The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Interaction between the gut microbiome and mucosal immune system
Open accessAbstract
The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The gut microbiota and the gut immune system interact through the GBA to help maintain immune tolerance and shape the immune response during inflammation (89).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Cited by
Sorted by citations
Zhao, Z., Ning, J., Bao, X.-Q., Shang, M., Ma, J., Li, G., & Zhang, D. (2021) · Microbiome · doi:10.1186/s40168-021-01107-9 · Cited by 616
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Yoshii, K., Hosomi, K., Sawane, K., & Kunisawa, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00048 · Cited by 607
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529
Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease
Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445
Precision Nutrition and the Microbiome, Part I: Current State of the Science
Mills, S., Stanton, C., Lane, J. A., Smith, G., & Ross, R. P. (2019) · Nutrients · doi:10.3390/nu11040923 · Cited by 426
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Effects of Probiotics on Gut Microbiota: An Overview
Chandrasekaran, P., Weiskirchen, S., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116022 · Cited by 382
The Immunomodulatory Functions of Butyrate
Siddiqui, M. T., & Cresci, G. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300989 · Cited by 381
Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis
Fackelmann, G., & Sommer, S. (2019) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2019.04.030 · Cited by 399
Interactions between probiotics and pathogenic microorganisms in hosts and foods: A review
Mousavi Khaneghah, A., Abhari, K., Eş, I., Soares, M. B., Oliveira, R. B. A., Hosseini, H., Rezaei, M., Balthazar, C. F., Silva, R., Cruz, A. G., et al. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.11.022 · Cited by 275
Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270
Wang, X., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2023) · Microbiome · doi:10.1186/s40168-022-01452-3 · Cited by 273
Immunoregulatory role of the gut microbiota in inflammatory depression
Liu, P., Liu, Z., Wang, J., Wang, J., Gao, M., Zhang, Y., Yang, C., Zhang, A., Li, G., Li, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47273-w · Cited by 268
Microbiome and pathogen interaction with the immune system
Kogut, M. H., Lee, A., & Santín, E. (2020) · Poultry Science · doi:10.1016/j.psj.2019.12.011 · Cited by 266
Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G. E. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.05.015 · Cited by 251
Challenge to the Intestinal Mucosa During Sepsis
Haußner, F., Chakraborty, S., Halbgebauer, R., & Huber-Lang, M. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00891 · Cited by 233
Kouba, B. R., Borba, L. A., de Souza, P. B., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2024) · Cells · doi:10.3390/cells13050423 · Cited by 248
Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing
Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 202
The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
Bokoliya, S. C., Dorsett, Y., Panier, H. A., & Zhou, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.711055 · Cited by 194
Succinate metabolism and its regulation of host-microbe interactions
Wei, Y., Ma, X., Zhao, J., Wang, X., & Gao, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190300 · Cited by 204
Role of probiotics to combat viral infections with emphasis on COVID-19
Sundararaman, A., Ray, M., Veeranna, R. P., & Halami, P. M. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10832-4 · Cited by 186
Zhou, R., He, D., Xie, J., Zhou, Q., Zeng, H., Li, H., & Huang, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665901 · Cited by 191
New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries
Jain, T., Sharma, P., Are, A. C., Vickers, S. M., & Dudeja, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622064 · Cited by 187
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 197
Brown, R. M., Wiens, G. D., & Salinas, I. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.11.079 · Cited by 181
Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174
Xu, X., Lv, J., Guo, F., Li, J., Jia, Y., Jiang, D., Wang, N., Zhang, C., Kong, L., Liu, Y., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00814 · Cited by 173
The relationship between the gut microbiome and host gene expression: a review
Nichols, R. G., & Davenport, E. (2020) · Human Genetics · doi:10.1007/s00439-020-02237-0 · Cited by 177
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet
Lopez, D. E. G., Lashinger, L. M., Weinstock, G. M., & Bray, M. S. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.015 · Cited by 166
Vitamin D and the Host-Gut Microbiome: A Brief Overview
