Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364

Differential expression analysis for sequence count data

Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581

TopHat: discovering splice junctions with RNA-Seq

Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Accurate whole human genome sequencing using reversible terminator chemistry

Bentley, D. R., Balasubramanian, S., Swerdlow, H. P., Smith, G. P., Milton, J., Brown, C. G., Hall, K. P., Evers, D. J., Barnes, C. L., Bignell, H. R., et al. (2008) · Nature · doi:10.1038/nature07517 · Cited by 3,684

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 1×

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070 · cited 2×

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986

Restoration of p53 function leads to tumour regression in vivo

Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00256-4 · Cited by 1,344 · cited 1×

GAGE: generally applicable gene set enrichment for pathway analysis

Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136

The emerging roles of forkhead box (Fox) proteins in cancer

Myatt, S. S., & Lam, E. W. ‐. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2223 · Cited by 1,077

The signals and pathways activating cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J. E., Premsrirut, P., Luo, W., Chicas, A., Lee, C. S., et al. (2011) · Genes & Development · doi:10.1101/gad.17276711 · Cited by 1,046

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019 · cited 1×

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., & Barrett, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13742 · Cited by 1,008

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903

Cellular senescence and its effector programs

Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855

Ensembl 2012

Flicek, P., Amode, M. R., Barrell, D. G., Beal, K. M., Brent, S., Carvalho‐Silva, D., Clapham, P., Coates, G. M. P., Fairley, S., Fitzgerald, S. F., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr991 · Cited by 842

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836

FoxM1 is required for execution of the mitotic programme and chromosome stability

Laoukili, J., Kooistra, M. R. H., Brás, A., Kauw, J. J. W., Kerkhoven, R. M., Morrison, A. J., Clevers, H. C., & Medema, R. H. (2005) · Nature Cell Biology · doi:10.1038/ncb1217 · Cited by 808

Microarray analysis of replicative senescence

Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., & Funk, W. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80420-5 · Cited by 764

Senescence and immortalization: role of telomeres and telomerase

Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 747

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data

Rapaport, F., Khanin, R., Liang, Y., Pirun, M., Krek, A., Zumbo, P., Mason, C. E., Socci, N. D., & Betel, D. (2013) · Genome Biology · doi:10.1186/gb-2013-14-9-r95 · Cited by 733

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

Finucane, D., Bossy‐Wetzel, E., Waterhouse, N. J., Cotter, T. G., & Green, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2225 · Cited by 714

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713

Cellular Mechanisms Controlling Caspase Activation and FunctionPreprint

Parrish, A. B., Freel, C. D., & Kornbluth, S. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008672 · Cited by 659

Untitled work

(2003) · PubMed · Cited by 608

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571

p16 INK4A is a robust in vivo biomarker of cellular aging in human skin

Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter‐Kochanek, K., Jansen‐Dürr, P., & Wlaschek, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00231.x · Cited by 557

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547

Untitled work

(1999) · PubMed · Cited by 546

A Conserved Regulatory System for Aging

Kenyon, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00306-3 · Cited by 529

DNA damage, cellular senescence and organismal ageing: causal or correlative?

Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 507

A negative feedback signaling network underlies oncogene-induced senescence

Courtois-Cox, S., Genther Williams, S. M., Reczek, E. E., Johnson, B. W., McGillicuddy, L. T., Johannessen, C. M., Hollstein, P. E., MacCollin, M., & Cichowski, K. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.003 · Cited by 501

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

Robles, S. J., & Adami, G. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201862 · Cited by 498

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

Wagner, W., Bork, S., Horn, P., Krunic, D., Walenda, T., Diehlmann, A., Beneš, V., Blake, J., Huber, F.-X., Eckstein, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005846 · Cited by 488

Different telomere damage signaling pathways in human and mouse cells

Smogorzewska, A., & de Lange, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf433 · Cited by 482 · cited 1×

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

Itahana, K., Zou, Y., Itahana, Y., Martinez, J.-L., Beausejour, C., Jacobs, J. J. L., van Lohuizen, M., Band, V., Campisi, J., & Dimri, G. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.389-401.2003 · Cited by 438

Comparison of software packages for detecting differential expression in RNA-seq studies

Seyednasrollah, F., Laiho, A., & Elo, L. L. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbt086 · Cited by 421

