Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis
Open accessAbstract
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatment for ALS and the cause of disease is unknown in the majority of ALS cases. Neuronal mitochondria dysfunction is one of the earliest features of ALS. Mitochondria are highly dynamic organelles that undergo continuous fission, fusion, trafficking and turnover, all of which contribute to the maintenance of mitochondrial function. Abnormal mitochondrial dynamics have been repeatedly reported in ALS and increasing evidence suggests altered mitochondrial dynamics as possible pathomechanisms underlying mitochondrial dysfunction in ALS. Here, we provide an overview of mitochondrial dysfunction and dynamic abnormalities observed in ALS, and discuss the possibility of targeting mitochondrial dynamics as a novel therapeutic approach for ALS.
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Dysfunction of mitochondrial dynamics has been reported as an early event in ALS.
“dysfunction of mitochondrial dynamics has been reported as an early event in Amyotrophic lateral sclerosis (61)”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [61]
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- Authors
- Jiang, Z., Wang, W., Perry, G., Zhu, X., & Wang, X.
- Affiliations
- Case Western Reserve University (US)
- The University of Texas at San Antonio (US)
- Corresponding author
- Wang, Xinglong
- Venue
- Translational Neurodegeneration
- Published
- 2015-07-29
- Volume
- 4
- Issue
- 1
- Pages
- 14-14
- ISSN
- 2047-9158 (ISSN-L)
- PMC
- PMC4518588
- OpenAlex
- W2108507487
- Cited by
- 66
- References
- 92
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 2
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Neurodegeneration (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (2014-NIRG-301299)
- National Institutes of Health
- National Institute on Aging (R03AG044680)
- National Institute of Neurological Disorders and Stroke (R01NS089604, R21NS085747)
- National Institute on Minority Health and Health Disparities (G12MD007591)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- amyotrophic lateral sclerosis, mitochondrial dynamics, mitochondrial dysfunction, mitochondrial fission, mitochondrial fusion, mitochondrial trafficking, motor neuron disease
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