Akimbekov, N. S., Digel, I., Sherelkhan, D. K., Lutfor, A. B., & Razzaque, M. S. (2020) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.20011 · Cited by 153
Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health
Oerlemans, M. M. P., Akkerman, R., Ferrari, M. D. L., Walvoort, M. T. C., & de Vos, P. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104289 · Cited by 159
Probiotics for Parkinson’s Disease
Gazerani, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174121 · Cited by 156
Beyond the gut: decoding the gut–immune–brain axis in health and disease
Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149
The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 161
Secretome of Intestinal Bacilli: A Natural Guard against Pathologies
Ilinskaya, O. N., Владимировна, У. В., Рашидовна, Я. Д., & Гатауллин, И. Г. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01666 · Cited by 149
The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders
Maiuolo, J., Gliozzi, M., Musolino, V., Carresi, C., Scarano, F., Nucera, S., Scicchitano, M., Oppedisano, F., Bosco, F., Ruga, S., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.616883 · Cited by 153
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 151
Duan, Y., Huang, J., Sun, M., Jiang, Y., Wang, S., Wang, L., Yu, N., Peng, D., Wang, Y., Chen, W., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125953 · Cited by 143
The Role of Lipids in the Regulation of Immune Responses
Garcia, C., Andersen, C. J., & Blesso, C. N. (2023) · Nutrients · doi:10.3390/nu15183899 · Cited by 147
The gut microbiome-joint connection: implications in osteoarthritis
Favazzo, L. J., Hendesi, H., Villani, D. A., Soniwala, S., Dar, Q.-A., Schott, E. M., Gill, S. R., & Zuscik, M. J. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000681 · Cited by 141
Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy
Qiu, Q., Lin, Y., Ma, Y., Li, X., Liang, J. B., Chen, Z., Liu, K., Huang, Y., Luo, H., Huang, R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.612202 · Cited by 140
Intestinal microbiota and its interaction to intestinal health in nursery pigs
Duarte, M. E., & Kim, S. W. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.05.001 · Cited by 152
Role of Microbiota-Derived Extracellular Vesicles in Gut-Brain Communication
Cuesta, C. M., Guerri, C., Ureña, J., & Pascual, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084235 · Cited by 142
The gut ecosystem and immune tolerance
Shao, T., Hsu, R., Rafizadeh, D. L., Wang, L., Bowlus, C. L., Kumar, N., Mishra, J., Timilsina, S., Ridgway, W. M., Gershwin, M. E., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103114 · Cited by 143
Xi, F., Zhang, Z., Gao, W., Pan, Q., Luo, K., He, B., & Pu, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c05732 · Cited by 136
Honarpisheh, P., Reynolds, C. R., Conesa, M. P. B., Moruno-Manchon, J. F., Putluri, N., Bhattacharjee, M. B., Urayama, A., McCullough, L. D., & Ganesh, B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051711 · Cited by 129
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 129
The role of gut microbiota in intestinal disease: from an oxidative stress perspective
Sun, Y., Wang, X., Li, L., Zhong, C., Zhang, Y., Yang, X., Li, M., & Yang, C. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1328324 · Cited by 141
Bicknell, B. T., Liebert, A. D., Borody, T. J., Herkes, G., McLachlan, C. S., & Kiat, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119577 · Cited by 135
Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection
He, L., Ren, L., Li, J., Wu, Y.-N., Li, X., & Zhang, L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01388 · Cited by 135
The gut microbiota, environmental factors, and links to the development of food allergy
Lee, K. H., Song, Y., Wu, W., Yu, K., & Zhang, G. (2020) · Clinical and Molecular Allergy · doi:10.1186/s12948-020-00120-x · Cited by 126
Live Biotherapeutic Products, A Road Map for Safety Assessment
Rouanet, A., Bolca, S., Bru, A., Claes, I., Cvejic, H., Girgis, H., Harper, A., Lavergne, S. N., Mathys, S., Pane, M., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00237 · Cited by 120
Chen, S., Yong, Y., & Ju, X. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.103019 · Cited by 120
Ouyang, Y., Zhao, J., & Wang, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.032 · Cited by 120
Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue
Song, Z., Song, R., Liu, Y., Wu, Z., & Zhang, X. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112730 · Cited by 136
Immune-checkpoint inhibitor resistance in cancer treatment: Current progress and future directions
Zhang, C., Zhang, C., & Wang, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216182 · Cited by 125
Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer
Temraz, S. N., Nassar, F. J., Nasr, R., Charafeddine, M., Mukherji, D., & Shamseddine, A. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174155 · Cited by 125
