S., Vargas, H. E., Arroyo, V., Reddy, K. R., Szabó, G., Tandon, P., Olson, J. C., Karvellas, C. J., et al. (2018) · Hepatology · doi:10.1002/hep.30056 · Cited by 103
Shi, D., Zhang, J., Zhou, Q., Xin, J., Jiang, J., Jiang, L., Wu, T., Jiang, L., Ding, W., Li, ., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-311146 · Cited by 100
Self-citationDu, Z., Wei, C., Cheng, K., Han, B., Yan, J., Zhang, M., Peng, C., & Liu, Y. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.02.009 · Cited by 91
The Role of Hypoxia in Stem Cell Potency and Differentiation
Hawkins, K. E., Sharp, T. V., & McKay, T. R. (2013) · Regenerative Medicine · doi:10.2217/rme.13.71 · Cited by 87
Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis
Bermúdez, M. A., Sendón-Lago, J., Seoane, S., Eiró, N., González, F., Saá, J., Vizoso, F. J., & Pérez-Fernández, R. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.06.022 · Cited by 86
Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry
Danielson, K., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., Khoory, J. A., Kreimer, S. D., Ivanov, A. R., Mantel, P., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144678 · Cited by 84
Lee, S. C., Jeong, H. J., Lee, S. K., & Kim, S. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0191 · Cited by 84
Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases
Hu, C., Zhao, L., & Li, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1310-1 · Cited by 81
Self-citationKabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.291963 · Cited by 80
Pacienza, N., Lee, R. H., Bae, E., Kim, D.-K., Liu, Q., Prockop, D. J., & Yannarelli, G. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.12.003 · Cited by 75
Angulski, A. B. B., Capriglione, L. G. A., Batista, M., Marcon, B. H., Senegaglia, A. C., Stimamiglio, M. A., & Correa, A. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9715-z · Cited by 74
Lee, C. A., Sinha, S., Fitzpatrick, E., & Dhawan, A. K. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1638-5 · Cited by 74
Sun, C., Chen, C., Chang, C.-L., Chiang, H., Sung, P., Chen, K., Chen, Y., Chen, S.-Y., Kao, G., Chang, H., et al. (2017) · PubMed Central · Cited by 74
Greca, A. L., Solari, C., Furmento, V. A., Lombardi, A., Biani, M. C., Abán, C. E., Moro, L. N., García, M. N., Guberman, A., Sevlever, G. E., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0142-x · Cited by 71
Chen, Y., Zeng, Z., Sun, J., Zeng, H., Huang, Y., & Zhang, Z.-Y. (2015) · Journal of Radiation Research · doi:10.1093/jrr/rrv026 · Cited by 70
Hu, C., Zhao, L., Wu, D., & Li, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1225-x · Cited by 70
Self-citationZhang, S., Yang, Y., Fan, L., Zhang, F., & Li, L. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.03.218 · Cited by 58
Self-citationDistinguishing between apoptosis, necrosis, necroptosis and other cell death modalities
Martin, S. J., & Henry, C. M. (2013) · Methods · doi:10.1016/j.ymeth.2013.06.001 · Cited by 57
Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2
Sanz‐García, C., Ferrer‐Mayorga, G., González‐Rodríguez, Á., Valverde, Á. M., Martín‐Duce, A., Velasco-Martin, J. P., Regadera, J., Fernández, M., & Alemany, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439547 · Cited by 49
HIF-1α Confers Resistance to Induced Stress in Bone Marrow-derived Mesenchymal Stem Cells
Kiani, A. A., Kazemi, A., Halabian, R., Mohammadipour, M., Jahanian‐Najafabadi, A., & Roudkenar, M. H. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.03.006 · Cited by 42
Chen, L., Zhang, J., Yang, L., Zhang, G., Wang, Y., & Zhang, S.-C. (2018) · Stem Cells International · doi:10.1155/2018/9156560 · Cited by 35
Hikita, H., Takehara, T., Kodama, T., Shimizu, S., Shigekawa, M., Hosui, A., Miyagi, T., Tatsumi, T., Ishida, H., Li, W., et al. (2011) · Hepatology · doi:10.1002/hep.24305 · Cited by 32
Mafanda, E. K., Kandhi, R., Bobbala, D., Khan, M. G. M., Nandi, M., Menéndez, A., Ramanathan, S., & Ilangumaran, S. (2018) · Cytokine · doi:10.1016/j.cyto.2018.07.032 · Cited by 26
Kim, Y., Cho, K., Park, M., Kim, H. S., Park, J., Woo, S., & Ryu, K. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0160-8 · Cited by 24
Темнов, А. А., Рогов, К. А., Zhalimov, V., Igor, P., Игоревич, П. С., Bader, A., Склифас, А. Н., & Giri, S. (2019) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s196354 · Cited by 18
Темнов, А. А., Рогов, К. А., Склифас, А. Н., Klychnikova, E. V., Hartl, M., Djinović‐Carugo, K., & Charnagalov, A. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04765-z · Cited by 15
Knocking on the door to successful hepatocyte transplantation
Forbes, S. J., & Alison, M. R. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.44 · Cited by 14
Yang, X., He, C., Zhu, L., Zhao, W., Li, S., Xia, C., & Xu, C. (2018) · Biochemical Genetics · doi:10.1007/s10528-018-9869-2 · Cited by 13
Hu, C., Cao, H., Pan, X., Li, J., He, J., Pan, Q., Xin, J., Yu, X., Li, J., Wang, Y.-N., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.1 · Cited by 10
Self-citationMiceli, M., Baldi, D., Cavaliere, C., Soricelli, A., Salvatore, M., & Claudio Napoli, A. (2019) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1635012 · Cited by 8
Research works printed but not linked: 1
- Michalopoulos GK, DeFrances M. Liver regeneration. Adv Biochem Eng Biotechnol. 2005;93:101–34.
Cited by
Sorted by citations
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Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
Lin, Y., Yan, M., Bai, Z., Xie, Y., Ren, L., Wei, J., Zhu, D., Wang, H., Liu, Y., Luo, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01636-x · Cited by 125
Li, M., Jiang, Y., Hou, Q., Zhao, Y., Zhong, L., & Fu, X. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02822-2 · Cited by 119
Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
Liu, P., Mao, Y., Xie, Y., Wei, J., & Yao, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03041-5 · Cited by 82
Molecular Mechanisms and Potential New Therapeutic Drugs for Liver Fibrosis
Wang, F.-D., Zhou, J., & Chen, E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.787748 · Cited by 79
Metadata
- Authors
- Hu, C., Zhao, L., Zhang, L., Bao, Q., & Li, L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Li, Lanjuan
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-09-03
- Volume
- 11
- Issue
- 1
- Pages
- 377-377
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7469278
- OpenAlex
- W3082320282
- Cited by
- 130
- References
- 103
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 23 · 2023: 35 · 2022: 28 · 2021: 15
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81700553)
- Zhejiang basic public welfare research program (LGF20H030008)
- Independent Fund of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University (N/A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- mesenchymal stem cells, cell-free therapy, liver injury, liver regeneration, extracellular vesicles, secretome, paracrine signaling, hepatocyte transplantation, liver transplantation alternatives, liver cirrhosis, liver failure, hepatocellular carcinoma, immune regulation, hepatic immune microenvironment, hepatocyte differentiation
- MeSH terms
- Extracellular Vesicles, Humans, Liver Diseases, Liver Regeneration, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells
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