Cited by 107Treatment of Major DepressionStress Responses and CortisolNeural and Behavioral Psychology Studies

Hippocampal volume and 2-year outcome in depression

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Kronmüller, Klaus-Thomas, Pantel, Johannes, Köhler, Sebastian, Victor, Daniela, Giesel, Frederik, Magnotta, Vincent A., Mundt, Christoph, Essig, Marco +1 more·2008·British Journal of Psychiatry

Abstract

Summary: Although the hippocampus has been found to be smaller in people with depression, the clinical relevance of this is unclear. We investigated hippocampal volume (using high-resolution magnetic resonance imaging) and 2-year outcome in 57 patients with major depression. The left and right hippocampal volumes of patients with a depression relapse were significantly smaller than those of healthy controls. Our results support the hypothesis that the hippocampus is crucial in the outcome of depression.

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  1. [7]7. Pantel J, O'Leary DS, Cretsinger K. A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus 2000; 10: 752-8.

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Authors
Kronmüller, K.-T., Pantel, J., Köhler, S., Victor, D., Giesel, F., Magnotta, V. A., Mundt, C., Essig, M., & Schröder, J.
Affiliations
  • Heidelberg University (DE)
  • Goethe University Frankfurt (DE)
  • German Cancer Research Center (DE)
  • University of Iowa (US)
Corresponding author
Kronmüller, Klaus-Thomas
Venue
British Journal of Psychiatry
Published
2008-06
Volume
192
Issue
6
Pages
472-473
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2132393278
Cited by
107
References
8
Citations by year
2026: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 8
FWCI
9.11
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
hippocampal volume, major depressive disorder, depression relapse, long-term outcomes, hippocampal atrophy, neuroimaging biomarkers, hippocampal asymmetry
MeSH terms
Adolescent, Adult, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Recurrence, Sex Factors, Epidemiologic Studies

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