The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
Abstract
Defensins, a family of cationic, structurally related, antimicrobial peptides, contribute to host defense by disrupting the cytoplasmic membrane of microbes. Here we show that human neutrophil defensins selectively induce the migration of human CD4+/CD45RA+ naive and CD8+, but not CD4+/CD45RO+ memory, T cells. Moreover, human neutrophil defensins are chemotactic for immature human dendritic cells derived from either CD34+ progenitors or peripheral blood monocytes. Upon maturation induced by treatment with tumor necrosis factor α (TNF-α), dendritic cells lose their responsiveness to human neutrophil defensins. The chemotactic effect of human neutrophil defensins on both T and dendritic cells is pertussis toxin-sensitive, suggesting that a Giα protein-coupled receptor is responsible. Human neutrophil defensins are also chemotactic for immature murine dendritic cells. These data suggest that, in addition to their antimicrobial role, human neutrophil defensins also contribute to adaptive immunity by mobilizing T cells and dendritic cells.
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Citations
Cites
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Self-citationCallan, M. F. C., Tan, L., Annels, N., Ogg, G. S., Wilson, J. D. K., O'Callaghan, C. A., Steven, N., McMichael, A. J., & Rickinson, A. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1395 · Cited by 892
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,313
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Mammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
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Metadata
- Authors
- Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 68
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2165998893
- Cited by
- 501
- References
- 2
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000). Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.68.1.9
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