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Cited by 119Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

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Li, Meirong, Jiang, Yufeng, Hou, Qian, Zhao, Yali, Zhong, Lingzhi, Fu, Xiaobing·2022·Stem Cell Research & Therapy
DOI 10.1186/s13287-022-02822-2PMC PMC8981790
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Abstract

Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.

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Cited by

Sorted by citations

Authors
Li, M., Jiang, Y., Hou, Q., Zhao, Y., Zhong, L., & Fu, X.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • Chinese PLA General Hospital (CN)
Corresponding author
  • Li, Meirong
  • Fu, Xiaobing
ORCID
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-04-04
Volume
13
Issue
1
Pages
146-146
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/s13287-022-02822-2
PMC
PMC8981790
OpenAlex
W4226053415
Cited by
119
References
6
Citations by year
2026: 22 · 2025: 27 · 2024: 32 · 2023: 30 · 2022: 8
FWCI
4.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the National Nature Science Foundation of China (81971841, 81721092, 81941021, 81901973)
  • the National Key Research and Development Plan (2017YFC1104701, 2017YFC1103304, 2018YFC2000400)
  • the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-059)
  • the Military Medical Research and Development Projects (AWS17J005, 2019-126)
  • The National S&T Resource Sharing service platform Project of China (YCZYPT[2018]07)
  • the General Hospital of PLA Medical Big Data R&D Project (MBD2018030)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
mesenchymal stem cells, stem cell therapy, engraftment, stem cell survival, genetic engineering, immunomodulation, multilineage differentiation, regenerative capacity
MeSH terms
Cell Differentiation, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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