Neurodevelopmental hypothesis of schizophrenia
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Summary: The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be fully appreciated. Recent research indicates genetic overlap between schizophrenia and syndromes in which psychopathology is manifest in childhood and that are often grouped together as ‘neurodevelopmental disorders' such as autism-spectrum disorders, intellectual disability and attention-deficit hyperactivity disorder. These findings challenge the aetiological basis of current diagnostic categories and, together with evidence for frequent comorbidity, suggest that we should view the functional psychoses as members of a group of related and overlapping syndromes that result in part from a combination of genetic and environmental effects on brain development and that are associated with specific and general impairments of cognitive function. This has important implications for future research and for the configuration of psychiatric services.
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The overlapping genetic predisposition by 16p11.2 CNVs to both SZ and more typical NDDs like ASD and ID appears to support a neurodevelopmental origin of SZ.
“The overlapping genetic predisposition by 16p11.2 CNVs to both SZ and more typical NDDs like ASD and ID appears to support a neurodevelopmental origin of SZ [46].”
From 16p11.2 Copy Number Variations and Neurodevelopmental Disorders (2020) · cites this paper as [46]
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- Authors
- Owen, M. J., O'Donovan, M. C., Thapar, A., & Craddock, N.
- Affiliations
- Cardiff University (GB)
- Corresponding author
- Owen, Michael J.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2011-03
- Volume
- 198
- Issue
- 3
- Pages
- 173-175
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC3764497
- OpenAlex
- W2046645276
- Cited by
- 500
- References
- 33
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 26 · 2023: 25 · 2022: 42 · 2021: 49 · 2020: 38 · 2019: 49 · 2018: 25 · 2017: 36 · 2016: 17 · 2015: 33 · 2014: 32 · 2013: 35 · 2012: 36
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (076113)
- Cardiff University
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, neurodevelopmental disorders, autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, genetic overlap, comorbidities, functional psychoses, brain development, cognitive impairment, disease classification, etiology, mental health services
- MeSH terms
- Adolescent, Adult, Brain, Humans, Male, Intellectual Disability, Schizophrenia, Syndrome, Comorbidity, Genetic Predisposition to Disease, Young Adult
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