No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression
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OBJECTIVE: Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer's disease pathology. METHOD: F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment. Hippocampal volumes were defined manually and normalized for total intracranial volume. Amyloid binding was quantified using the standardized uptake value ratio in one cortical composite volume of interest. The authors investigated group differences in hippocampal volume (both including and excluding amyloid-positive participants), group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake. RESULTS: A significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects. CONCLUSIONS: Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer's disease.
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A neuroimaging study found no differences in cortical Aβ uptake or in the proportion of amyloid-positive subjects between depressed older patients and healthy controls.
“A neuroimaging study found no differences in cortical Aβ uptake or in the proportion of amyloid-positive subjects between depressed older patients and healthy controls120.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [120]
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- Authors
- De Winter, F.-L., Emsell, L., Bouckaert, F., Claes, L., Jain, S., Farrar, G., Billiet, T., Evers, S., Van den Stock, J., Sienaert, P., Obbels, J., Sunaert, S., Adamczuk, K., Vandenberghe, R., Van Laere, K., & Vandenbulcke, M.
- Affiliations
- From the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard...
- Massachusetts General Hospital (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2017-03
- Volume
- 174
- Issue
- 3
- Pages
- 237-245
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2515590939
- Cited by
- 80
- References
- 39
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 16 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 5
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- geriatric depression, hippocampal volume, Alzheimer's disease pathology, amyloid PET, apolipoprotein E, prodromal Alzheimer's disease, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Aniline Compounds, Atrophy, Belgium, Cerebral Cortex, Depressive Disorder, Female, Fluorine Radioisotopes, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Reference Values, Statistics as Topic, Imaging, Three-Dimensional, Positron-Emission Tomography, Benzothiazoles, Prodromal Symptoms
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