Cited by 229Iron Metabolism and DisordersTuberculosis Research and EpidemiologyAntimicrobial Peptides and Activities

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Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Sow, Fatoumata B, Florence, William C, Satoskar, Abhay R, Schlesinger, Larry S, Zwilling, Bruce S, Lafuse, William P·2007·Journal of Leukocyte Biology

DOI 10.1189/jlb.0407216

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Abstract

Hepcidin is an antimicrobial peptide produced by the liver in response to inflammatory stimuli and iron overload. Hepcidin regulates iron homeostasis by mediating the degradation of the iron export protein ferroportin 1, thereby inhibiting iron absorption from the small intestine and release of iron from macrophages. Here, we examined the expression of hepcidin in macrophages infected with the intracellular pathogens Mycobacterium avium and Mycobacterium tuberculosis. Stimulation of the mouse RAW264.7 macrophage cell line and mouse bone marrow-derived macrophages with mycobacteria and IFN-γ synergistically induced high levels of hepcidin mRNA and protein. Similar results were obtained using the human THP-1 monocytic cell line. Stimulation of macrophages with the inflammatory cytokines IL-6 and IL-β did not induce hepcidin mRNA expression. Iron loading inhibited hepcidin mRNA expression induced by IFN-γ and M. avium, and iron chelation increased hepcidin mRNA expression. Intracellular protein levels and secretion of hepcidin were determined by a competitive chemiluminescence ELISA. Stimulation of RAW264.7 cells with IFN-γ and M. tuberculosis induced intracellular expression and secretion of hepcidin. Furthermore, confocal microscopy analyses showed that hepcidin localized to the mycobacteria-containing phagosomes. As hepcidin has been shown to possess direct antimicrobial activity, we investigated its activity against M. tuberculosis. We found that hepcidin inhibited M. tuberculosis growth in vitro and caused structural damage to the mycobacteria. In summary, our data show for the first time that hepcidin localizes to the phagosome of infected, IFN-γ-activated cells and has antimycobacterial activity.

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Authors: Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P.
Affiliations: The Ohio State University (US)
Corresponding author: Lafuse, William P
ORCID: Sow, Fatoumata B
Satoskar, Abhay R
Schlesinger, Larry S
Lafuse, William P
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2007-07-03
Volume: 82
Issue: 4
Pages: 934-945
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0407216
OpenAlex: W2107072141
Cited by: 229
References: 52
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 18 · 2012: 13
FWCI: 9.16
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (RO1DK-57667)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: hepcidin, macrophages, tuberculosis, Mycobacterium tuberculosis, Mycobacterium avium, iron homeostasis, ferroportin 1, interferon-gamma, antimicrobial activity, phagosome, host defense, iron chelation, iron loading
MeSH terms: Animals, Cell Line, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Interferon-gamma, Intestinal Absorption, Iron, Iron Chelating Agents, Liver, Mycobacterium avium, Mycobacterium tuberculosis, Phagosomes, RNA, Messenger, Tuberculosis, Iron Overload, Antimicrobial Cationic Peptides, Mice, Hepcidins

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Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

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