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Cited by 367

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Disulfiram Treatment of Alcoholism

Chick, Jonathan, Gough, Kevin, Falkowski, Wojciech, Kershaw, Peter, Hore, Brian, Mehta, Brij, Ritson, Bruce, Ropner, Richard, Torley, Denis·1992·British Journal of Psychiatry
DOI 10.1192/bjp.161.1.84
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Abstract

To assess the efficacy of supervised disulfiram as an adjunct to out-patient treatment of alcoholics, a randomised, partially blind, six-month follow-up study was conducted in which 126 patients received 200 mg disulfiram or 100 mg vitamin C under the supervision of a nominated informant. In the opinion of the (blinded) independent assessor, patients on disulfiram increased average total abstinent days by 100 and patients on vitamin C by 69, thus enhancing by one-third this measure of treatment outcome. Mean weekly alcohol consumption was reduced by 162 units with disulfiram, compared with 105 units with vitamin C., and the disulfiram patients reduced their total six-month alcohol consumption by 2572 units compared with an average reduction of 1448 units in the vitamin C group. Serum gamma-GT showed a mean fall of 21 IU/I in patients on disulfiram but rose by a mean of 13 IU/I with vitamin C. Unwanted effects in the disulfiram group led to a dose reduction in seven patients and to treatment withdrawal in four (and in one vitamin C patient). Two-thirds of the disulfiram group asked to continue the treatment at the end of the study. There were no medically serious adverse reactions.

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Research works printed but not linked: 20

  1. 10.1111/j.1530-0277.1988.tb00180.x · DOI
  2. 10.7326/0003-4819-90-6-901 · DOI · Paper page
  3. Edwards, 1974, Alcoholism clinic in a military setting: a combined disulfiram and group therapy outpatient program, Military Medicine, 139, 206, 10.1093/milmed/139.3.206 · DOI
  4. 10.1097/00001504-198805000-00013 · DOI
  5. 10.1007/978-1-4613-3626-6_10 · DOI
  6. Vaillant, 1983, Natural History of Alcoholism.
  7. 10.1001/archpsyc.1973.01750360034004 · DOI
  8. 10.1111/j.1360-0443.1989.tb00760.x · DOI
  9. Searle, 1971, Linear Models.
  10. 10.1016/0005-7967(76)90028-0 · DOI
  11. 10.1002/1097-4679(198401)40:1<340::AID-JCLP2270400162>3.0.CO;2-J · DOI
  12. 10.1016/0005-7967(79)90107-4 · DOI
  13. 10.1080/01621459.1980.10477577 · DOI
  14. 10.1136/bmj.299.6697.471 · DOI
  15. Bourne, 1966, Treatment of skid-row alcoholics with disulfiram, Quarterly Journal of Studies on Alcohol, 27, 42, 10.15288/qjsa.1966.27.042 · DOI
  16. 10.1111/j.1530-0277.1986.tb05092.x · DOI
  17. 10.1016/0740-5472(86)90002-4 · DOI
  18. 10.1111/j.1360-0443.1983.tb05502.x · DOI · Paper page
  19. 10.1111/j.1360-0443.1988.tb03977.x · DOI
  20. 10.1016/S0140-6736(81)92413-2 · DOI

Cited by

Metadata

Authors
Chick, J., Gough, K., Falkowski, W., Kershaw, P., Hore, B., Mehta, B., Ritson, B., Ropner, R., & Torley, D.
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
1992-07
Volume
161
Issue
1
Pages
84-89
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.161.1.84
OpenAlex
W1977850625
Cited by
367
References
2
FWCI
11.08
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 9316 d)

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