Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model
Open accessAbstract
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the affected neuronal tissues. Histone acetylation is controlled by the antagonistic actions of two protein families -the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). Drugs inhibiting HDAC activity are already used in the clinic as anti-cancer agents. The aim of this study was to explore the therapeutic potential of HDAC inhibition in the context of ALS. We discovered that transgenic mice overexpressing wild-type FUS ("Tg FUS+/+"), which recapitulate many aspects of human ALS, showed reduced global histone acetylation and alterations in metabolic gene expression, resulting in a dysregulated metabolic homeostasis. Chronic treatment of Tg FUS+/+ mice with ACY-738, a potent HDAC inhibitor that can cross the blood-brain barrier, ameliorated the motor phenotype and substantially extended the life span of the Tg FUS+/+ mice. At the molecular level, ACY-738 restored global histone acetylation and metabolic gene expression, thereby re-establishing metabolite levels in the spinal cord. Taken together, our findings link epigenetic alterations to metabolic dysregulation in ALS pathology, and highlight ACY-738 as a potential therapeutic strategy to treat this devastating disease.
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Genetic knockdown and pharmacological inhibition of HDACs ameliorate ALS pathology in different ALS models.
“Notably, genetic knockdown and pharmacological inhibition of HDACs have been shown to ameliorate ALS pathology in different ALS models.341–344”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [341]
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- Authors
- Rossaert, E., Pollari, E., Jaspers, T., Van Helleputte, L., Jarpe, M., Van Damme, P., De Bock, K., Moisse, M., & Van Den Bosch, L.
- Affiliations
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Corresponding author
- Moisse, Matthieu
- Venue
- Acta Neuropathologica Communications
- Published
- 2019-07-05
- Volume
- 7
- Issue
- 1
- Pages
- 107-107
- ISSN
- 2051-5960 (ISSN-L)
- PMC
- PMC6612190
- OpenAlex
- W2955740693
- Cited by
- 93
- References
- 80
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 18 · 2023: 11 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 3
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Neuropathologica Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- Fund for Scientific Research Flanders (G.0431.12N and G.0440.12N)
- Interuniversity Attraction Poles Programme (P7/16)
- Muscular Dystrophy Association (577668)
- ALS Liga
- European Community's Health Seventh Framework Programme (FP7/2007-2013)
- ALS Therapy Alliance
- Amyotrophic Lateral Sclerosis Association (14-LGCA-181)
- Fondation Thierry Latran
- Opening the Future - KU Leuven
- Fonds Wetenschappelijk Onderzoek
- Een Hart voor ALS
- Laevers fund for ALS research
- Agentschap voor Innovatie door Wetenschap en Technologie
- Saastamoinen foundation
- Instrumentarium Science foundation
- Finnish Cultural foundation
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- amyotrophic lateral sclerosis, FUS, histone acetylation, histone deacetylase inhibition, epigenetic dysregulation, metabolic homeostasis, metabolic gene expression, motor phenotype, lifespan extension, spinal cord, neurodegeneration, transgenic mouse model
- MeSH terms
- Acetylation, Amyotrophic Lateral Sclerosis, Animals, Disease Models, Animal, Female, Histones, Humans, Hydroxamic Acids, Male, Mice, Transgenic, Pyrimidines, Random Allocation, RNA-Binding Protein FUS, Mice, Metabolomics, Histone Deacetylase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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