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development · doi:10.1101/gad.1487307 · Cited by 406

When cells get stressed: an integrative view of cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 ARF Tumor Suppressor

Dimri, G. P., Itahana, K., Acosta, M., & Campisi, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.273-285.2000 · Cited by 401

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.023 · Cited by 388

Cellular senescence: putting the paradoxes in perspective

Campisi, J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.005 · Cited by 368

Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressorPreprint

Kalinichenko, V. V., Major, M. L., Wang, X., Petrovic, V., Kuechle, J., Yoder, H. M., Dennewitz, M. B., Shin, B., Datta, A., Raychaudhuri, P., et al. (2004) · Genes & Development · doi:10.1101/gad.1200704 · Cited by 358

Loss of the Forkhead Transcription Factor FoxM1 Causes Centrosome Amplification and Mitotic Catastrophe

Wonsey, D. R., & Follettie, M. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4059 · Cited by 347

The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

Kim, I., Ackerson, T. J., Ramakrishna, S., Tretiakova, M., Wang, I., Kalin, T. V., Major, M. L., Gusarova, G. A., Yoder, H. M., Costa, R. H., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3003 · Cited by 338

PRAK Is Essential for ras-Induced Senescence and Tumor Suppression

Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.050 · Cited by 321

Cell senescence and cancer

Mathon, N. F., & Lloyd, A. C. (2001) · Nature reviews. Cancer · doi:10.1038/35106045 · Cited by 313

FOXM1, a typical proliferation-associated transcription factor

Wierstra, I., & Alves, J. (2007) · Biological Chemistry · doi:10.1515/bc.2007.159 · Cited by 313

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

Hara, E., Yamaguchi, T., Nojima, H., Ide, T., Campisi, J., Okayama, H., & Oda, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42146-6 · Cited by 311

Apoptosis and genomic instability

Zhivotovsky, B., & Kroemer, G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1443 · Cited by 310

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 8×

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.016 · Cited by 293

The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression

Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.146 · Cited by 276

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway

Debacq‐Chainiaux, F., Borlon, C., Pascal, T. G., Royer, V., Eliaers, F., Ninane, N., Carrard, G., Friguet, B., de Longueville, F., Boffe, S., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.01651 · Cited by 274

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

Hubackova, S., Krejcikova, K., Bartek, J., & Hodny, Z. (2012) · Aging · doi:10.18632/aging.100520 · Cited by 272

Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice

Kalin, T. V., Wang, I., Ackerson, T. J., Major, M. L., Detrisac, C. J., Kalinichenko, V. V., Lyubimov, A. V., & Costa, R. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3138 · Cited by 272

Bax-induced apoptotic cell death

Pawlowski, J. E., & Kraft, A. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.529 · Cited by 269

Chk2 Mediates Stabilization of the FoxM1 Transcription Factor To Stimulate Expression of DNA Repair Genes

Tan, Y., Raychaudhuri, P., & Costa, R. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01068-06 · Cited by 250

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

Millis, A. J. T., Hoyle, M., McCue, H. M., & Martini, H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90286-h · Cited by 245

Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine

Johansson, A.-C., Steen, H., Öllinger, K. M., & Roberg, K. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401290 · Cited by 234

Cell cycle regulation of human DNA repair and chromatin remodeling genes

Mjelle, R., Hegre, S. A., Aas, P. A., Slupphaug, G., Drabløs, F., Sætrom, P., & Krokan, H. E. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.03.007 · Cited by 216

CDC20, a potential cancer therapeutic target, is negatively regulated by p53

Kidokoro, T., Tanikawa, C., Furukawa, Y., Katagiri, T., Nakamura, Y., & Matsuda, K. (2007) · Oncogene · doi:10.1038/sj.onc.1210799 · Cited by 206

Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism

Kim, K. S., Seu, Y. B., Baek, S.-H., Kim, M. J., Kim, K. J., Kim, J. H., & Kim, J.-R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0280 · Cited by 199

The effect of age on cyclooxygenase-2 gene expression

Kim, H., Kim, K., Yu, B., & Chung, H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00274-9 · Cited by 199

DNA damage checkpoint kinase Chk2 triggers replicative senescence

Gire, V., Roux, P., Wynford‐Thomas, D., Brondello, J., & Dulic, V. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600259 · Cited by 198

Id Proteins

Ling, F., Kang, B., & Sun, X.-H. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-405943-6.00005-1 · Cited by 191

A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells

Smout, M. J., Laha, T., Mulvenna, J., Sripa, B., Suttiprapa, S., Jones, A., Brindley, P. J., & Loukas, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000611 · Cited by 187

Assessing cell and organ senescence biomarkers

de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187

p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.

