Cited by 944Gut microbiota and healthInflammatory Bowel DiseaseGastrointestinal motility and disorders

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Interaction between the gut microbiome and mucosal immune system

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Shi, Na, Li, Na, Duan, Xinwang, Niu, Haitao·2017·Military Medical Research

DOI 10.1186/s40779-017-0122-9PMC PMC5408367

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Abstract

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.

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An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus
Arbuckle, M. R., McClain, M. T., Rubertone, M. V., Scofield, R. H., Dennis, G. J., James, J. A., & Harley, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021933 · Cited by 2,581
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?
Nasir, O. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350152 · Cited by 2,331
Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
Rantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323
Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus
AbuMaziad, A. S., Torrealba, J. R., Seikaly, M. G., Hassler, J. R., & Hendricks, A. R. (2017) · Case Reports in Nephrology and Dialysis · doi:10.1159/000475493 · Cited by 1,299
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285
Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,147
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060
Angiogenins: a new class of microbicidal proteins involved in innate immunity
Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 947
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S. G., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.003 · Cited by 833
Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
Seksik, P., Rigottier‐Gois, L., Gramet, G., BRIEND‐SUTREN, M., Pochart, P., Marteau, P. R., Jian, R., & Dore, J. M. (2003) · Gut · doi:10.1136/gut.52.2.237 · Cited by 746
The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses
Scott, M. G., Davidson, D. J., Gold, M. R., Bowdish, D. M. E., & Hancock, R. E. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3883 · Cited by 713
Wnt signalling induces maturation of Paneth cells in intestinal crypts
van Es, J. H., Jay, P., Gregorieff, A., van Gijn, M. E., Jonkheer, S. M., Hatzis, P., Thiele, A., van den Born, M., Begthel, H., Brabletz, T., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1240 · Cited by 679
Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells
Boismenu, R., & Havran, W. L. (1994) · Science · doi:10.1126/science.7973709 · Cited by 652
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647
Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus
Hevia, A., Milani, C., López, P., Cuervo, A., Arboleya, S., Duranti, S., Turroni, F., González, S., Suárez, A., Gueimonde, M., et al. (2014) · mBio · doi:10.1128/mbio.01548-14 · Cited by 632
CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut
Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., & Artis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.009 · Cited by 591
Differences between Tissue-Associated Intestinal Microfloras of Patients with Crohn's Disease and Ulcerative Colitis
Gophna, U., Sommerfeld, K., Gophna, S., Doolittle, W. F., & van Zanten, S. J. O. V. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01004-06 · Cited by 570
Fecal Microbiota in Premature Infants Prior to Necrotizing Enterocolitis
Mai, V., Young, C., Ukhanova, M., Wang, X., Sun, Y., Casella, G., Theriaque, D. W., Li, N., Sharma, R. R., Hudak, M. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020647 · Cited by 508
Self-citation
Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis
Costello, M., Ciccia, F., Willner, D. L., Warrington, N. M., Robinson, P. C., Gardiner, B., Marshall, M. S., Kenna, T., Triolo, G., & Brown, M. A. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38967 · Cited by 444
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
Longman, R., Diehl, G. E., Victorio, D., Huh, J. R., Galan, C., Miraldi, E. R., Swaminath, A., Bonneau, R., Scherl, E., & Littman, D. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140678 · Cited by 376
Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells
Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J.-P., & Sirard, J.-C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241308598 · Cited by 368
The Impact of the Level of the Intestinal Short Chain Fatty Acids in Inflammatory Bowel Disease Patients Versus Healthy Subjects
Faujan, N. H., Abdulamir, A. S., Fatimah, A. B., Anas, O. M., Shuhaimi, M., Yazid, A. M., & Loong, Y. Y. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010053 · Cited by 361
The microbiome and regulation of mucosal immunity
McDermott, A. J., & Huffnagle, G. B. (2013) · Immunology · doi:10.1111/imm.12231 · Cited by 351
Antibacterial membrane attack by a pore-forming intestinal C-type lectin
Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo, J., Grabe, M., Jiang, Q., et al. (2013) · Nature · doi:10.1038/nature12729 · Cited by 337
Peyer's patches: organizing B‐cell responses at the intestinal frontier
Reboldi, A., & Cyster, J. G. (2016) · Immunological Reviews · doi:10.1111/imr.12400 · Cited by 327
Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide
Bals, R., Weiner, D. J., Moscioni, A. D., Meegalla, R. L., & Wilson, J. M. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.6084-6089.1999 · Cited by 302
Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Muñoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R., Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090900 · Cited by 288
NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells.
Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · PubMed · Cited by 288
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.
