The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics
Open accessAbstract
BACKGROUND: Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic first-degree relative. Intestinal microbiota may modulate immunologic and inflammatory systemic responses and, thus, influence development of sensitization and allergy. Probiotics have been reported to modulate immune responses and their supplementation has been proposed as a preventive intervention. OBJECTIVE: The World Allergy Organization (WAO) convened a guideline panel to develop evidence-based recommendations about the use of probiotics in the prevention of allergy. METHODS: We identified the most relevant clinical questions and performed a systematic review of randomized controlled trials of probiotics for the prevention of allergy. We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations. We searched for and reviewed the evidence about health effects, patient values and preferences, and resource use (up to November 2014). We followed the GRADE evidence-to-decision framework to develop recommendations. RESULTS: Currently available evidence does not indicate that probiotic supplementation reduces the risk of developing allergy in children. However, considering all critical outcomes in this context, the WAO guideline panel determined that there is a likely net benefit from using probiotics resulting primarily from prevention of eczema. The WAO guideline panel suggests: a) using probiotics in pregnant women at high risk for having an allergic child; b) using probiotics in women who breastfeed infants at high risk of developing allergy; and c) using probiotics in infants at high risk of developing allergy. All recommendations are conditional and supported by very low quality evidence. CONCLUSIONS: WAO recommendations about probiotic supplementation for prevention of allergy are intended to support parents, clinicians and other health care professionals in their decisions whether to use probiotics in pregnancy and during breastfeeding, and whether to give them to infants.
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“These guidelines concluded that currently there is no evidence supporting probiotic supplementation for reducing the risk of allergy incidence in children. However, there is likely to be a net benefit using probiotics for eczema prevention, which requires further clinical trials to increase the sample size and the reliability of the results.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [166]
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1 retracted
Vitamin D supplementation in pregnancy
Mahomed, K., & Gülmezoglu, A. M. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000228.pub2 · Cited by 91
RetractedHolick, M. F., Binkley, N., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,961
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Gibson, G. R., Probert, H. M., Loo, J. V., Rastall, R. A., & Roberfroid, M. B. (2004) · Nutrition Research Reviews · doi:10.1079/nrr200479 · Cited by 2,539
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
GRADE guidelines: 2. Framing the question and deciding on important outcomes
Guyatt, G. H., Oxman, A. D., Kunz, R., Atkins, D., Brozek, J., Vist, G., Alderson, P., Glasziou, P., Falck-Ytter, Y., & Schünemann, H. J. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.09.012 · Cited by 1,911
Self-citationGuidelines for the Diagnosis and Management of Food Allergy in the United States
Boyce, J. A., Assa'ad, A., Burks, A., Jones, S., Sampson, H. A., Wood, R., Plaut, M., Cooper, S. F., Fenton, M. J., Arshad, S., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.008 · Cited by 1,690
Self-citationPrevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents
Wagner, C. L., & Greer, F. R. (2008) · PEDIATRICS · doi:10.1542/peds.2008-1862 · Cited by 1,627
Agostoni, C. V., Buonocore, G., Carnielli, V. P., Curtis, M. D., Darmaun, D., Decsi, T., Domellöf, M., Embleton, N. D., Fusch, C., Genzel‐Boroviczény, O., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181adaee0 · Cited by 1,485
Research works printed but not linked: 1
- GRADEpro Guideline Development Tool (G2DT): Brożek J, Nowak A, Kunstman P, Schünemann HJ. (Computer Program) Version 2.xx. (Available from: www.guidelinedevelopment.org). In Book GRADEpro Guideline Development Tool (G2DT): Brożek J, Nowak A, Kunstman P, Schünemann HJ. (Computer Program) Version 2.xx. (Available from: www.guidelinedevelopment.org). (Editor ed.^eds.). City; 2014.
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Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634
Self-citationProbiotics, gut microbiota, and their influence on host health and disease
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600240 · Cited by 1,104
Bousquet, J., Antó, J. M., Bachert, C., Baiardini, I., Bosnic-Anticevich, S. Z., Canonica, G. W., Melén, E., Palomares, Ó., Scadding, G. K., Togias, A. G., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00227-0 · Cited by 1,018
Self-citationFood allergy: immune mechanisms, diagnosis and immunotherapy
Yu, W., Hussey, D. M., & Nadeau, K. C. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.111 · Cited by 676
Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 689
“Evidence from a meta-analysis supports the use of probiotics for the treatment of AD in infants; however, the benefit likely results from primary prevention of atopic dermatitis, as also concluded by the World Allergy Organization [114,196,197].”
Result
Metadata
- Authors
- Fiocchi, A., Pawankar, R., Cuello-Garcia, C., Ahn, K., Al-Hammadi, S., Agarwal, A., Beyer, K., Burks, W., Canonica, G. W., Ebisawa, M., Gandhi, S., Kamenwa, R., Lee, B. W., Li, H., Prescott, S., Riva, J. J., Rosenwasser, L., Sampson, H., Spigler, M., Terracciano, L., Vereda-Ortiz, A., Waserman, S., Yepes-Nuñez, J. J., Brożek, J. L., & Schünemann, H. J.
- Affiliations
- Bambino Gesù Children's Hospital (IT)
- Nippon Medical School (JP)
- Samsung Medical Center (KR)
- University of Toronto (CA)
- Stiftung Charité (DE)
- University of North Carolina at Chapel Hill (US)
- Ospedale Policlinico San Martino (IT)
- National Sagamihara Hospital (JP)
- Aga Khan University Hospital Nairobi (KE)
- National University of Singapore (SG)
- Children's Hospital of Chongqing Medical University (CN)
- The Kids Research Institute Australia (AU)
- McMaster University (CA)
- Children's Mercy Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
- Food Allergy Research and Education (US)
- University of Milan (IT)
- Hospital Infantil Universitario Niño Jesús (ES)
- Corresponding author
- Fiocchi, Alessandro
- Pawankar, Ruby
- Brożek, Jan L
- ORCID
- Venue
- World Allergy Organization Journal
- Publisher
- Elsevier BV
- Published
- 2015
- Volume
- 8
- Issue
- 1
- Pages
- 4
- ISSN
- 1939-4551 (ISSN-L)
- PMC
- PMC4307749
- OpenAlex
- W2141887889
- Cited by
- 473
- References
- 119
- Citations by year
- 2026: 6 · 2025: 23 · 2024: 40 · 2023: 43 · 2022: 36 · 2021: 45 · 2020: 54 · 2019: 48 · 2018: 47 · 2017: 45 · 2016: 56 · 2015: 29
- FWCI
- 78.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- World Allergy Organization Journal (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc-nd)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- TSpace (University of Toronto) (submittedVersion)
- eCommons - AKU (Aga Khan University) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- UNC Libraries
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- probiotics, allergy prevention, infants, eczema prevention, gut microbiota, probiotic supplementation, pregnancy, breastfeeding, high-risk infants, immunomodulation
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