Aliouat-Denis, C.-M., Dendouga, N., Van den Wyngaert, I., Goehlmann, H., Steller, U., van de Weyer, I., Van Slycken, N., Andries, L., Kass, S., Luyten, W., et al. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0121 · Cited by 177

Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening

Suzuki, K., Mori, I., Nakayama, Y., Miyakoda, M., Kodama, S., & Watanabe, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0248:rislga]2.0.co;2 · Cited by 177

Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

Kikuchi, N., Ishii, Y., Morishima, Y., Yageta, Y., Haraguchi, N., Itoh, K., Yamamoto, M. P., & Hizawa, N. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-31 · Cited by 176

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

Jia, L., Li, H., & Sun, Y. (2011) · Neoplasia · doi:10.1593/neo.11420 · Cited by 155

Senescence comes of age

Narita, M., & Lowe, S. W. (2005) · Nature Medicine · doi:10.1038/nm0905-920 · Cited by 153

Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth

Pazolli, E., Luo, X., Brehm, S., Carbery, K., Chung, J.-J., Prior, J. L., Doherty, J. M., Demehri, S., Salavaggione, L., Piwnica-Worms, D. R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2970 · Cited by 152

A genome-wide association study of aging

Walter, S., Atzmon, G., Demerath, E. W., Garcia, M. E., Kaplan, R. C., Meena Kumari, B., Lunetta, K. L., Milaneschi, Y., Tanaka, T., Tranah, G. J., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.026 · Cited by 151

Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis

Le, M., Gabai, V. L., & Sherman, M. Y. (2010) · Oncogene · doi:10.1038/onc.2010.277 · Cited by 148

Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer

Yi, J. M., Dhir, M., Neste, L. V., Downing, S. R., Jeschke, J., Glöckner, S. C., Calmon, M. F., Hooker, C. M., Funes, J. M., Boshoff, C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2509 · Cited by 145

p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation.

Linke, S. P., Clarkin, K., & Wahl, G. M. (1997) · PubMed · Cited by 143

Genome instability, cancer and aging

Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 134

Gene expression profiling of replicative and induced senescence

Purcell, M., Kruger, A., & Tainsky, M. A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.973327 · Cited by 132

Over‐expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis

Chan, D. W., Yu, S., Chiu, P., Yao, K., Liu, V., Cheung, A., & Ngan, H. (2008) · The Journal of Pathology · doi:10.1002/path.2355 · Cited by 131

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Baker, D. J., Weaver, R. L., & van Deursen, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.028 · Cited by 130

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescencePreprint

Aksoy, O., Chicas, A., Zeng, T., Zhao, Z., McCurrach, M. E., Wang, X., & Lowe, S. W. (2012) · Genes & Development · doi:10.1101/gad.196238.112 · Cited by 130

Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology

Yoon, I. K., Kim, H. K., Kim, W., Song, I., Kim, W., Kim, S., Baek, S.-H., Kim, J. H., & Kim, J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.07.002 · Cited by 128

Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

Mirzayans, R., Andrais, B., Scott, A., Wang, Y., & Murray, D. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122409 · Cited by 127

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

Xie, Z., Jay, K. A., Smith, D. L., Zhang, Y., Liu, Z., Zheng, J., Tian, R., Li, H., & Blackburn, E. H. (2015) · Cell · doi:10.1016/j.cell.2015.02.002 · Cited by 126

Cellular Senescence - its role in cancer and the response to ionizing radiation

Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 123

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.

Gopinathan, L., Tan, S. L. W., Padmakumar, V. C., Coppola, V., Tessarollo, L., & Kaldis, P. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3440 · Cited by 123

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts.