Bandeira, A., Mota‐Santos, T. A., Itohara, S., Degermann, S., Heusser, C., Tonegawa, S., & Coutinho, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.1.239 · Cited by 283
The Normal Microbial Flora as a Major Stimulus for Proliferation of Plasma Cells Synthesizing IgA in the Gut
Crabbé, P. A., Bazin, H., Eyssen, H., & Heremans, J. F. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000230130 · Cited by 281
NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells
Awane, M., Andres, P. G., Li, D. J., & Reinecker, H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5337 · Cited by 272
Are the Two Human Papillomavirus Vaccines Really Similar? A Systematic Review of Available Evidence: Efficacy of the Two Vaccines against HPV
Mario, S. D., Basevi, V., Lopalco, P. L., Balduzzi, S., D’Amico, R., & Magrini, N. (2015) · Journal of Immunology Research · doi:10.1155/2015/435141 · Cited by 258
Impaired regulatory T cell function in germ‐free mice
Östman, S., Rask, C., Wold, A. E., Hultkrantz, S., & Telemo, E. (2006) · European Journal of Immunology · doi:10.1002/eji.200535244 · Cited by 257
Analysis of Fecal Lactobacillus Community Structure in Patients with Early Rheumatoid Arthritis
Liu, X., Zou, Q., Zeng, B., Fang, Y., & Wei, H. (2013) · Current Microbiology · doi:10.1007/s00284-013-0338-1 · Cited by 250
Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases
Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250
Porphyromonas gingivalis and disease‐related autoantibodies in individuals at increased risk of rheumatoid arthritis
Mikuls, T. R., Thiele, G. M., Deane, K. D., Payne, J. B., O’Dell, J. R., Yu, F. H. Z., Sayles, H. R., Weisman, M. H., Gregersen, P. K., Buckner, J. H., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34595 · Cited by 230
Recent Advances in Characterizing the Gastrointestinal Microbiome in Crohnʼs Disease
Wright, E. K., Kamm, M. A., Teo, S. M., Inouye, M., Wagner, J., & Kirkwood, C. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000382 · Cited by 219
Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study
Spehlmann, M. E., Begun, A. Z., Burghardt, J., Lepage, P., Raedler, A., & Schreiber, S. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20380 · Cited by 208
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells
Štëpánková, R., Powrie, F. M., Kofroňová, O., Kozáková, H., Hudcovic, T., Hrnčíř, T., Uhlig, H. H., Read, S., Šinkorová, Z., Benada, O., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20221 · Cited by 191
Microbiota and Mucosal Immunity in Amphibians
Colombo, B. M., Scalvenzi, T., Benlamara, S., & Pollet, N. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00111 · Cited by 171
Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota
Carasi, P., Racedo, S. M., Jacquot, C., Romanin, D. E., Serradell, M. A., & Urdaci, M. C. (2015) · Journal of Immunology Research · doi:10.1155/2015/361604 · Cited by 145
The Human Gut Microbiota
Harmsen, H. J. M., & de Goffau, M. C. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_7 · Cited by 137
Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease
Wang, Z.-K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14805 · Cited by 136
T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior to Manifest Germinal Center Formation
Bergqvist, P. J., Stensson, A., Lycke, N. Y., & Bemark, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901895 · Cited by 131
The role of Paneth cells and their antimicrobial peptides in innate host defense
Ayabe, T., Ashida, T., Kohgo, Y., & Kono, T. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.06.007 · Cited by 125
Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota
Stelter, C., Käppeli, R., König, C., Krah, A., Hardt, W., Stecher, B., & Bumann, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020749 · Cited by 123
Expression of pro‐inflammatory cytokines by TCRαβ+ T and TCRγδ+ T cells in an experimental model of colitis
Simpson, S. J., Holländer, G. A., Mizoguchi, E., Allen, D., Bhan, A. K., Wang, B., & Terhorst, C. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270104 · Cited by 118
Induction of gut IgA production through T cell‐dependent and T cell‐independent pathways
Bemark, M., Boysen, P., & Lycke, N. Y. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06378.x · Cited by 109
The Gut Microbiota in Inflammatory Bowel Disease
Macfarlane, G. T., Blackett, K. L., Nakayama, T., Steed, H., & Macfarlane, S. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168146 · Cited by 108
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Authors: Shi, N., Li, N., Duan, X., & Niu, H.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Second Affiliated Hospital of Nanchang University (CN)
Corresponding author: Niu, Haitao
ORCID: Shi, Na
Li, Na
Duan, Xinwang
Niu, Haitao
Venue: Military Medical Research
Publisher: Elsevier BV
Published: 2017-04-27
Volume: 4
Issue: 1
Pages: 14-14
ISSN: 2054-9369 (ISSN-L)
DOI: 10.1186/s40779-017-0122-9
PMC: PMC5408367
OpenAlex: W2607879065
Cited by: 940
References: 98
Citations by year: 2026: 53 · 2025: 162 · 2024: 203 · 2023: 174 · 2022: 130 · 2021: 105 · 2020: 53 · 2019: 37 · 2018: 20 · 2017: 3
FWCI: 2.89
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Military Medical Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: CAMS Initiative for Innovative Medicine (2016-I2M-1-006)
"PUMC Distinguished Professorship" research grant from Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical Collage (PUMC),
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, mucosal immunity, intestinal homeostasis, dysbiosis, commensal microbiota, lamina propria, intestinal epithelial cells, intestinal inflammation, intestinal diseases, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Humans, Immunity, Innate, Intestines, Immunity, Mucosal, Microbial Interactions

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