Stimulant treatment for attention-deficit hyperactivity disorder and risk of developing substance use disorder
Open accessAbstract
Background: Attention-deficit hyperactivity disorder (ADHD) is linked to increased risk for substance use disorders and nicotine dependence. Aims: To examine the effects of stimulant treatment on subsequent risk for substance use disorder and nicotine dependence in a prospective longitudinal ADHD case–control study. Method: At baseline we assessed ADHD, conduct disorder and oppositional defiant disorder. Substance use disorders, nicotine dependence and stimulant treatment were assessed retrospectively after a mean follow-up of 4.4 years, at a mean age of 16.4 years. Results: Stimulant treatment of ADHD was linked to a reduced risk for substance use disorders compared with no stimulant treatment, even after controlling for conduct disorder and oppositional defiant disorder (hazard ratio (HR) = 1.91, 95% Cl 1.10−3.36), but not to nicotine dependence (HR = 1.12, 95% Cl 0.45−2.96). Within the stimulant-treated group, a protective effect of age at first stimulant use on substance use disorder development was found, which diminished with age, and seemed to reverse around the age of 18. Conclusions: Stimulant treatment appears to lower the risk of developing substance use disorders and does not have an impact on the development of nicotine dependence in adolescents with ADHD.
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More recent studies report that medication treatment is linked to lower substance-related risk.
“In fact, several more recent studies have found that medication treatment is associated with decreased substance-related risk (18–20).”
From ADHD Medication and Substance-Related Problems (2017) · cites this paper as [18]
Experimental — accuracy not yet measuredStimulant use in childhood has neutral or protective effects on subsequent drug and alcohol use disorders.
“neutral or protective effects on sub sequent drug and alcohol use disorders 172-175 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [174]
In a prospective follow-up study by Groenman et al. (2013), stimulant treatment of childhood ADHD was associated with a lower risk of later SUD, but not of nicotine dependence, even after controlling for comorbid CD (HR = 1.91).
“In a prospective follow-up study by Groenman et al. (2013), stimulant treatment of childhood ADHD was associated with a lower risk of later SUD, but not of nicotine dependence, even after controlling for comorbid CD (HR = 1.91) [57].”
From Treatment of Adolescents with Concurrent Substance Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Systematic Review (2021) · cites this paper as [57]
Stimulant treatment of ADHD may reduce the risk of developing SUD.
“Stimulant treatment of ADHD may also reduce the risk of developing SUD”
From Gender Differences in Associations Between Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder. (2016) · cites this paper as [52]
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- Authors
- Groenman, A. P., Oosterlaan, J., Rommelse, N. N. J., Franke, B., Greven, C. U., Hoekstra, P. J., Hartman, C. A., Luman, M., Roeyers, H., Oades, R. D., Sergeant, J. A., Buitelaar∗, J. K., & Faraone∗, S. V.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Radboud University Nijmegen (NL)
- University of London (GB)
- University Medical Center Groningen (NL)
- Ghent University (BE)
- University of Duisburg-Essen (DE)
- Corresponding author
- Groenman, Annabeth P.
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-08
- Volume
- 203
- Issue
- 2
- Pages
- 112-119
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2122377852
- Semantic Scholar
- 4cad71b69987a21647f3aaf96c7a2d7dfbd1c67f
- Cited by
- 85
- References
- 37
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 2
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- VU Research Portal (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DuEPublico (University of Duisburg-Essen) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Syracuse University
- State University of New York
- ZonMw (60-60600-97-193, 60600)
- Shire
- Servier
- National Institutes of Health
- State University of New York Upstate Medical University
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- attention deficit hyperactivity disorder, stimulant medication, substance use disorders, nicotine dependence, adolescents, conduct disorder, oppositional defiant disorder, long-term outcomes
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Prospective Studies, Risk, Tobacco Use Disorder, Case-Control Studies, Conduct Disorder, Attention Deficit and Disruptive Behavior Disorders, Substance-Related Disorders
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