Dimri, G. P., Hara, E., & Campisi, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33990-x · Cited by 122

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

Androic, I., Krämer, A., Yan, R., Rödel, F., Gätje, R., Kaufmann, M., Strebhardt, K., & Yuan, J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-391 · Cited by 121

Roles of Chemokine Ligand-2 (CXCL2) and Neutrophils in Influencing Endothelial Cell Function and Inflammation of Human Adipose Tissue

Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D. (2013) · Endocrinology · doi:10.1210/en.2012-1415 · Cited by 119

Programs for Cell Death: Apoptosis is Only One Way to Go

Blank, M., & Shiloh, Y. (2007) · Cell Cycle · doi:10.4161/cc.6.6.3990 · Cited by 115

Implications of time-series gene expression profiles of replicative senescence.

Kim, Y., Byun, H., Jee, B. A., Cho, H., Seo, Y., Kim, Y., Park, M. H., Chung, H., Woo, H. G., & Yoon, G. (2013) · Aging Cell · doi:10.1111/acel.12087 · Cited by 106

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

Binet, R., Ythier, D., Robles, A. I., Collado, M., Larrieu, D., Fonti, C., Brambilla, E., Brambilla, C., Serrano, M., Harris, C. C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1016 · Cited by 101

Role of Cyclin B1 Levels in DNA Damage and DNA Damage-Induced Senescence

Nakayama, Y., & Yamaguchi, N. (2013) · International review of cytology · doi:10.1016/b978-0-12-407695-2.00007-x · Cited by 101

Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in Senescence

Johung, K. L., Goodwin, E. C., & DiMaio, D. (2006) · Journal of Virology · doi:10.1128/jvi.02348-06 · Cited by 100

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase‐9 in the absence of Apaf‐1

Manns, J., Daubrawa, M., Drießen, S., Paasch, F., Hoffmann, N. A., Löffler, A. S., Lauber, K., Dieterle, A. M., Alers, S., Iftner, T., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-177527 · Cited by 99

p53 negatively regulates expression of FoxM1

Pandit, B., Halasi, M., & Gartel, A. L. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9628 · Cited by 96

Human Cdc45 is a proliferation‐associated antigen

Pollok, S., Bauerschmidt, C., Saenger, J., Nasheuer, H., & Große, F. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05900.x · Cited by 91

Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq

Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91 · cited 17×

Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells

Kaistha, B. P., Honstein, T., Müller, V., Bielak, S., Sauer, M., Kreider, R., Fassan, M., Scarpa, A., Schmees, C., Volkmer, H., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.460 · Cited by 91

Deciphering the role of Nuclear Factor-κB in cellular senescence

Vaughan, S., & Jat, P. (2011) · Aging · doi:10.18632/aging.100390 · Cited by 90

Senescence-associated genes in normal human oral keratinocytes

Kang, M. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00061-2 · Cited by 89

Mechanisms of Action of DNA-Damaging Anticancer Drugs in Treatment of Carcinomas: Is Acute Apoptosis an “Off-Target” Effect?

Havelka, A. M., Berndtsson, M., Olofsson, A. M., Shoshan, M. C., & Linder, S. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707782110196 · Cited by 89

Deep Sequencing Reveals Novel MicroRNAs and Regulation of MicroRNA Expression during Cell Senescence

Dhahbi, J. M., Atamna, H., Boffelli, D., Magis, W., Spindler, S. R., & Martin, D. I. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020509 · Cited by 86

Nucleolar responses to DNA double-strand breaks

Larsen, D. H., & Stucki, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1312 · Cited by 84

ATF1 Phosphorylation by the ERK MAPK Pathway Is Required for Epidermal Growth Factor-induced c-jun Expression

Gupta, P., & Prywes, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209799200 · Cited by 83

PPARγ accelerates cellular senescence by inducing p16INK4α expression in human diploid fibroblasts

Gan, Q., Huang, J., Zhou, R., Niu, J., Zhu, X., Wang, J., Zhang, Z., & Tong, T. (2008) · Journal of Cell Science · doi:10.1242/jcs.026633 · Cited by 82

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

Lodygin, D., Menssen, A., & Hermeking, H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16588 · Cited by 80

Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment

Habert, M., Horn, J.-F., Sarazin, M., Lotterie, J.-A., Puel, M., Onen, F., Zanca, M., Portet, F., Touchon, J., Verny, M., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.01.013 · Cited by 75

A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.

