Cited by 255Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

Drug therapy for alcohol dependence

Swift, Robert M.·1999·New England Journal of Medicine

Abstract

Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors.1 As defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders, it is characterized by increased tolerance of the effects of alcohol, impaired control over drinking, and continued drinking despite adverse consequences (Table 1).2 Alcohol dependence affects nearly 10 percent of the population and results in social problems, considerable morbidity and mortality, and high health care costs.3,4 Alcohol dependence is treated by medical, psychological, and social interventions that reduce or eliminate the desire to drink and the . . .

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Crossref · 10.1056/nejm199905133401907

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Authors
Swift, R. M.
Affiliations
Brown University (US)
Corresponding author
Swift, Robert M.
Venue
New England Journal of Medicine
Published
1999-05-13
Volume
340
Issue
19
Pages
1482-1490
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W1984819772
Cited by
255
References
97
Citations by year
2025: 3 · 2024: 7 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 11 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 5
FWCI
3.88
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords
alcoholism, pharmacotherapy, alcohol tolerance, impaired control, DSM-IV diagnostic criteria, health care costs
MeSH terms
Alcohol Deterrents, Ethanol, Alcoholism, Antidepressive Agents, Mental Disorders, Humans, Narcotic Antagonists, Receptors, Neurotransmitter, Dopamine Antagonists

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