Cited by 228Phytochemicals and Medicinal PlantsParkinson's Disease Mechanisms and TreatmentsMedicinal Plants and Neuroprotection

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Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

Ahmad, Muzamil, Saleem, Sofiyan, Ahmad, Abdullah Shafique, Ansari, Mubeen Ahmad, Yousuf, Seema, Hoda, Md Nasrul, Islam, Fakhrul·2005·Human & Experimental Toxicology

DOI 10.1191/0960327105ht509oa

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Abstract

6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenching properties in various diseased conditions. Rats were pretreated with 100, 200 and 300 mg/kg b.w. of the W. somnifera extract orally for 3 weeks. On day 21, 2 microL of 6-OHDA (10 microg in 0.1% in ascorbic acid-saline) was infused into the right striatum while sham operated group received 2 microL of the vehicle. Three weeks after 6-OHDA injections, rats were tested for neurobehavioral activity and were killed 5 weeks after lesioning for the estimation of lipidperoxidation, reduced glutathione content, activities of glutathione-S-transferase, glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase, catecholamine content, dopaminergic D2 receptor binding and tyrosine hydroxylase expression. W. somnifera extract was found to reverse all the parameters significantly in a dose-dependent manner. Thus, the study demonstrates that the extract of W. somnifera may be helpful in protecting the neuronal injury in Parkinson's disease.

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Authors: Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F.
Affiliations: Jamia Hamdard (IN)
Corresponding author: Islam, Fakhrul
ORCID: Ahmad, Muzamil
Ahmad, Abdullah Shafique
Ansari, Mubeen Ahmad
Yousuf, Seema
Islam, Fakhrul
Venue: Human & Experimental Toxicology
Publisher: SAGE Publications
Published: 2005-03
Volume: 24
Issue: 3
Pages: 137-147
ISSN: 0960-3271 (ISSN-L)
1477-0903
DOI: 10.1191/0960327105ht509oa
OpenAlex: W1977817564
Cited by: 227
References: 51
Citations by year: 2026: 5 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 14 · 2013: 17 · 2012: 13
FWCI: 12.05
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Human & Experimental Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: Withania somnifera, ashwagandha extract, Parkinson's disease, 6-hydroxydopamine, neuroprotection, oxidative stress, striatum, antioxidant enzymes, lipid peroxidation, dopaminergic neurons, tyrosine hydroxylase, D2 receptor binding, catecholamines
MeSH terms: Animals, Behavior, Animal, Brain, Disease Models, Animal, Male, Plant Extracts, Oxidopamine, Rats, Wistar, Neuroprotective Agents, Parkinsonian Disorders, Withania, Rats

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Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

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