Natarajan, E., Omobono, J. D., Guo, Z.-Y., Hopkinson, S., Lazar, A., Brenn, T., Jones, J. C. R., & Rheinwald, J. (2006) · American Journal of Pathology · doi:10.2353/ajpath.2006.051027 · Cited by 73

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

Kaneda, A., Fujita, T., Anai, M., Yamamoto, S., Nagae, G., Morikawa, M., Tsuji, S., Oshima, M., Miyazono, K., & Aburatani, H. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002359 · Cited by 72

The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit

Sivakumar, S., Daum, J. R., Tipton, A. R., Rankin, S., & Gorbsky, G. J. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0421 · Cited by 72

Reductions in serum IGF ‐1 during aging impair health span

Gong, Z., Kennedy, O. D., Sun, H., Wu, Y., Williams, G. A., Klein, L., Cardoso, L., Matheny, R. W., Hubbard, G. B., Ikeno, Y., et al. (2013) · Aging Cell · doi:10.1111/acel.12188 · Cited by 70

Mechanisms of staurosporine induced apoptosis in a human corneal endothelial cell line

Thuret, G. (2003) · British Journal of Ophthalmology · doi:10.1136/bjo.87.3.346 · Cited by 69

Expression profiles of schizophrenia susceptibility genes during human prefrontal cortical development

Choi, K. H., Zepp, M. E., Higgs, B. W., Weickert, C. S., & Webster, M. J. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0956 · Cited by 68

Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma

Zhang, L., Yang, Z., Ma, A., Qu, Y.-L., Xia, S., Xu, D., Ge, C., Qiu, B., Xia, Q., Li, J., et al. (2013) · Hepatology · doi:10.1002/hep.26628 · Cited by 67

Irradiation of Adult Human Dental Pulp Stem Cells Provokes Activation of p53, Cell Cycle Arrest, and Senescence but Not Apoptosis

Muthná, D., Soukup, T., Vávrová, J., Mokrý, J., Ćmielová, J., Víšek, B., Mrkvicová, A., Havelek, R., Suchánek, J., Filip, S., et al. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0449 · Cited by 66

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

Tomida, J., Takata, K., Lange, S. S., Schibler, A. C., Yousefzadeh, M. J., Bhetawal, S., Dent, S., & Wood, R. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1385 · Cited by 64

Smurf2‐mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence

Kong, Y., Cui, H., & Zhang, H. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00746.x · Cited by 62

Checkpoint signalling: focusing on 53BP1

Abraham, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb1202-e277 · Cited by 62

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

Sandhu, C., Donovan, J. C. H., Bhattacharya, N., Stampfer, M. R., Worland, P. J., & Slingerland, J. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203908 · Cited by 62

Decreased Gene Expression Responsible for Post-Ultraviolet DNA Repair Synthesis in Aging: A Possible Mechanism of Age-Related Reduction in DNA Repair Capacity

Takahashi, Y., Moriwaki, S., Sugiyama, Y., Endo, Y., Yamazaki, K., Mori, T., Takigawa, M., & Inoue, S. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23591.x · Cited by 61

Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts.

Musio, A., Montagna, C., Zambroni, D., Indino, E., Barbieri, O., Citti, L., VILLA, A. M., Ried, T., & Vezzoni, P. (2003) · PubMed · Cited by 61

Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro

Wu, Q., Liu, C., Tai, M., Liu, D., Lei, L., Wang, R., Tian, M., & Lü, Y. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.4 · Cited by 60

Oxidative stress--induced single-strand breaks in chromosomal telomeres of human retinal pigment epithelial cells in vitro.

