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Neuropathological correlates of late-life depression in older people
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Background: Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. Aims: To investigate for the first time in a population-representative sample of people with no dementia the association between depression observed during life and neurofibrillary tangles, diffuse and neuritic plaques, Lewy bodies, brain atrophy and cerebrovascular disease found in the brain at post-mortem. Method: Out of 456 donations to a population-based study, 153 brains were selected where donors had no dementia measured in life. Alzheimer and vascular pathology measures, Lewy bodies and neuronal loss were compared between those with ( n = 36) and without ( n = 117) depression ascertained using a fully structured diagnostic interview during life. Brain areas examined included frontal, parietal, temporal and occipital cortical areas as well as the entorhinal cortex, hippocampus and brain-stem monoaminergic nuclei. Results: Depression was significantly associated with the presence of subcortical Lewy bodies. No association was found between depression and cerebrovascular or Alzheimer pathology in cortical or subcortical areas, although depression was associated with neuronal loss in the hippocampus as well as in some of the subcortical structures investigated (nucleus basalis, substantia nigra, raphe nucleus). Conclusions: Late-life depression was associated with subcortical and hippocampal neuronal loss but not with cerebrovascular or Alzheimer pathology.
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“Neither lacunes nor microvascular ischemic lesions were related to occurrence of late-onset depression65,66.”
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Metadata
- Authors
- Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E.
- Affiliations
- King's College London (GB)
- University of Cambridge (GB)
- University of Sheffield (GB)
- Newcastle University (GB)
- MRC Biostatistics Unit (GB)
- Corresponding author
- Stewart, Robert
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2011-02
- Volume
- 198
- Issue
- 2
- Pages
- 109-114
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2157134875
- Cited by
- 182
- References
- 43
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 36 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 12 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 14
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- South London and Maudsley NHS Foundation Trust
- National Institute for Health and Care Research
- King's College London
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- geriatric depression, older adults, neuropathology, Lewy bodies, neurofibrillary tangles, Alzheimer's disease pathology, cerebrovascular disease, hippocampal neuronal loss, brain atrophy, postmortem brain, dementia risk, nucleus basalis of Meynert, substantia nigra, raphe nuclei
- MeSH terms
- Aged, Aging, Alzheimer Disease, Autopsy, Brain, Depression, Depressive Disorder, Female, United Kingdom, Humans, Male, Middle Aged, Prospective Studies, Lewy Bodies
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