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer
Suarez-Martinez, E., Suazo-Sanchez, I., Celis-Romero, M., & Carnero, A. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00775-w · Cited by 118
Zuppi, M., Hendrickson, H. L., O'Sullivan, J. M., & Vatanen, T. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.822562 · Cited by 124
Gut microbial-derived short-chain fatty acids and bone: a potential role in fracture healing
Wallimann, A., Magrath, W. J., Thompson, K., Moriarty, T. F., Richards, R. G., Akdiş, C. A., O’Mahony, L., & Hernandez, C. J. (2021) · European Cells and Materials · doi:10.22203/ecm.v041a29 · Cited by 112
Dietary nutrition and gut microflora: A promising target for treating diseases
Nie, Y., Luo, F., & Lin, Q. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.03.002 · Cited by 106
Sansores‐España, L. D., Melgar‐Rodríguez, S., Sagredo-Olivares, K., Cafferata, E. A., Martínez-Aguilar, V. M., Vernal, R., Paula-Lima, A. C., & Díaz‐Zúñiga, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.781582 · Cited by 110
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis
Tan, C., Yan, Q., Ma, Y., Fang, J., & Yang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1015175 · Cited by 120
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101
Eilam, Y., Khattib, H., Pintel, N., & Avni, D. (2023) · Global Challenges · doi:10.1002/gch2.202200177 · Cited by 101
Association between the gut and oral microbiome with obesity
Benahmed, A. G., Gasmi, A., Doşa, A., Chirumbolo, S., Mujawdiya, P. K., Aaseth, J., Dadar, M., & Bjørklund, G. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102248 · Cited by 102
Ischemic stroke and intestinal flora: an insight into brain–gut axis
Hu, W., Kong, X., Wang, H., Li, Y., & Luo, Y. (2022) · European journal of medical research · doi:10.1186/s40001-022-00691-2 · Cited by 102
The gut microbiota–brain axis in neurological disorders
You, M., Chen, N., Yang, Y., Cheng, L., He, H., Cai, Y., Liu, Y., Liu, H., & Hong, G. (2024) · MedComm · doi:10.1002/mco2.656 · Cited by 113
Epigenetics in depression and gut-brain axis: A molecular crosstalk
Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 102
Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases
Ferreira, C., Vieira, P., Sá, H., Malva, J. O., Castelo-Branco, M. S., Reis, F., & Viana, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1360065 · Cited by 110
Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System
Kotla, N. G., Isa, I. L. M., Rasala, S., Demir, S., Singh, R., Baby, B. V., Swamy, S. K., Dockery, P., Jala, V. R., Rochev, Y. A., et al. (2021) · Advanced Science · doi:10.1002/advs.202103189 · Cited by 96
Wang, Y. N., Tao, H., Huang, H., Xiao, Y., Wu, X., Li, M., Shen, J., Xiao, Z., Zhao, Y., Du, F., et al. (2021) · Food & Function · doi:10.1039/d0fo03061a · Cited by 95
Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review
Durkin, L., Childs, C. E., & Calder, P. C. (2021) · Foods · doi:10.3390/foods10010199 · Cited by 94
Possible role of gut microbes and host's immune response in gut-lung homeostasis
Rastogi, S., Mohanty, S., Sharma, S., & Tripathi, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954339 · Cited by 94
The emerging role of the small intestinal microbiota in human health and disease
Ruigrok, R. A. A. A., Weersma, R. K., & Vila, A. V. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2201155 · Cited by 101
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Dourado, E., Ferro, M., Guerreiro, C. S., & Fonseca, J. E. (2020) · Nutrients · doi:10.3390/nu12113504 · Cited by 95
Yang, Y., Wang, Y., Zhao, L., Wang, F., Li, M., Wang, Q., Luo, H., Zhao, Q., Zeng, J., Zhao, Y., et al. (2023) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.03.003 · Cited by 94
Neuro-immune regulation of mucosal physiology
Chesné, J., Cardoso, V., & Veiga‐Fernandes, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0063-y · Cited by 94
Gupta, N., Kumar, R. K., & Agrawal, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00709 · Cited by 91
Song, B., He, J., Pan, X., Kong, L., Xiao, C., Keerqin, C., & Song, Z. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00916-2 · Cited by 95
Sławińska, A., Dunisławska, A., Płowiec, A., Radomska, M., Lachmanska, J., Siwek, M. Z., Tavaniello, S., & Maiorano, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212318 · Cited by 95
Zhang, K.-K., Chen, L., Yang, J.-Z., Liu, J., Li, J.-H., Liu, Y., Li, X., Chen, L., Hsu, C., Zeng, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.010 · Cited by 90
The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective
Wang, L., Cao, Z.-M., Zhang, L., Li, J.-M., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923599 · Cited by 89
Xiang, X., Zheng, H., Wang, R., Chen, H., Xiao, J., Zheng, B., Liu, S., & Ding, Y. (2021) · Marine Drugs · doi:10.3390/md19080456 · Cited by 84
Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?
