Cited by 85Attention Deficit Hyperactivity DisorderSubstance Abuse Treatment and OutcomesChild and Adolescent Psychosocial and Emotional Development

Stimulant treatment for attention-deficit hyperactivity disorder and risk of developing substance use disorder

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Groenman, Annabeth P., Oosterlaan, Jaap, Rommelse, Nanda N. J., Franke, Barbara, Greven, Corina U., Hoekstra, Pieter J., Hartman, Catharina A., Luman, Marjolein +5 more·2013·British Journal of Psychiatry

Abstract

Background: Attention-deficit hyperactivity disorder (ADHD) is linked to increased risk for substance use disorders and nicotine dependence. Aims: To examine the effects of stimulant treatment on subsequent risk for substance use disorder and nicotine dependence in a prospective longitudinal ADHD case–control study. Method: At baseline we assessed ADHD, conduct disorder and oppositional defiant disorder. Substance use disorders, nicotine dependence and stimulant treatment were assessed retrospectively after a mean follow-up of 4.4 years, at a mean age of 16.4 years. Results: Stimulant treatment of ADHD was linked to a reduced risk for substance use disorders compared with no stimulant treatment, even after controlling for conduct disorder and oppositional defiant disorder (hazard ratio (HR) = 1.91, 95% Cl 1.10−3.36), but not to nicotine dependence (HR = 1.12, 95% Cl 0.45−2.96). Within the stimulant-treated group, a protective effect of age at first stimulant use on substance use disorder development was found, which diminished with age, and seemed to reverse around the age of 18. Conclusions: Stimulant treatment appears to lower the risk of developing substance use disorders and does not have an impact on the development of nicotine dependence in adolescents with ADHD.

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  1. [17]17. Wilens TE, Adamson J, Monuteaux MC, Faraone SV, Schillinger M, Westerberg D, et al. Effect of prior stimulant treatment for attention- deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents. Arch Pediatr Adolesc Med 2008; 162: 916-21.

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Authors
Groenman, A. P., Oosterlaan, J., Rommelse, N. N. J., Franke, B., Greven, C. U., Hoekstra, P. J., Hartman, C. A., Luman, M., Roeyers, H., Oades, R. D., Sergeant, J. A., Buitelaar∗, J. K., & Faraone∗, S. V.
Affiliations
  • Vrije Universiteit Amsterdam (NL)
  • Radboud University Nijmegen (NL)
  • University of London (GB)
  • University Medical Center Groningen (NL)
  • Ghent University (BE)
  • University of Duisburg-Essen (DE)
Corresponding author
Groenman, Annabeth P.
Venue
British Journal of Psychiatry
Published
2013-08
Volume
203
Issue
2
Pages
112-119
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2122377852
Cited by
85
References
37
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 2
FWCI
7.32
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • VU Research Portal (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
  • Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • DuEPublico (University of Duisburg-Essen) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • Pfizer
  • Syracuse University
  • State University of New York
  • ZonMw (60-60600-97-193, 60600)
  • Shire
  • Servier
  • National Institutes of Health
  • State University of New York Upstate Medical University
  • Cilag
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
attention deficit hyperactivity disorder, stimulant medication, substance use disorders, nicotine dependence, adolescents, conduct disorder, oppositional defiant disorder, long-term outcomes
MeSH terms
Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Prospective Studies, Risk, Tobacco Use Disorder, Case-Control Studies, Conduct Disorder, Attention Deficit and Disruptive Behavior Disorders, Substance-Related Disorders

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