Hippocampal volume and 2-year outcome in depression
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Summary: Although the hippocampus has been found to be smaller in people with depression, the clinical relevance of this is unclear. We investigated hippocampal volume (using high-resolution magnetic resonance imaging) and 2-year outcome in 57 patients with major depression. The left and right hippocampal volumes of patients with a depression relapse were significantly smaller than those of healthy controls. Our results support the hypothesis that the hippocampus is crucial in the outcome of depression.
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Smaller hippocampal and medial prefrontal cortex volumes are consistently linked to a more recurrent or relapsing course of major depressive disorder.
“they have been consistently associated with markers of a progressive course of MDD characterized by more recurrent episodes/relapses (3,19–25)”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [20]
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- Authors
- Kronmüller, K.-T., Pantel, J., Köhler, S., Victor, D., Giesel, F., Magnotta, V. A., Mundt, C., Essig, M., & Schröder, J.
- Affiliations
- Heidelberg University (DE)
- Goethe University Frankfurt (DE)
- German Cancer Research Center (DE)
- University of Iowa (US)
- Corresponding author
- Kronmüller, Klaus-Thomas
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2008-06
- Volume
- 192
- Issue
- 6
- Pages
- 472-473
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2132393278
- Cited by
- 107
- References
- 8
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 8
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- hippocampal volume, major depressive disorder, depression relapse, long-term outcomes, hippocampal atrophy, neuroimaging biomarkers, hippocampal asymmetry
- MeSH terms
- Adolescent, Adult, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Recurrence, Sex Factors, Epidemiologic Studies
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