Li, W., Lai, K., Chopra, N., Zheng, Z., Das, A., & Diwan, A. D. (2022) · European Spine Journal · doi:10.1007/s00586-022-07152-8 · Cited by 87
The Impact of Food Additives on the Abundance and Composition of Gut Microbiota
Zhou, X., Qiao, K., Wu, H., & Zhang, Y. (2023) · Molecules · doi:10.3390/molecules28020631 · Cited by 95
Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T. (2020) · Aging · doi:10.18632/aging.102690 · Cited by 82
Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke
Xie, X., Wang, L., Dong, S., Ge, S., & Zhu, T. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380869 · Cited by 87
Tsao, S.-P., Nurrahma, B. A., Kumar, R., Wu, C.-H., Yeh, T.-H., Chiu, C.-C., Lee, Y.-P., Liao, Y.-C., Huang, C.-H., Yeh, Y.-T., et al. (2021) · Antioxidants · doi:10.3390/antiox10111823 · Cited by 79
Cannarella, L. A. T., Mari, N. L., de Alcantara, C. C., Iryioda, T. M. V., Costa, N. T., Oliveira, S. R., Lozovoy, M. A. B., Reiche, E. M. V., Dichi, I., & Simão, A. N. C. (2021) · Nutrition · doi:10.1016/j.nut.2021.111282 · Cited by 79
The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept
Sharon, I., Quijada, N. M., Pasolli, E., Fabbrini, M., Vitali, F., Agamennone, V., Dötsch, A., Selberherr, E., Grau, J. H., Meixner, M., et al. (2022) · Nutrients · doi:10.3390/nu14142872 · Cited by 83
Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?
Kraft, S., Buchenauer, L., & Polte, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212269 · Cited by 82
Mandrioli, J., Amedei, A., Cammarota, G., Niccolai, E., Zucchi, E., D’Amico, R., Ricci, F., Quaranta, G., Spanu, T., & Masucci, L. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01021 · Cited by 81
Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies
Lu, Q., Liang, Y., Tian, S., Jin, J., Zhao, Y., & Fan, H. (2023) · Toxics · doi:10.3390/toxics11121011 · Cited by 86
Kumar, M., Garand, M., & Khodor, S. A. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02174-1 · Cited by 81
Vaccine Strategies to Elicit Mucosal Immunity
Song, Y., Mehl, F., & Zeichner, S. L. (2024) · Vaccines · doi:10.3390/vaccines12020191 · Cited by 87
Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics
Ferenc, K., Sokal-Dembowska, A., Helma, K., Motyka, E., Jarmakiewicz-Czaja, S., & Filip, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021228 · Cited by 80
Metadata
- Authors
- Shi, N., Li, N., Duan, X., & Niu, H.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Corresponding author
- Niu, Haitao
- Venue
- Military Medical Research
- Publisher
- Elsevier BV
- Published
- 2017-04-27
- Volume
- 4
- Issue
- 1
- Pages
- 14-14
- ISSN
- 2054-9369 (ISSN-L)
- PMC
- PMC5408367
- OpenAlex
- W2607879065
- Cited by
- 940
- References
- 98
- Citations by year
- 2026: 53 · 2025: 162 · 2024: 203 · 2023: 174 · 2022: 130 · 2021: 105 · 2020: 53 · 2019: 37 · 2018: 20 · 2017: 3
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Military Medical Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- CAMS Initiative for Innovative Medicine (2016-I2M-1-006)
- "PUMC Distinguished Professorship" research grant from Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical Collage (PUMC),
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, mucosal immunity, intestinal homeostasis, dysbiosis, commensal microbiota, lamina propria, intestinal epithelial cells, intestinal inflammation, intestinal diseases, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Humans, Immunity, Innate, Intestines, Immunity, Mucosal, Microbial Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