Honda, S., Hjelmeland, L. M., & Handa, J. T. (2001) · PubMed · Cited by 57

Circulating cathepsin K as a potential novel biomarker of coronary artery disease

Cheng, X. W., Kikuchi, R., Ishii, H., Yoshikawa, D., Hu, L., Takahashi, R., Shibata, R., Ikeda, N., Kuzuya, M., Okumura, K., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.01.004 · Cited by 57

Long-Term Quiescent Fibroblast Cells Transit into Senescence

Marthandan, S., Priebe, S., Hemmerich, P. H., Klement, K., & Diekmann, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115597 · Cited by 55

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells

Nakamura, A., Redon, C. E., Bonner, W. M., & Sedelnikova, O. A. (2009) · Aging · doi:10.18632/aging.100019 · Cited by 54

Retinal and Nonocular Abnormalities in Cyp27a1Cyp46a1 Mice with Dysfunctional Metabolism of Cholesterol

Saadane, A., Mast, N., Charvet, C. D., Omarova, S., Zheng, W., Huang, S. S., Kern, T. S., Peachey, N. S., & Pikuleva, I. A. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.05.024 · Cited by 54

Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells

Lin, S., Yang, J., ELKAHLOUN, A. G., Bandyopadhyay, A. M., Wang, L., Cornell, J. E., Yeh, I., Agyin, J. K., Tomlinson, G. E., & Sun, L. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0849 · Cited by 52

Transcriptional Regulation of the p16 Tumor Suppressor Gene.

Kotake, Y., Naemura, M., Murasaki, C., Inoue, Y., & Okamoto, H. (2015) · PubMed · Cited by 51

Handbook of the Biology of Aging

Watt, D. F. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr108 · Cited by 49

Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines

Bunt, J., de Haas, T. G., Hasselt, N. E., Zwijnenburg, D. A., Köster, J., Versteeg, R., & Kool, M. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0546 · Cited by 48

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts

Marthandan, S., Priebe, S., Baumgart, M., Groth, M., Cellerino, A., Guthke, R., Hemmerich, P., & Diekmann, S. (2015) · BioMed Research International · doi:10.1155/2015/731938 · Cited by 47

A genomics approach identifies senescence‐specific gene expression regulation

Lackner, D. H., Hayashi, M. T., Cesare, A. J., & Karlseder, J. (2014) · Aging Cell · doi:10.1111/acel.12234 · Cited by 47 · cited 9×

Repairing DNA damage by XRCC6/KU70 reverses TLR4-deficiency-worsened HCC development via restoring senescence and autophagic flux

Wang, Z., Lin, H., Hua, F., & Hu, Z. (2013) · Autophagy · doi:10.4161/auto.24229 · Cited by 46

Replicative senescence and senescence-like state induced in cancer-derived cells

Hwang, E. S. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00102-1 · Cited by 45

Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin

Gavin, E. J., Song, B., Wang, Y., Xi, Y., & Ju, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004054 · Cited by 45

How Does Proliferative Homeostasis Change With Age? What Causes It and How Does It Contribute to Aging?

Campisi, J., & Sedivy, J. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln073 · Cited by 43

Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells

Chin, J. H., Okazaki, M., Frazier, J. S., Hu, Z., & Hoffman, B. B. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c362 · Cited by 43

TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented

Hirsch, L., Nazari, H. K., Sreekumar, P. G., Kannan, R., Dustin, L., Zhu, D., Barrón, E., & Hinton, D. R. (2014) · Cytokine · doi:10.1016/j.cyto.2014.11.014 · Cited by 43

Activation of Protein Kinase G Increases the Expression of p21CIP1, p27KIP1, and Histidine Triad Protein 1 through Sp1

Cen, B., Deguchi, A., & Weinstein, I. B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6869 · Cited by 40

The Genetics of Cellular Senescence

Bérubé, N. G., Smith, J. R., & Pereira‐Smith, O. M. (1998) · The American Journal of Human Genetics · doi:10.1086/301848 · Cited by 39

Overexpression of the Pituitary Tumor Transforming Gene Induces p53-dependent Senescence through Activating DNA Damage Response Pathway in Normal Human Fibroblasts

Hsu, Y.-H., Liao, L.-J., Yu, C.-H., Chiang, C., Jhan, J.-R., Chang, L.-C., Chen, Y.-J., Lou, P., & Lin, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096255 · Cited by 38

Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts

Schäuble, S., Klement, K., Marthandan, S., Münch, S., Heiland, I., Schuster, S., Hemmerich, P., & Diekmann, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042150 · Cited by 35

Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy

Ma, Y., Adjemian, S., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2014) · OncoImmunology · doi:10.4161/onci.27663 · Cited by 34

The Retinoblastoma Protein Selectively Represses E2F1 Targets via a TAAC DNA Element during Cellular Senescence

