Study design to evaluate a group-based therapy for support persons of adults on buprenorphine/naloxone
Open accessAbstract
Background: Opioid use disorders (OUDs) have devastating effects on individuals, families, and communities. While medication treatments for OUD save lives and are increasingly utilized, rates of treatment dropout are very high. In addition, most existing medication treatments for OUD may often neglect the impact of untreated OUD on relationships and ignore the potential role support persons (SPs) could have on encouraging long-term recovery, which can also impact patient treatment retention. Methods/design: The current study adapts Community Reinforcement and Family Training (CRAFT) for use with SPs (family member, spouse or friend) of patients using buprenorphine/naloxone (buprenorphine) in an outpatient community clinic setting. The study will evaluate whether the adapted intervention, also known as integrating support persons into recovery (INSPIRE), is effective in increasing patient retention on buprenorphine when compared to usual care. We will utilize a two-group randomized design where patients starting or restarting buprenorphine will be screened for support person status and recruited with their support person if eligible. Support persons will be randomly assigned to the INSPIRE intervention, which will consist of 10 rolling group sessions led by two facilitators. Patients and SPs will each be assessed at baseline, 3 months post-baseline, and 12 months post-baseline. Patient electronic medical record data will be collected at six and 12 months post-baseline. We will examine mechanisms of intervention effectiveness and also conduct pre/post-implementation surveys with clinic staff to assess issues that would affect sustainability. Discussion: Incorporating the patient’s support system may be an important way to improve treatment retention in medication treatments for OUD. If SPs can serve to support patient retention, this study would significantly advance work to help support the delivery of effective treatments that prevent the devastating consequences associated with OUD. Trial registration This study was registered with ClinicalTrials.gov, NCT04239235. Registered 27 January 2020,https://clinicaltrials.gov/ct2/show/NCT04239235.
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The INSPIRE developers are working with primary care systems and funding agency representatives to evaluate its clinical and economic impacts in a pragmatic clinical trial.
“The INSPIRE developers are working with primary care systems and funding agency representatives to evaluate its clinical and economic impacts in a pragmatic clinical trial [55].”
From Translating economic evaluations into financing strategies for implementing evidence-based practices (2021) · cites this paper as [55]
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Translating economic evaluations into financing strategies for implementing evidence-based practices
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- Authors
- Osilla, K. C., Becker, K., Ecola, L., Hurley, B., Manuel, J. K., Ober, A., Paddock, S. M., & Watkins, K. E.
- Affiliations
- RAND Corporation (US)
- Los Angeles County Department of Health Services (US)
- University of California, San Francisco (US)
- University of Chicago (US)
- Corresponding author
- Osilla, Karen Chan
- Venue
- Addiction Science & Clinical Practice
- Published
- 2020-07-11
- Volume
- 15
- Issue
- 1
- Pages
- 25-25
- ISSN
- 1940-0632 (ISSN-L)
- 1940-0640
- PMC
- PMC7353769
- OpenAlex
- W3040911991
- Cited by
- 20
- References
- 64
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2022: 3 · 2021: 3 · 2020: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Addiction Science & Clinical Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Patient-Centered Outcomes Research Institute (OBOT-2018C2-12876)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- opioid use disorder, buprenorphine/naloxone, support persons, family involvement, Community Reinforcement and Family Training, treatment retention, medication-assisted treatment, group therapy, outpatient addiction treatment
- MeSH terms
- Buprenorphine, Naloxone Drug Combination, Adult, Analgesics, Opioid, Buprenorphine, California, Community Health Centers, Family, Female, Humans, Opioid-Related Disorders, Psychotherapy, Group, Social Support
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