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Cited by 228Phytochemicals and Medicinal PlantsParkinson's Disease Mechanisms and TreatmentsMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

Ahmad, Muzamil, Saleem, Sofiyan, Ahmad, Abdullah Shafique, Ansari, Mubeen Ahmad, Yousuf, Seema, Hoda, Md Nasrul, Islam, Fakhrul·2005·Human & Experimental Toxicology
DOI 10.1191/0960327105ht509oa
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Abstract

6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenching properties in various diseased conditions. Rats were pretreated with 100, 200 and 300 mg/kg b.w. of the W. somnifera extract orally for 3 weeks. On day 21, 2 microL of 6-OHDA (10 microg in 0.1% in ascorbic acid-saline) was infused into the right striatum while sham operated group received 2 microL of the vehicle. Three weeks after 6-OHDA injections, rats were tested for neurobehavioral activity and were killed 5 weeks after lesioning for the estimation of lipidperoxidation, reduced glutathione content, activities of glutathione-S-transferase, glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase, catecholamine content, dopaminergic D2 receptor binding and tyrosine hydroxylase expression. W. somnifera extract was found to reverse all the parameters significantly in a dose-dependent manner. Thus, the study demonstrates that the extract of W. somnifera may be helpful in protecting the neuronal injury in Parkinson's disease.

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Research works printed but not linked: 4

  1. Mishra LC, 2000, Alternive Medicine Reviews, 5, 334
  2. Panda S, 1997, Indian Journal of Physiology Pharmacology, 41, 424
  3. Mohandas J, 1984, Cancer Research, 44, 5086
  4. Cohen G, 1984, Neurotoxicology, 5, 77

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Metadata

Authors
Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F.
Affiliations
Jamia Hamdard (IN)
Corresponding author
Islam, Fakhrul
ORCID
Venue
Human & Experimental Toxicology
Publisher
SAGE Publications
Published
2005-03
Volume
24
Issue
3
Pages
137-147
ISSN
  • 0960-3271 (ISSN-L)
  • 1477-0903
DOI
10.1191/0960327105ht509oa
OpenAlex
W1977817564
Cited by
227
References
51
Citations by year
2026: 5 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 14 · 2013: 17 · 2012: 13
FWCI
12.05
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Human & Experimental Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Withania somnifera, ashwagandha extract, Parkinson's disease, 6-hydroxydopamine, neuroprotection, oxidative stress, striatum, antioxidant enzymes, lipid peroxidation, dopaminergic neurons, tyrosine hydroxylase, D2 receptor binding, catecholamines
MeSH terms
Animals, Behavior, Animal, Brain, Disease Models, Animal, Male, Plant Extracts, Oxidopamine, Rats, Wistar, Neuroprotective Agents, Parkinsonian Disorders, Withania, Rats

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