Chen, T., Xue, L., Niu, J., Ma, L., Li, N., Cao, X., Li, Q., Wang, M., Zhao, W., Li, G., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260679 · Cited by 34

WNT Signaling Suppression in the Senescent Human Thymus

Ferrando‐Martínez, S., Ruíz-Mateos, E., Dudakov, J. A., Velardi, E., Grillari, J., Kreil, D. P., Muñoz‐Fernández, M. Á., van den Brink, M. R. M., & Leal, M. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu030 · Cited by 34

Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G2 checkpoint arrest

Poehlmann, A., Habold, C., Walluscheck, D., Reißig, K., Bajbouj, K., Ullrich, O., Hartig, R., Gali‐Muhtasib, H. U., Diestel, A., Roessner, A., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01143.x · Cited by 33

Expression of cyclin A, B1 and D1 after induction of cell cycle arrest in the Jurkat cell line exposed to doxorubicin

Żuryń, A., Litwiniec, A., Gackowska, L., Pawlik, A., Grzanka, A. A., & Grzanka, A. (2012) · Cell Biology International · doi:10.1042/cbi20120274 · Cited by 32

Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21CIP1-dependent senescence

Iglesias–Ara, A., Zenarruzabeitia, O., Fernández‐Rueda, J., Sànchez‐Tilló, E., Field, S. J., Celada, A., & Zubiaga, A. M. (2010) · Oncogene · doi:10.1038/onc.2010.296 · Cited by 32

CDK2 Transcriptional Repression Is an Essential Effector in p53-Dependent Cellular Senescence—Implications for Therapeutic Intervention

Zalzali, H., Nasr, B., Harajly, M., Basma, H., Ghamloush, F., Ghayad, S. E., Ghanem, N., Evan, G. I., & Saab, R. H. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0163 · Cited by 32

The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers

Paulsen, M. T., Starks, A. M., Derheimer, F. A., Hanasoge, S., Li, L., Dixon, J. E., & Ljungman, M. E. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-25 · Cited by 32

Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis

Cosme‐Blanco, W., & Chang, S. S. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.03.011 · Cited by 31

Downregulation of Polo-Like Kinase 1 Induces Cellular Senescence in Human Primary Cells Through a p53-Dependent Pathway

Kim, H., Cho, J. H., & Kim, J.-R. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt017 · Cited by 30

IGFBP-3, a Marker of Cellular Senescence, Is Overexpressed in Human Papillomavirus-Immortalized Cervical Cells and Enhances IGF-1-Induced Mitogenesis

Baege, A. C., Disbrow, G. L., & Schlegel, R. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5720-5727.2004 · Cited by 30

DNA damage in healthy term neonate

Zhao, J., Liu, X., Ma, J.-W., & Zheng, R. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2004.02.003 · Cited by 30

Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas

Coppola, D., Balducci, L., Chen, D., Loboda, A. P., Nebozhyn, M., Staller, A., Fulp, W. J., Dalton, W. S., Yeatman, T. J., & Brem, S. S. (2014) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2014.08.003 · Cited by 29

The Transcription Factor Atf1 Binds and Activates the APC/C Ubiquitin Ligase in Fission Yeast

Ors, A., Grimaldi, M., Kimata, Y., Wilkinson, C. R. M., Jones, N., & Yamano, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018309 · Cited by 29

Liver X Receptor Alpha Associates With Human Life Span

Mooijaart, S. P., Kuningas, M., Westendorp, R. G. J., Houwing‐Duistermaat, J. J., Slagboom, P. E., Rensen, P. C. N., & van Heemst, D. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.343 · Cited by 28

Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress

Chen, J., & Ozanne, S. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.023 · Cited by 26

Hormetic effect of rotenone in primary human fibroblasts

Marthandan, S., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P. H., & Diekmann, S. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0038-8 · Cited by 26

Synergistic induction of intercellular adhesion molecule-1 by the human cytomegalovirus transactivators IE2p86 and pp71 is mediated via an Sp1-binding site

Kronschnabl, M., & Stamminger, T. (2003) · Journal of General Virology · doi:10.1099/vir.0.18703-0 · Cited by 26

