Cited by 944Gut microbiota and healthInflammatory Bowel DiseaseGastrointestinal motility and disorders

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Interaction between the gut microbiome and mucosal immune system

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Shi, Na, Li, Na, Duan, Xinwang, Niu, Haitao·2017·Military Medical Research

DOI 10.1186/s40779-017-0122-9PMC PMC5408367

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Abstract

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.

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An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554

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Ingala, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91820-6.16002-4 · Cited by 1
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Schieferecke, A. J., Ralph, N. K., & Schaffer, D. V. (2025) · Viruses · doi:10.3390/v17030414 · Cited by 2
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Chewning, S. S. (2018) · Cited by 1
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Hryn, V. H. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.02.058 · Cited by 1
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Nurgaziyev, M., Aitenov, Y., Khassenbekova, Z., Akpanova, S., Rysbekov, K., Kozhakhmetov, S., Nurgozhina, A., Sergazy, S. D., Chulenbayeva, L., OSPANOVA, Z., et al. (2020) · Biodiversitas Journal of Biological Diversity · doi:10.13057/biodiv/d211110 · Cited by 1
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Couloume, L., & Michel, L. (2021) · La Presse Médicale · doi:10.1016/j.lpm.2021.104072 · Cited by 2
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Darma, A., Azwin Mengindra Putera, Fitri, P., Alpha Fardah Athiyah, Ranuh, R. G., & Sudarmo, S. M. (2019) · Carpathian Journal of Food Science and Technology · doi:10.34302/crpjfst/2019.11.5.4 · Cited by 1
Modulação da microbiota intestinal na infância e suas interferências no sistema imunológico
Martins, L. D. E. D. S. (2022) · Research Society and Development · doi:10.33448/rsd-v11i9.32194 · Cited by 1
The Defense Response of the Innate Immune System: Influences of Food Components on the Early Phase of the Immune Response
Beermann, C. (2022) · Springer eBooks · doi:10.1007/978-3-031-11523-3_3 · Cited by 1
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Dièye, Y. (2022) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2022.17.002351 · Cited by 1
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Shen, L., Shen, Y. M., Zhu, Y., You, L., Zhang, Y., Su, Z., Peng, G., Deng, J., Zuo, Z., Zhong, Z., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2285062/v1 · Cited by 1
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Vaz, T. A. C. (2022) · doi:10.11606/d.11.2022.tde-06122022-172927 · Cited by 1
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Pérez-Pérez, L., Galisteo, C., Sanjuán, J. M. O., Cobo-Díaz, J. F., Puente, H., Rubio, P., Carvajal, A., & Argüello, H. (2025) · Research Square · doi:10.21203/rs.3.rs-5979918/v1 · Cited by 1
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Israel, A. O., Adetunji, C. O., Oyewole, O. A., Popoola, O. A., & Mathew, J. T. (2025) · doi:10.1002/9781394212699.ch11 · Cited by 1
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Dias, A. M. M. (2018) · theses.fr (ABES) · doi:10.70675/d23527b7z823fz490fzafeez21e0de6d2406 · Cited by 1
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da Silveira, D. M. M. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-06042018-152811
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Guzmán, E. A. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7185
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Arunima, A., Das, J. K., & Suar, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814468-8.00010-7
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Louis, L., & Weiner, D. B. (2019) · Current cancer research · doi:10.1007/978-3-030-04155-7_16
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Fields, C. T. (2022) · Digital Archive @ GSU · doi:10.57709/14866301
Microbiota development and mucosal IgA responses during childhood in health and allergic disease
Dzidic, M. (2019) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/125479
Die Abwehrreaktion des angeborenen Immunsystems: Einflüsse von Lebensmittelkomponenten auf die frühe Phase der Immunantwort
Beermann, C. (2019) · Springer eBooks · doi:10.1007/978-3-662-59119-2_3
Correlation between intestinal flora and gut immune system development
Wang, F., Yang, Z., Zhu, M.-J., Di, Z.-S., Shang, H.-W., & Xu, J.-D. (2019) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v27.i23.1446
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Hryn, V. H., Kostуlenko, Y. P., Shepitko, K. V., & Лавренко, Д. О. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.03.122
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Yong, Y., Kang, X., Yang, X., Hu, Y., Chen, R., Lin, X., Zhou, Y., Zhao, L., & Zhang, Y. (2020) · Research Square · doi:10.21203/rs.2.11014/v2
Tumour Necrosis Factor Signalling Heterogeneity in Inflammatory Bowel Diseases
Fenton, S. (2020) · Otago University Research Archive (University of Otago)

Authors: Shi, N., Li, N., Duan, X., & Niu, H.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Second Affiliated Hospital of Nanchang University (CN)
Corresponding author: Niu, Haitao
ORCID: Shi, Na
Li, Na
Duan, Xinwang
Niu, Haitao
Venue: Military Medical Research
Publisher: Elsevier BV
Published: 2017-04-27
Volume: 4
Issue: 1
Pages: 14-14
ISSN: 2054-9369 (ISSN-L)
DOI: 10.1186/s40779-017-0122-9
PMC: PMC5408367
OpenAlex: W2607879065
Cited by: 940
References: 98
Citations by year: 2026: 53 · 2025: 162 · 2024: 203 · 2023: 174 · 2022: 130 · 2021: 105 · 2020: 53 · 2019: 37 · 2018: 20 · 2017: 3
FWCI: 2.89
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Military Medical Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: CAMS Initiative for Innovative Medicine (2016-I2M-1-006)
"PUMC Distinguished Professorship" research grant from Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical Collage (PUMC),
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, mucosal immunity, intestinal homeostasis, dysbiosis, commensal microbiota, lamina propria, intestinal epithelial cells, intestinal inflammation, intestinal diseases, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Humans, Immunity, Innate, Intestines, Immunity, Mucosal, Microbial Interactions

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