The DOI matches its Crossref record; 208 of the 210 references it cites were found in a registry or an index.
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence
Open accessAbstract
BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence induction. Recently, we determined the transcriptional changes combined with the transition into replicative senescence in primary human fibroblast strains. Here, by γ-irradiation we induced premature cellular senescence in the fibroblast cell strains (HFF and MRC-5) and determined the corresponding transcriptional changes by high-throughput RNA sequencing. RESULTS: Comparing the transcriptomes, we found a high degree of similarity in differential gene expression in replicative as well as in irradiation induced senescence for both cell strains suggesting, in each cell strain, a common cellular response to error accumulation. On the functional pathway level, "Cell cycle" was the only pathway commonly down-regulated in replicative and irradiation-induced senescence in both fibroblast strains, confirming the tight link between DNA repair and cell cycle regulation. However, "DNA repair" and "replication" pathways were down-regulated more strongly in fibroblasts undergoing replicative exhaustion. We also retrieved genes and pathways in each of the cell strains specific for irradiation induced senescence. CONCLUSION: We found the pathways associated with "DNA repair" and "replication" less stringently regulated in irradiation induced compared to replicative senescence. The strong regulation of these pathways in replicative senescence highlights the importance of replication errors for its induction.
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“These processes are commonly damaged in primary human fibroblast strains undergoing a cellular aging process as a consequence of finite proliferative capacity or oxidative stress [67]”
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Items 201–208 of 208
Kim, S. Y., Ryu, S. J., Kang, H. T., Choi, H. R., & Park, S. C. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0612-2 · Cited by 13
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Regulation of the Association between PSTPIP and CD2 in Murine T Cells
Bai, Y., Ding, Y., Spencer, S. D., Lasky, L. A., & Bromberg, J. S. (2001) · Experimental and Molecular Pathology · doi:10.1006/exmp.2001.2388 · Cited by 7
Unexpected Outcomes of CDK4/6 Inhibition
Choi, Y. J., & Siciński, P. (2013) · Oncotarget · doi:10.18632/oncotarget.912 · Cited by 7
Luo, P., Tresini, M., Cristofalo, V. J., Chen, X., Saulewicz, A. C., Gray, M. D., Banker, D. E., Klingelhutz, A. J., Ohtsubo, M., Takihara, Y., et al. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.11.030 · Cited by 5
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Skin Aging, Cellular Senescence and Natural Polyphenols
Csekes, E., & Račková, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312641 · Cited by 352
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 181
DePianto, D. J., Heiden, J. A. V., Morshead, K. B., Sun, K.-H., Modrusan, Z. D., Teng, G., Wolters, P. J., & Arron, J. R. (2021) · JCI Insight · doi:10.1172/jci.insight.143626 · Cited by 95
Short-term gain, long-term pain: the senescence life cycle and cancer
Chan, A. S. L., & Narita, M. (2019) · Genes & Development · doi:10.1101/gad.320937.118 · Cited by 80
Nagane, M., Kanai, E., Shibata, Y., Shimizu, T., Yoshioka, C., Maruo, T., & Yamashita, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195151 · Cited by 86
Metadata
- Authors
- Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S.
- Affiliations
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Corresponding author
- Marthandan, Shiva
- Venue
- Biological Research
- Published
- 2016-07-28
- Volume
- 49
- Issue
- 1
- Pages
- 34-34
- ISSN
- 0716-9760 (ISSN-L)
- 0717-6287
- PMC
- PMC4963952
- OpenAlex
- W2491783232
- Cited by
- 39
- References
- 210
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- Bundesministerium für Bildung und Forschung– BMBF (0315581)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- cellular senescence, replicative senescence, radiation-induced senescence, gamma irradiation, primary human fibroblasts, DNA repair, DNA replication, cell cycle regulation, transcriptome, differential gene expression, DNA damage accumulation, MRC-5 cells
- MeSH terms
- Analysis of Variance, beta-Galactosidase, Cells, Cultured, DNA Damage, DNA Repair, DNA Replication, Fibroblasts, Gamma Rays, Humans, Lung, Male, Time Factors, Immunoblotting, Down-Regulation, Up-Regulation, Cellular Senescence, Sequence Analysis, RNA, Gene Expression Profiling, Aborted Fetus
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