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Cited by 156Animal Nutrition and PhysiologyVeterinary medicine and infectious diseasesAnimal Virus Infections Studies

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation.

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Jackman, Joshua A., Boyd, R. Dean, Elrod, Charles C.·2020·Journal of Animal Science and Biotechnology
DOI 10.1186/s40104-020-00446-1PMC PMC7178611
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Abstract

Ongoing challenges in the swine industry, such as reduced access to antibiotics and virus outbreaks (e.g., porcine epidemic diarrhea virus, African swine fever virus), have prompted calls for innovative feed additives to support pig production. Medium-chain fatty acids (MCFAs) and monoglycerides have emerged as a potential option due to key molecular features and versatile functions, including inhibitory activity against viral and bacterial pathogens. In this review, we summarize recent studies examining the potential of MCFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed pathogens. The molecular properties and biological functions of MCFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig production. The latest progress in testing MCFAs and monoglycerides as feed additives in pig diets is then presented, and their effects on a wide range of production issues, such as growth performance, pathogenic infections, and gut health, are covered. The utilization of MCFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described, along with advances in molecular encapsulation and delivery strategies. Finally, we discuss how MCFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease transmission. Looking forward, we envision that MCFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

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  • Medium-chain fatty acids and their monoglycerides are promising additives for replacing in-feed antibiotics and promoting sustainable animal-food production, enhancing growth performance and animal welfare.

    “MCFAs and their monoglycerides have emerged as promising additives for replacing in-feed antibiotics and promoting sustainable animal-food production, enhancing growth performance and animal welfare (Jackman et al., 2020).”

    From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Jackman et al., 2020

    The Anti-infective strategies section describes MCFAs and monoglycerides as potential antibiotic replacements, and the Growth performance section reports improved growth in some pig studies. The paper frames these as opportunities in pig production; the passages do not establish broader sustainable animal-food production or improved animal welfare. No page numbers are provided in our copy. (LLM, conf=0.85)

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  • Bacteria are unlikely to acquire resistance to lauric acid and glycerol monolaurate.

    “because these bacteria are also unlikely to acquire resistance to these compounds (Petschow et al., 1996; Schlievert and Peterson, 2012; Jackman et al., 2020).”

    From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Jackman et al., 2020

  • Lauric acid and glycerol monolaurate destabilize the bacterial cell membrane.

    “Their ability to destabilize the bacterial cell membrane makes them promising candidates among novel antimicrobials”

    From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Jackman et al., 2020

  • Monoglycerides form micelles at lower concentrations than medium-chain fatty acids, which helps explain why monoglycerides are often more biologically potent than fatty acids.

    “Monoglycerides form micelles at lower concentrations than MCFAs, which helps to clarify why monoglycerides are often more biologically potent than FAs (Jackman et al., 2020).”

    From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Jackman et al., 2020

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References 106 · Cited by 156

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Authors
Jackman, J. A., Boyd, R. D., & Elrod, C. C.
Affiliations
  • Sungkyunkwan University (KR)
  • North Carolina State University (US)
  • Cornell University (US)
Corresponding author
  • Jackman, Joshua A.
  • Elrod, Charles C.
ORCID
Venue
Journal of Animal Science and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2020-04-23
Volume
11
Issue
1
Pages
44-44
ISSN
  • 1674-9782 (ISSN-L)
  • 2049-1891
DOI
10.1186/s40104-020-00446-1
PMC
PMC7178611
OpenAlex
W3020321104
Cited by
156
References
106
Citations by year
2026: 12 · 2025: 33 · 2024: 24 · 2023: 30 · 2022: 31 · 2021: 19 · 2020: 7
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
medium-chain fatty acids, monoglycerides, feed additives, pig farming, gut health, porcine epidemic diarrhea virus, African swine fever virus, growth performance, organic acids, probiotics, antibiotic alternatives

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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