Age-Associated Decline in cdk1 Activity Delays Cell Cycle Progression of Human T Lymphocytes

Quadri, R. A., Arbogast, A., Phelouzat, M.-A., Boutet, S. C., Plastre, O., & Proust, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5203 · Cited by 26

WI-38 senescence is associated with global and site-specific hypomethylation

Sidler, C. L., Wóycicki, R. K., Kovalchuk, I., & Kovalchuk, O. (2014) · Aging · doi:10.18632/aging.100679 · Cited by 24

Chronic kidney disease in older people with intellectual disability: Results of the HA-ID study

de Winter, C. F., Echteld, M. A., & Evenhuis, H. M. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.11.005 · Cited by 23

HLA-A and HLA-B transcription decrease with ageing in peripheral blood leucocytes

Morvan, C. L., Cogné, M., & Drouet, M. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01610.x · Cited by 23

Heat-Induced Proteasomic Degradation of HSF1 in Serum-Starved Human Fibroblasts Aging in Vitro

Bonelli, M. A., Alfieri, R. R., Poli, M., Petronini, P. G., & Borghetti, A. F. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5237 · Cited by 21

Age-Dependent Changes in DNA Repair in Radiation-Exposed Mice

Kovalchuk, I., Golubov, A., Koturbash, I. V., Kutanzi, K. R., Martin, O. A., & Kovalchuk, O. (2014) · Radiation Research · doi:10.1667/rr13697.1 · Cited by 21

Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells.

Carey, J. P. W., Knowell, A. E., Chinaranagari, S., & Chaudhary, J. (2013) · PubMed · Cited by 20

Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes

Harada, H., Nakagawa, H., Takaoka, M., Lee, J., Herlyn, M., Diehl, J. A., & Rustgi, A. K. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7043 · Cited by 20

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts

Dekker, P., Gunn, D. A., McBryan, T., Dirks, R. W., van Heemst, D., Lim, F.-L., Jochemsen, A. G., Vries, M. V., Nagel, J., Adams, P. D., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.06.002 · Cited by 17

Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence andIn VivoTissue Ageing

Voutetakis, K., Chatziioannou, A. A., Gonos, E. S., & Trougakos, I. P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/732914 · Cited by 17

Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes

Martin, N., Raguz, S., Dharmalingam, G., & Gil, J. (2013) · Cell Cycle · doi:10.4161/cc.25331 · Cited by 14

Age-related changes in the induction of DNA polymerases in rat liver by γ-ray irradiation

Kaneko, T., Tahara, S., Tanno, M., & Taguchi, T. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00119-7 · Cited by 14

Increased expression of oncogene-induced senescence markers during cervical squamous cell cancer development.

Zhang, Y., Guo, L., Xing, P., Chen, Y., Li, F., Zhu, W., & Lu, X. (2014) · Europe PMC (PubMed Central) · Cited by 14

Skin Aging, Cellular Senescence and Natural Polyphenols

Csekes, E., & Račková, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312641 · Cited by 352

Gene expression hallmarks of cellular ageing

Frenk, S., & Houseley, J. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 181

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

DePianto, D. J., Heiden, J. A. V., Morshead, K. B., Sun, K.-H., Modrusan, Z. D., Teng, G., Wolters, P. J., & Arron, J. R. (2021) · JCI Insight · doi:10.1172/jci.insight.143626 · Cited by 95

Short-term gain, long-term pain: the senescence life cycle and cancer

Chan, A. S. L., & Narita, M. (2019) · Genes & Development · doi:10.1101/gad.320937.118 · Cited by 80

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

Nagane, M., Kanai, E., Shibata, Y., Shimizu, T., Yoshioka, C., Maruo, T., & Yamashita, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195151 · Cited by 86

MOESM6 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Figshare · doi:10.6084/m9.figshare.c.3632300_d9

MOESM10 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P. H., Kaether, C., & Diekmann, S. (2016) · Figshare · doi:10.6084/m9.figshare.4427897

MOESM9 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Figshare · doi:10.6084/m9.figshare.c.3632300_d4

MOESM12 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Figshare · doi:10.6084/m9.figshare.c.3632300_d5

MOESM8 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P. H., Kaether, C., & Diekmann, S. (2016) · Figshare · doi:10.6084/m9.figshare.4427846