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Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge
Abstract
Human MSCs may respond to TLR ligation, and recent research has suggested that many tissues contain tissue-specific MSCs, possibly located in periendothelial and perivascular regions. At present, the functional consequences of these findings are unclear. We hypothesized that tissue-specific MSCs could play an instructional role during early phases of bacterial challenge. To investigate this hypothesis further, we set up a coculture system of glandular MSCs and peripheral blood neutrophils so that we could analyze the cellular interactions of these cells in response to LPS challenge. We found that stimulation with bacterial endotoxin induced chemokine receptor expression and mobility of MSCs. Activated MSCs secreted large amounts of inflammatory cytokines and recruited neutrophils in an IL-8- and MIF-dependent manner. Recruited and activated neutrophils showed a prolonged lifespan, an increased expression of inflammatory chemokines, and an enhanced responsiveness toward subsequent challenge with LPS. Our findings demonstrate a complex, functional interaction between tissue-resident MSCs and peripheral blood neutrophils upon bacterial challenge and suggest a role for MSCs in the early phases of pathogen challenge, when classical immune cells have not been recruited yet.
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“MSCs also secrete CXCL8 (also known as IL-8) and macrophage migration inhibitory factor (MIF), known for recruiting neutrophils into the injured site [42], [64].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [64]
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Metadata
- Authors
- Brandau, S., Jakob, M., Hemeda, H., Bruderek, K., Janeschik, S., Bootz, F., & Lang, S.
- Affiliations
- Essen University Hospital (DE)
- University Hospital Bonn (DE)
- Corresponding author
- Brandau, Sven
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-03
- Volume
- 88
- Issue
- 5
- Pages
- 1005-1015
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2112271653
- Cited by
- 155
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 11 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 10
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Else-Kröner Fresenius Stiftung
- German Israeli Foundation
- Bartling Stiftung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophils, bacterial endotoxin, lipopolysaccharide, interleukin-8, macrophage migration inhibitory factor, chemokine receptor expression, neutrophil recruitment, inflammatory cytokines, neutrophil lifespan, innate immunity
- MeSH terms
- Bacterial Infections, Cell Movement, Chemotaxis, Leukocyte, Flow Cytometry, Humans, Inflammation, Lipopolysaccharides, Lymphocyte Activation, Neutrophils, Parotid Gland, Salivary Gland Diseases, T-Lymphocytes, Cytokines, Receptors, Chemokine, Reverse Transcriptase Polymerase Chain Reaction, Mesenchymal Stem Cells
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